A5087012335- Cellular transport and secretion
- Pancreatic function and diabetes
- Inflammatory Biomarkers in Disease Prognosis
- Lipid metabolism and biosynthesis
- Hepatitis B Virus Studies
- Drug Transport and Resistance Mechanisms
- Platelet Disorders and Treatments
- Hepatitis C virus research
- Calcium signaling and nucleotide metabolism
- Cannabis and Cannabinoid Research
- Lipid Membrane Structure and Behavior
- Antiplatelet Therapy and Cardiovascular Diseases
- Endoplasmic Reticulum Stress and Disease
University of Graz
2024
Medical University of Graz
2019-2021
Abstract Bis(monoacylglycero)phosphate (BMP) is a major phospholipid constituent of intralumenal membranes in late endosomes/lysosomes, where it regulates the degradation and sorting lipid cargo. Recent observations suggest that Batten disease - associated protein CLN5 functions as lysosomal BMP synthase. Here, we show transacylation reactions catalyzed by cytosolic secreted enzymes enhance synthesis independently CLN5. The transacylases identified this study are capable acylating precursor...
Bis(monoacylglycero)phosphate (BMP) is a major phospholipid constituent of intralumenal membranes in late endosomes/lysosomes, where it regulates the degradation and sorting lipid cargo. Recent observations suggest that Batten disease-associated protein CLN5 functions as lysosomal BMP synthase. Here, we show transacylation reactions catalyzed by cytosolic secreted enzymes enhance synthesis independently CLN5. The transacylases identified this study are capable acylating precursor...