A5021308798- Immunotherapy and Immune Responses
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Wound Healing and Treatments
- SARS-CoV-2 and COVID-19 Research
- Burn Injury Management and Outcomes
- Cancer, Stress, Anesthesia, and Immune Response
- RNA Interference and Gene Delivery
- Hematopoietic Stem Cell Transplantation
- Pluripotent Stem Cells Research
- Immune Cell Function and Interaction
- Virology and Viral Diseases
- Sodium Intake and Health
- CAR-T cell therapy research
- Bone and Joint Diseases
- Blood Pressure and Hypertension Studies
- Intestinal and Peritoneal Adhesions
- Fungal Infections and Studies
- Immune cells in cancer
- Advancements in Transdermal Drug Delivery
- Retinoids in leukemia and cellular processes
- IL-33, ST2, and ILC Pathways
- Mosquito-borne diseases and control
- Reproductive System and Pregnancy
- Vagus Nerve Stimulation Research
Universidade Federal de Minas Gerais
2018-2025
Abstract A safe and effective vaccine with long-term protection against SARS-CoV-2 variants of concern (VOCs) is a global health priority. Here, we develop lipid nanoparticles (LNPs) to provide delivery plasmid DNA (pDNA) show VOCs in female small animal models. Using library LNPs encapsulating unique barcoded (b-DNA), screen for b-DNA after intramuscular administration. The top-performing are further tested their capacity pDNA uptake antigen-presenting cells vitro. lead LNP used encapsulate...
The tumour mass is composed not only of heterogeneous neoplastic cells, but also a variety other components that may affect cancer cells behaviour. lack detailed knowledge about all the constituents microenvironment restricts design effective treatments. Nerves have been reported to contribute growth and maintenance numerous tissues. effects sensory innervations on remain unclear. Here, by using state-of-the-art techniques, including Cre/loxP technologies, confocal microscopy, in...
Wound healing is a complex dynamic physiological process in response to cutaneous destructive stimuli that aims restore the cutaneous' barrier role. Deciphering underlying mechanistic details contribute wound will create novel therapeutic strategies for skin repair. Recently, by using state-of-the-art technologies, it was revealed microbiota interact with immune cells. Strikingly, commensal Staphylococcus epidermidis-induced CD8+ T cells induce re-epithelization of after injury, accelerating...
Abstract Sensory neurons have recently emerged as components of the tumor microenvironment. Nevertheless, whether sensory neuronal activity is important for progression remains unknown. Here we used Designer Receptors Exclusively Activated by a Drug (DREADD) technology to inhibit or activate neurons’ firing within melanoma tumor. Melanoma growth and angiogenesis were accelerated following inhibition reduced overstimulation these neurons. neuron-specific overactivation also induced boost in...
Dermal wound healing is the process of repairing and remodeling skin following injury. Delayed or aberrant cutaneous poses a challenge for health care system. The lack detailed understanding cellular molecular mechanisms involved in this hampers development effective targeted treatments. In recent study, Parfejevs et al.-using state-of-the-art technologies, including vivo sophisticated Cre/loxP techniques combination with mouse model excisional wounding-reveal that Schwann cells induce adult...
Joint pain is a distressing symptom experienced by arthritic patients and it frequently persistent even after treatments that reduce signs of local inflammation. Continuous production algogenic factors activate/sensitize nociceptors in the joint structures contribute to pain, challenging difficult condition treat. TNF crucial cytokine for pathogenesis several rheumatic diseases its inhibition mainstay treatment controlling symptoms, including pain. Here, we sought investigate inflammatory...
Abstract Introduction: Chimeric Antigen Receptor (CAR) T cells represent a breakthrough in cancer immunotherapy. However, current methods for engineering to express CARs are expensive and typically rely on viral vectors, which integrative have been linked severe adverse effects resulting from the continuous expression of CARs. In contrast, non-viral particularly lipid nanoparticles (LNPs), emerged as promising alternative generating CAR with transient expression. this study, we developed...
CXCL12 is a key chemokine implicated in neuroinflammation, particularly during Zika virus (ZIKV) infection. Specifically, upregulated circulating cells of ZIKV infected patients. Here, we developed lipid nanoparticle (LNP) to deliver siRNA vivo assess the impact silencing context The biodistribution LNP was assessed after intravenous injection using fluorescently tagged siRNA. Next, investigated ability silence and resulting effects murine model encapsulating significantly inhibited levels...