A5008093274- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- Polyomavirus and related diseases
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Mesenchymal stem cell research
- Blood groups and transfusion
- Immunotherapy and Immune Responses
- Acute Myeloid Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Acute Lymphoblastic Leukemia research
- Complement system in diseases
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Neutropenia and Cancer Infections
- Chronic Lymphocytic Leukemia Research
- Mycobacterium research and diagnosis
- Hepatitis B Virus Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Transplantation: Methods and Outcomes
- Inflammasome and immune disorders
- Vascular Malformations and Hemangiomas
- T-cell and Retrovirus Studies
- Blood transfusion and management
Hospital Universitario Severo Ochoa
2023-2024
Columbia University
2024
National Heart Lung and Blood Institute
2007-2017
National Institutes of Health
2005-2017
Hospital Universitario Río Hortega
2012
National Cancer Institute
2009
University of Illinois Chicago
2003
Hospital Clínic de Barcelona
1997
To address disproportionately high rates of diabetes morbidity and mortality in some Chicago's medically underserved minority neighborhoods, a group community residents, medical social service providers, local university founded the Chicago Southeast Diabetes Community Action Coalition, Centers for Disease Control Prevention REACH 2010 Initiative.A communitybased participatory action research model guided coalition activities from conceptualization through implementation.Capacity building...
Abstract Plerixafor (Mozobil) is a CXCR4 antagonist that rapidly mobilizes CD34+ cells into circulation. Recently, plerixafor has been used as single agent to mobilize peripheral blood stem for allogeneic hematopoietic cell transplantation. Although G-CSF mobilization known alter the phenotype and cytokine polarization of transplanted T cells, effects on have not well characterized. In this study, we show alterations in gene expression profiles characteristic do occur after with plerixafor....
Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by intravascular hemolysis, venous thrombosis, and bone marrow failure. Seventeen patients with debilitating PNH, including 8 who were HLA-alloimmunized, underwent a reduced-intensity allogeneic hematopoietic cell transplantation (HCT). All received cyclophosphamide/fludarabine +/− antithymocyte globulin followed granulocyte colony-stimulating factor–mobilized HCT from an HLA-matched relative. Glycosylphosphatidylinositol-negative...
Severe aplastic anemia (SAA) is a rare disorder leading to bone marrow failure, which if left untreated, invariably fatal. Conventional therapies with immunosuppressive therapy or allogeneic hematopoietic stem cell transplantation (HSCT) are highly effective. HSCT can offer greater outcome in younger patients who have an available HLA match-related donor. Recent studies showing the addition of antithymocyte globulin (ATG) conditioning regimen improves engraftment and reduces risk...
Abstract Seed traits, such as seed color and size, directly impact quality, affecting the marketability value of dry peas [1]. Assessing quality is integral to a plant breeding programs ensure optimal standards. This research introduced phenotyping tool assess traits specifically tailored for pulse crops, which integrates image processing with cutting-edge deep learning models. The proposed method designed automation, seamlessly sequence images while minimizing human intervention. pipeline...
We evaluated the survival, mortality and colony growth over time after worker emergence in colonies of Atta laevigata (Fr. Smith) ants young pine tree plantations Pinus caribaea (Mor) located Estado Monagas, Venezuela. One hundred forty-four were inspected during a 41-month period. Colony one month was 45%. A small peak evidenced when 24 months old, coinciding with dry season. About 23% marked survived more than 3 years. During first two years, faster next as measured by total number nest...
Summary Allogeneic haematopoietic stem cell transplantation is curative for severe aplastic anaemia ( SAA ) unresponsive to immunosuppressive therapy. To reduce chronic graft‐ versus ‐host disease GVHD ), which occurs more frequently after peripheral blood PBSC compared bone‐marrow BMT and prevent graft rejection, we developed a novel partial T‐cell depleted transplant that infuses high numbers of granulocyte colony‐stimulating factor‐mobilized CD 34 + selected s combined with ‐equivalent...
The risk of graft-rejection after allogeneic hematopoietic cell transplantation using conventional cyclophosphamide-based conditioning is increased in patients with bone marrow failure syndromes (BMFS) who are heavily transfused and often HLA-alloimmunized. Fifty-six BMFS underwent fludarabine-based reduced-intensity peripheral blood progenitor (PBPC) at a single institution. regimen consisted intravenous cyclophosphamide, fludarabine, equine antithymocyte globulin. Graft-versus-host disease...
Bronchiolitis Obliterans Syndrome (BOS) is a late pulmonary complication of both lung and HSCT resulting in obstructive disease. For the latter, BOS thought to be manifestation chronic graft versus host disease (cGVHD). The mainstay therapy systemic immunosuppression, which increases risk infection reduces tumor effects. We investigated whether targeted, local delivery inhaled cyclosporine could improve or stabilize function patients. transplant recipients with were eligible if they met...
<h3>Background:</h3> Autoinflammatory syndromes (AIS) are a group of inherited diseases characterized by increased systemic inflammation caused disorders in the innate immune system. They include both monogenic Mendelian and more complex polygenic entities, which have mutations genes involved control various inflammatory pathways present with periodic or persistent clinical pictures. pediatric onset diagnosis, although there is an increasing number reported cases late adulthood. The...
O ciclo menstrual é um processo fisiológico complexo caracterizado por diversas variações hormonais. Os anticoncepcionais combinados orais (ACOs) interferem nesse através de hormônios exógenos, causam modificações no eixo e, consequentemente, aliviando sintomas como menorragia e dismenorreia. Cerca 151 milhões mulheres em idade fértil usam ACOs. Todavia esses medicamentos também estão associados a efeitos metabólicos indesejáveis. Estudos mostram que o uso ACOs pode influenciar desempenho...
<h3>Background</h3> Autoinflammatory syndromes encompass a group of diseases caused by dysregulation the innate immune system that classically present with periodic fevers and usually debut in childhood. <h3>Objectives</h3> An unusual case an autoinflammatory syndrome adult onset is presented. <h3>Methods:</h3> <h3>Results</h3> This 57-year-old woman, ex-smoker, ex-alcoholic, no other personal history interest. She was referred to internal medicine 2017 for weight loss 10-15 kg two months,...