A5031161997- Neuroinflammation and Neurodegeneration Mechanisms
- Renin-Angiotensin System Studies
- Trypanosoma species research and implications
- Traumatic Brain Injury and Neurovascular Disturbances
- Long-Term Effects of COVID-19
- Tryptophan and brain disorders
- Muscle Physiology and Disorders
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Liver Disease and Transplantation
- Mosquito-borne diseases and control
- Liver Disease Diagnosis and Treatment
- Nerve injury and regeneration
- Research on Leishmaniasis Studies
- Genetic Neurodegenerative Diseases
- Healthcare Regulation
- S100 Proteins and Annexins
- Healthcare during COVID-19 Pandemic
- Coffee research and impacts
- Machine Learning in Healthcare
- Infectious Encephalopathies and Encephalitis
- Drug-Induced Hepatotoxicity and Protection
- Health, Environment, Cognitive Aging
- COVID-19 and Mental Health
- Physical Education and Gymnastics
Universidade Federal de Minas Gerais
2019-2025
The University of Texas Health Science Center at San Antonio
2025
Universidade de Ribeirão Preto
2019
Depression and anxiety have been reported as the major neuropsychiatric consequences following stroke. Minocycline, a neuroprotective drug has minimized depressive symptoms in patients with disorders anxiety-like symptoms. In addition, minocycline demonstrated efficacy seemed promising agent acute stroke patients. The present studied evaluated effects of treatment on depression behaviors, brain damage expression inflammatory mediators after transient global cerebral ischemia C57BL/6 mice....
The global impact of the COVID-19 pandemic has been unprecedented, and presently, world is facing a new challenge known as Post-COVID syndrome (PCS). Current estimates suggest that more than 65 million people are grappling with PCS, encompassing several manifestations, including pulmonary, musculoskeletal, metabolic, neuropsychiatric sequelae (cognitive behavioral). mechanisms underlying PCS remain unclear. present study aimed to: (i) comprehensively characterize acute effects pulmonary...
Huntington's disease (HD) is a neurodegenerative caused by CAG repeat expansion in the gene encoding huntingtin protein (HTT). This leads to formation of mutant (mHTT) that expressed many body tissue cells. The mHTT interacts with several molecular pathways within different cell types, affecting regulation immune system It still very limited understanding changes peripheral tissues HD. Herein, we investigated levels inflammatory and regulatory cytokines organs (i.e. kidney, heart, liver...
Neuroinflammation seems to be involved in the pathophysiology of Huntington’s Disease (HD), but its specific role on different stages disease, especially later stages, remains understood. Here in, we investigated concentrations cytokines, chemokines and neurotrophic factors striatum frontal cortex 24-month-old BACHD mice, a murine model that displays several behavioral pathological features human HD. Our results revealed increased chemokine MCP-1 neurotrophin NGF mice alongside reduction...
CXCL12 is a key chemokine implicated in neuroinflammation, particularly during Zika virus (ZIKV) infection. Specifically, upregulated circulating cells of ZIKV infected patients. Here, we developed lipid nanoparticle (LNP) to deliver siRNA vivo assess the impact silencing context The biodistribution LNP was assessed after intravenous injection using fluorescently tagged siRNA. Next, investigated ability silence and resulting effects murine model encapsulating significantly inhibited levels...
Hepatic encephalopathy (HE) is a neuropsychiatric syndrome that involves cognitive and motor dysfunctions due to hepatic failure. The clinical experimental studies suggest the angiotensin (Ang) converting enzyme (ACE), Ang II, type 1 receptor (AT1R), which compose classical pathway of renin-angiotensin system (RAS), exacerbate neuroinflammation in different neurologic diseases. Conversely, Ang-(1-7), ACE2, Mas receptor, integrate alternative RAS axis, have been shown as promising therapeutic...
Chagas disease (CD) is an important cause of cardiomyopathy in South America. The pathophysiology CD still a matter debate. Renin Angiotensin System (RAS) components are clearly involved cardiovascular diseases. RAS molecules interact with nitric oxide (NO) pathway blood vessel and heart tissue. Thus, the aim this study to investigate possible changes during infection Y strain T. cruzi response acute administration inhibitor enzyme NO synthase, l-NAME. Male Holtzman rats were inoculated...
Chagas' disease (CD) is a zoonosis caused by the protozoan Trypanosoma cruzi. Besides being an important cause of cardiomyopathy, central nervous system (CNS) manifestations have also been reported in CD. Renin-Angiotensin System (RAS) plays pathophysiological role several brain disorders such as cerebrovascular and neurodegenerative diseases. A link between RAS nitric oxide (NO) pathways has described CNS. For instance, Angiotensin-(1-7) increases NO expression brain, which may, turn, help...
Objetivo: estudo qualitativo com o objetivo de descrever impacto da descoberta doença coronariana no cotidiano das mulheres climatéricas.