A5101926088- Synthetic Organic Chemistry Methods
- Viral gastroenteritis research and epidemiology
- Microbial Natural Products and Biosynthesis
- Irrigation Practices and Water Management
- Biological Activity of Diterpenoids and Biflavonoids
- SARS-CoV-2 and COVID-19 Research
- Marine Sponges and Natural Products
- Plant biochemistry and biosynthesis
- Plant Gene Expression Analysis
- Soil and Unsaturated Flow
- Phytochemical compounds biological activities
- Polymer-Based Agricultural Enhancements
- Plant Water Relations and Carbon Dynamics
- Natural product bioactivities and synthesis
- Plant-Microbe Interactions and Immunity
- Chemical synthesis and alkaloids
- Microplastics and Plastic Pollution
- Viral Infections and Immunology Research
- Water Quality Monitoring Technologies
- Cyclization and Aryne Chemistry
- Tree Root and Stability Studies
- Impact of AI and Big Data on Business and Society
- Urban Design and Spatial Analysis
- Educational Reforms and Innovations
- Marine Biology and Environmental Chemistry
Hebei Agricultural University
2025
Tsinghua University
2011-2024
Guangxi Medical University
2024
Beijing Advanced Sciences and Innovation Center
2022-2024
University of Manchester
2024
Beijing Forestry University
2021-2023
Zhejiang Ocean University
2022-2023
Zhejiang University
2022-2023
Shanghai Institute of Ceramics
2023
Chinese Academy of Sciences
2013-2023
The first total syntheses of taiwaniadducts B, C, and D have been accomplished. Two diterpenoid segments were prepared with high enantiopurity, both through Ir-catalyzed asymmetric polyene cyclization. A sterically demanding intermolecular Diels-Alder reaction promoted by Er(fod)3 assembled the scaffold B C. carbonyl-ene cyclization forged cage motif taiwaniadduct at a late stage, providing over 200 mg this compound.
Abstract The respiratory system, especially the lung, is key site of pathological injury induced by SARS-CoV-2 infection. Given low feasibility targeted delivery antibodies into lungs intravenous administration and short half-life period in intranasal or aerosolized immunization, mRNA encoding broadly neutralizing with lung-targeting capability can perfectly provide high-titer to prevent Here, we firstly identify a human monoclonal antibody, 8-9D, broad potency against variants....
A divergent approach was developed toward the total synthesis of taiwaniaquinoids. An advanced intermediate 5a with trans A/B ring junction concisely assembled by employing a Bi(OTf)3-catalyzed cationic cyclization and Wolff-type contraction as key steps. This common readily converted to racemic taiwaniaquinones F taiwaniaquinols B D, respectively.
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTTotal Synthesis of Shishijimicin AK. C. Nicolaou*, Zhaoyong Lu, Ruofan Li, James R. Woods, and Te-ik SohnView Author Information Department Chemistry, Rice University, 6100 Main Street, Houston, Texas 77005, United States*[email protected]Cite this: J. Am. Chem. Soc. 2015, 137, 27, 8716–8719Publication Date (Web):July 2, 2015Publication History Received29 May 2015Published online2 July inissue 15...
Shishijimicin A is a scarce marine natural product with highly potent cytotoxicities, making it potential payload or lead compound for designed antibody–drug conjugates. Herein, we describe an improved total synthesis of shishijimicin and the design, synthesis, biological evaluation series analogues. Equipped appropriate functionalities linker attachment, number these analogues exhibited extremely cytotoxicities intended purposes. The synthetic strategies tactics developed employed in...
Abstract As new variants of SARS-CoV-2 continue to emerge, it is important assess the cross-neutralizing capabilities antibodies naturally elicited during wild type infection. In present study, we evaluate activity nine anti-SARS-CoV-2 monoclonal (mAbs), previously isolated from convalescent donors infected with Wuhan-Hu-1 strain, against concern (VOC) Alpha, Beta, Gamma, Delta and Omicron. By testing an array mutated spike receptor binding domain (RBD) proteins, cell-expressed proteins...
Quantifying planting layouts during the seedling stage of mung beans (Vigna radiata L.) is crucial for assessing cultivation conditions and providing support precise management. Traditional information extraction methods are often hindered by engineering workloads, time consumption, labor costs. Applying deep-learning technologies reduces these burdens yields reliable results, enabling a visual analysis distribution. In this work, an unmanned aerial vehicle (UAV) was employed to capture...
