A5102657905- Vestibular and auditory disorders
- Cancer-related molecular mechanisms research
- Ear Surgery and Otitis Media
- Hearing, Cochlea, Tinnitus, Genetics
- Otitis Media and Relapsing Polychondritis
- Sinusitis and nasal conditions
- Hippo pathway signaling and YAP/TAZ
Eye & ENT Hospital of Fudan University
2024-2025
State Key Laboratory of Medical Neurobiology
2024-2025
Fudan University
2024-2025
Background: Sensorineural hearing loss (SNHL) is a major contributor to impairment, yet effective therapeutic options remain elusive. Mendelian randomization (MR) has proven valuable for drug repurposing and identifying new targets. This study aims pinpoint novel treatment targets SNHL, exploring their pathophysiological roles potential adverse effects. Methods: research utilized the UKB-PPP database access cis-protein quantitative trait locus (cis-pQTL) data, with SNHL data sourced from...
Introduction Menière’s disease (MD) is a multifactorial characterised by recurring vertigo, tinnitus and fluctuating sensorineural hearing loss as typical clinical symptoms. For patients with MD poor response to non-invasive treatments, it recommended use intratympanic gentamicin treatment. The destruction of vestibular organs may cause residual symptoms, notably unsteadiness. However, most previous studies paid little attention this issue. Currently, rehabilitation treatment (VRT) has been...
Background: Sensorineural hearing loss (SNHL) is a multifactorial disorder with potential links to various physiological systems, including the cardiovascular system via blood lipid levels such as triglycerides (TG). This study investigates causal relationship between TG and SNHL using Mendelian randomization (MR), which offers method reduce confounding reverse causality by genetic variants instrumental variables. Methods: Utilizing publicly available genome-wide association (GWAS) data, we...