A5028716816- Inflammatory mediators and NSAID effects
- Renal Transplantation Outcomes and Treatments
- Veterinary Equine Medical Research
- Pain Mechanisms and Treatments
- Osteoarthritis Treatment and Mechanisms
- Neuropeptides and Animal Physiology
- Pharmacological Effects and Assays
- Veterinary Orthopedics and Neurology
- Identification and Quantification in Food
- Total Knee Arthroplasty Outcomes
- Organ Donation and Transplantation
- Neurological Complications and Syndromes
- Shoulder Injury and Treatment
- Organ Transplantation Techniques and Outcomes
- Orthopaedic implants and arthroplasty
- Plant Toxicity and Pharmacological Properties
- Hernia repair and management
- Veterinary Medicine and Surgery
- Transplantation: Methods and Outcomes
- Analytical Methods in Pharmaceuticals
- Rheumatoid Arthritis Research and Therapies
- Veterinary Pharmacology and Anesthesia
- Listeria monocytogenes in Food Safety
- Healthcare and Venom Research
- Urinary Bladder and Prostate Research
Sharp Grossmont Hospital
2024
Therapeutics Clinical Research
2019-2022
Genesis Foundation
2021
Centrexion Therapeutics (United States)
2017-2020
Meridian Clinical Research
2014
Great Western Hospital
2011
QED Labs
2009-2011
Iowa State University
2008
Merck & Co., Inc., Rahway, NJ, USA (United States)
1998-2004
Anatolia College
2004
To assess the efficacy and safety of high-purity synthetic trans-capsaicin (CNTX-4975) in patients with chronic moderate-to-severe osteoarthritis (OA)-associated knee pain.In this phase II multicenter double-blind study, ages 45-80 years who had stable OA were randomized a 2:1:2 ratio to receive single intraarticular injection placebo, CNTX-4975 0.5 mg, or 1.0 mg. The primary end point was area under curve (AUC) for change from baseline daily Western Ontario McMaster Universities...
Abstract Objective —To compare efficacy and safety of paste formulations firocoxib phenylbutazone in horses with naturally occurring osteoarthritis. Design —Randomized controlled clinical trial. Animals —253 client-owned Procedures —Horses were treated (0.1 mg/kg [0.045 mg/lb], PO, q 24 h) or (4.4 [2 for 14 days. Physical examinations lameness evaluations performed prior to treatment after 7 Clinical improvement was defined as a reduction at least 1 grade combined 3 points scores pain during...
Objective To test the long-term effect of enalapril maleate treatment on progression clinical signs heart disease in dogs with moderate or severe naturally acquired failure associated chronic degenerative mitral valvular (mitral regurgitation [MR]) dilated cardiomyopathy (DCM). Design Prospective multicenter study. Animals 110 enrolled at 15 locations United States. Procedure All this study were maintained their randomly allocated regimen until death, (deterioration condition requiring...
Abstract Objective —To determine cyclooxygenase-2 (COX-2) selectivity, pharmacokinetic properties, and in vivo efficacy of ML-1,785,713 dogs. Animals —21 healthy male female mixed-breed dogs 24 Beagles. Procedure —Selectivity for inhibiting COX-2 was determined by comparing the potency cyclooxygenase-1 (COX-1) with that canine blood. Pharmacokinetic properties were after IV (2 mg/kg) oral (8 administration In evaluated urate crystal-induced synovitis. Prophylactic administering two hours...
The primary objective of this study was to determine the pharmacokinetic profile firocoxib, a novel second generation coxib, in horses. Horses were administered either single oral or intravenous dose firocoxib at 0.1 mg/kg two‐period crossover with 12 animals. dosage based on previously determined pharmacodynamic parameters. Oral well absorbed an average bioavailability (absolute) 79% and C max 75 ng/mL 3.9 h. elimination half‐life 30 Following administration 210 34 area under curve [ AUC...
A double‐blind, randomised, controlled, multicentre field study was conducted to compare the safety and efficacy of firocoxib chewable tablets carprofen in 218 dogs with osteoarthritis. Firocoxib is a non‐steroidal anti‐inflammatory drug more than 350‐fold selectivity for inducible isoform enzyme cyclo‐oxygenase‐2. The efficacy, tolerance ease administration (5 mg/kg/day) (4 were assessed by owners attending veterinarians during 30 days treatment. terms dogs' overall scores at end treatment,...
