About
Contact & Profiles
A5093736046
Research Areas
- RNA Interference and Gene Delivery
- Virus-based gene therapy research
- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- Viral gastroenteritis research and epidemiology
Universidade Federal de Minas Gerais
2024
Abstract A safe and effective vaccine with long-term protection against SARS-CoV-2 variants of concern (VOCs) is a global health priority. Here, we develop lipid nanoparticles (LNPs) to provide delivery plasmid DNA (pDNA) show VOCs in female small animal models. Using library LNPs encapsulating unique barcoded (b-DNA), screen for b-DNA after intramuscular administration. The top-performing are further tested their capacity pDNA uptake antigen-presenting cells vitro. lead LNP used encapsulate...
10.1038/s41467-024-44830-1
article
EN
cc-by
Nature Communications
2024-01-18
10.1016/j.ijpharm.2024.124696
article
EN
International Journal of Pharmaceutics
2024-09-10
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