The architecturally symmetrical and synthetically challenging marine natural products lomaiviticins A B present alluring synthetic targets due to their molecular complexity, potent antitumor properties, scarcity. Herein, we report the total synthesis of fully glycosylated monomeric unit lomaiviticin A, monolomaiviticin A. retrosynthetically derived strategy relied on an intramolecular palladium-catalyzed coupling reaction complete tetracyclic aglycon scaffold gold-promoted glycosylations...
Although shishijimicin A and its extreme potencies against an array of cancer cell lines have been known for more than a decade, assumed DNA-cleaving mechanism has not substantiated as yet. Herein we report studies that reveal binding scission double-stranded DNA by A. The results these support the proposed hypothesis strand scissions are caused 1,4-benzenoid diradicals formed Bergman cycloaromatization enediyne core upon activation thiols. In addition, supercoiled DNA-cleavage experiments...
Abstract Objectives This study investigated the characteristics of workplace violence (WPV) against Chinese healthcare staff and their casualties after severe physical (PV). Methods We scrutinized medical WPV incidents reported online analyzed information on timing, location, violence, criminal incentives, following PV in China from 2010 to 2020. Results WPVs were mostly committed by young middle-aged male family members patients, especially emergency department (49.1%), associated with...
To investigate the expression characteristics of long non-coding RNA (lncRNA) in colon adenocarcinoma (COAD) and its potential value predicting prognosis patient survival.We downloaded COAD-related sequencing (RNA-seq) data survival from The Cancer Genome Atlas (TCGA). were analyzed for lncRNA differences, subjected to Cox regression analysis rate, Kaplan-Meier (KM) curves plotted analyze role key genes related prognostic by pathway enrichment analysis.The 494 COAD clinical samples TCGA...
Sulfamethoxazole (SMX), is a ubiquitous antibiotic in the aquatic environment and received concerns on its health hazards, especially sub-lethal effects non-target organisms which were remained largely unknown. In present study, order to investigate SMX induced tissue damages reveal underlying mechanisms, marine mussels, Mytilus galloprovincialis challenged series (0.5, 50 500 μg/L) for six-days followed by six-day-recovery. Comprehensive histopathological alteration (including qualitative,...
Namenamicin is a rare natural product possessing potent cytotoxic properties that may prove useful as lead compound for payloads of antibody-drug conjugates (ADCs). Its scarcity, coupled with the uncertainty its full absolute configuration, elevates it to an attractive synthetic target. Herein we describe total synthesis two C7'-epimers namenamicin and assign complete structure, opening way further chemical biological studies toward discovery ADCs directed targeted cancer therapies.
A streamlined total synthesis of the naturally occurring antitumor agents trioxacarcins is described, along with its application to construction a series designed analogues these complex natural products. Biological evaluation synthesized compounds revealed number highly potent, and yet structurally simpler, that are effective against certain cancer cell lines, including drug-resistant line. novel one-step anthraquinones chloro from simple ketone precursors phenylselenyl chloride also...
Accurately predicting the evapotranspiration of orchard is great significance for improving water use efficiency and optimizing management orchard. Based on both mechanism storage pit irrigation Shuttleworth-Wallace dual-source model, an model SWp suitable trees was established in this study. The measured by thermal diffusion sap flow meter mic-lysimeter methods during 2018 were used to verify performance PM SW under conditions. results show that: (1) established, Nash coefficient 0.93; (2)...
Abstract Amur honeysuckle (Lonicera maackii) is a widely used medicinal plant of the Caprifoliaceae family that produces chlorogenic acid. Research on this mainly focuses its ornamental value and compounds, but reference genome sequence molecular resources for accelerated breeding are currently lacking. Herein, nanopore sequencing high-throughput chromosome conformation capture (Hi-C) allowed chromosome-level assembly L. maackii (2n = 18). A global view gene regulatory network involved in...
Our previous studies with shishijimicin A resulted in the total synthesis of this scarce marine natural product and a number its simpler analogues endowed picomolar potencies against certain cancer cell lines. Herein, we describe design, synthesis, biological evaluation four linker-drugs, anticipating construction antibody-drug conjugates (ADCs) as ultimate goal research program. Using common payload, assembly these linker-drugs utilized different linkers attachment points, providing...
Photo biodegradable film is an ideal degradable mulch with synergistic effect of photo-degradability and biodegradability. To examine the covering effects different films, maize was cultivated in field three kinds films (DF) mulching which had degradation cycles (DF No. 1, 2 3), common plastic no filming (open ground) as comparison. The rates degrees were examined, on soil temperature, moisture, yield relevant characteristics each treatment analyzed. results indicated that good...