Background Cisplatin combined with a nonselective cyclooxygenase (cox) inhibitor has potent antitumor activity against transitional cell carcinoma ( TCC ) in dogs, but this treatment is limited by renal toxicosis. Cox‐2 expressed , only sites within the kidney. A cox‐2 could enhance of cisplatin potentially fewer adverse effects on Hypothesis Cisplatin/cox‐2 will have greater no more toxicosis than alone dogs . Animals Forty‐four naturally occurring urinary bladder Methods Dogs were...
Abstract Objective —To determine pharmacokinetic parameters and variables, firocoxib concentrations in urine plasma, urine-to-plasma ratios, the depletion profile of to evaluate whether behavior was governed by linear processes after multiple doses were administered IV orally. Animals —6 healthy female horses (5 Paint 1 Quarter Horse) experiment 12 male 2. Procedures —In 1, 6 orally paste once daily for consecutive days, plasma samples obtained analyzed. In a second experiment, received...
Lameness is a highly prevalent condition in horses and the principal cause of removal from athletic activity. In clinical studies to evaluate nonsteroidal anti-inflammatory drug therapies, force plates are commonly used assess improvement lameness objectively.To use plate determine optimal dose new COX-2 inhibitor (firocoxib) that will reduce lameness, when administered orally once daily.Sixty-four exhibited chronic presumed due osteoarthritis, including navicular disease, at least one...
Knee osteoarthritis (KOA) is a prevalent condition characterized by the progressive deterioration of entire joint and has emerged as prominent contributor to disability on global scale. The nature disease its impact function significantly limit mobility daily activities, highlighting substantial influence patients' overall well-being. Stromal vascular fraction (SVF) heterogenous, autologous cell product, containing mesenchymal stem cells, derived from patient's subcutaneous adipose tissue...
Two studies were conducted under laboratory conditions with 16 dogs to investigate the analgesic effectiveness of a low dose ketoprofen in short-term sodium urate crystal-induced synovitis model arthritis. The effect treatment, defined as improvement peak vertical force weight bearing was evaluated first study at three levels. A single oral 0.25 mg/kg significantly better (P < 0.01) than control (0 mg), but doses 0.5 and 0.75 did not improve dogs' further. second investigated efficacy safety...
A 5-year-old Quarter Horse mare was examined because of a 6-month history quidding and nasal discharge that contained feed material. Physical examination revealed weight loss dorsal displacement the soft palate, caused by tissue mass located at aspect base tongue. Surgical resection successfully performed through an oral approach. The histopathologic diagnosis rhabdomyosarcoma.
Abstract The automated system for enumeration of total viable count (TVC) in foods, TEMPO® TVC, uses a dehydrated culture medium and an card containing 48 wells across 3 different dilutions the automatic determination most probable number (MPN). alternative method was compared multilaboratory collaborative study to AOAC Method 966.23 aerobic plate nondairy products Standard Methods Examination Dairy Products (SMEDP) Plate Count dairy products. Five food types, raw ground beef, chicken,...
Summary As more sophisticated research is performed to refine fracture fixation techniques for horses, it important that normal values the geometric properties of bones appendicular skeleton be determined and suitable controls available. We evaluated total bone width, cortical medullary canal/trabecular width measured from 2 radiographic projections equine long (humerus, radius, third metacarpal bone, femur, tibia, metatarsal bone) obtained a general population horses. Measurements were on...
SUMMARY We evaluated the single-cycle structural properties for axial compression, torsion, and 4-point bending with a central load applied to caudal or lateral surface of diaphyseal segment from normal adult equine humerus, radius, third metacarpal bone, femur, tibia, metatarsal bone. Stiffness values were determined load-deformation curves each bone test mode. Compressive stiffness ranged low 2,690 N/mm humerus high 5,670 femur. Torsional 558 N · m/rad 2,080 Nondestructive 3,540 radius...
The automated method for enumeration of Escherichia coli, TEMPO EC, in foods uses a dehydrated culture medium and card containing 48 wells across three different dilutions the automatic determination most probable number (MPN). alternative was compared multilaboratory collaborative study to AOAC Official Method 966.24. Six food types were artificially contaminated with E. coli: raw ground beef, bagged lettuce, cooked chicken, pasteurized crabmeat, frozen green beans, whole milk. All analyzed...