This study aimed to explore the pharmacological mechanism of Dangshen (Codonopsis pilosula) against hepatocellular carcinoma (HCC) based on network pharmacology and bioinformatics, verify anticancer effect luteolin, active ingredient Codonopsis pilosula, HCC cells.The effective compounds potential targets pilosula were established using Traditional Chinese Medicine Systems Pharmacology Database Analysis Platform (TCMSP) database. The genes related obtained through GeneCards interactive...

Background: Sensorineural hearing loss (SNHL) is a major contributor to impairment, yet effective therapeutic options remain elusive. Mendelian randomization (MR) has proven valuable for drug repurposing and identifying new targets. This study aims pinpoint novel treatment targets SNHL, exploring their pathophysiological roles potential adverse effects. Methods: research utilized the UKB-PPP database access cis-protein quantitative trait locus (cis-pQTL) data, with SNHL data sourced from...

Background: Sensorineural hearing loss (SNHL) is a multifactorial disorder with potential links to various physiological systems, including the cardiovascular system via blood lipid levels such as triglycerides (TG). This study investigates causal relationship between TG and SNHL using Mendelian randomization (MR), which offers method reduce confounding reverse causality by genetic variants instrumental variables. Methods: Utilizing publicly available genome-wide association (GWAS) data, we...

T-box transcription factor 15 (TBX15) is upregulated in a variety of tumors and has been reported to promote uncontrolled proliferation tumor cells induce avoid apoptosis, thus accelerating the malignant transformation tumors. However, prognostic value TBX15 glioma its relationship with immune infiltration remain unknown. In this study, we intended explore link examine expression pan-cancer using RNAseq data TPM format from TCGA GTEx. mRNA protein expressions adjacent normal tissue were...

Abstract Background Coronary atherosclerosis (CA) is the most common type of atherosclerosis. However, inherent pathogenesis and mechanisms CA are unclear, relationship with ferroptosis-related genes (FRGs) has not been reported. The purpose this study was to use bioinformatics techniques evaluate potential therapeutic targets for CA.Please provide given name author “Dingshun”.Please “Dingshun”. Methods First, GSE132651 dataset acquired from Gene Expression Omnibus database. Ontology...

Carcinoma with signet ring cell differentiation is uncommon in patients invasive breast cancer. Clinical evidence has suggested that the prognosis of this tumor usually poor if stage advanced. The case a 40-year-old female patient primary cancer right accompanied by bilateral neck, axillary, subclavian and mediastinal lymph node metastases, left metastasis presented current study. developed superior vena cava syndrome was restricted lifting upper limb when presenting at Third Affiliated...

Chronic rhinosinusitis (CRS) is a complex condition brought on for many reasons, and its prevalence rising gradually around the world. Xanthii Fructus (XF) has been used in treatment of CRS decades effective. The chemical pharmacological profiles XF, other hand, are still unknown need to be clarified. potential mechanisms XF were investigated using network pharmacology approach this study. OB DL charge screening bioactive components drug-likeness. TCMSP PubChem databases identify prospective...

The aim of this study was to explore the regulatory role epoxide hydrolase 3 (EPHX3) in head and neck squamous cell carcinoma (HNSCC) analyze its bioinformatic function, as well as, screen predict miRNAs that can regulate EPHX3 expression HNSCC. We examined profile prognostic potential TCGA GTEX databases performed functional enrichment analysis using string database. Subsequently, we analyzed on EPHX3, including analysis, correlation survival analysis. In addition, also used TIMER...

Safflower has long been used to treat coronary heart disease (CHD). However, the underlying mechanism remains unclear. The goal of this study was predict therapeutic effect safflower against CHD using a network pharmacology and explore pharmacological mechanisms. Firstly, we obtained relative compounds based on TCMSP database. PubChem databases were targets these active compounds. Then, built CHD-related by DisGeNET protein-protein interaction (PPI) graph overlapping genes after supplying...

<title>Abstract</title> OBJECTIVE The study was designed with the aim of excavating diagnostic biomarkers venous thromboembolism (VTE). METHODS GSE19151 and GSE48000 datasets were subjected into this study. pyroptosis-related genes (PRGs) sourced from literature^{<bold>1</bold>}. Differential expression analysis WGCNA applied to identify differential related Pyroptosis (DE-PRGs) in VTE. possible functions DE-PRGs defined by means enrichment analysis. pyroptosis VTE determined...

Abstract Purpose MYL2, a potential biomarker, is aberrantly expressed in variety of tumor tissues. The purpose this study was to determine the exact involvement MYL2 HNSC. Methods Massive bioinformatics analysiswere used assess mRNA and protein expression levels its functional role Next, prognostic effect on HNSC analyzed using TCGA GEPIA. Afterwards, immune microenvironment examined by infiltration monomolecular analysis. Finally, immunohistochemistry, western blot, RT-PCR, Plasmid...

Abstract The significance of MYL2 as a possible HNSC treatment gene is unknown, the purpose this study was to determine exact involvement in HNSC.The Tumor Immune Estimate Resource (TIMER), UALCAN, Cancer Genome Atlas (TCGA), and Gene Expression Omnibus (GEO) databases were used assess mRNA protein expression levels HNSC. Experimental tests, including immunohistochemistry, corroborate findings using tumor tissues normal controls. Next, prognostic effect on analyzed TCGA GEPIA. Understanding...

Cystatin E/M (CST6), a representative cysteine protease inhibitor, plays both tumor-promoting and tumor-suppressing functions is pursued as an epigenetically therapeutic target in special cancer types. However, comprehensive systematic analysis for CST6 pan-cancer level still lacking. In the present study, we explored expression pattern of multiple types across ∼10,000 samples from TCGA (The Cancer Genome Atlas) ∼8,000 MMDs (Merged Microarray-acquired Datasets). We found that dynamic...

Objective A prospective experiment was designed to explore all possible SNPs in the promoter region of fibrinogen B β (FGB) and reveal influence these on susceptibility pulmonary embolism. Methods In this 2-year randomized study, we had totally recruited 203 volunteers. 58 PE patients (58 out 145 VTE patients) 114 healthy people were taken as case control objects, respectively. FGB detected by gene sequencing. Results There 6 promoter, which β-1420G/A, β-993C/T, β-854G/A, β-455G/A, β-249C/T,...

Abstract Background: Safflower has long been used to treat coronary heart disease (CHD). However, the underlying mechanism remains unclear. The goal of this study was predict therapeutic effect safflower against CHD using a network pharmacology, and explore pharmacological mechanisms in vitro. Methods: Firstly, we obtained relative compounds based on TCMSP database. PubChem databases were targets these active compounds. Then built target database by DisGeNET protein-protein interaction (PPI)...

Abstract In this study, We comprehensively analyzed 20 genes from The Cancer Genome Atlas(TCGA) HNSCC database (YTHDF1, FTO, YTHDF2, YTHDF3, HNRNPA2B1, METTL14, METTL3, IGF2BP1, HNRNPC, IGF2BP2, RBMX, IGF2BP3, YTHDC1, YTHDC2, RBM15, RBM15B, VIRMA, ZC3H13, WTAP, ALKBH5) to predict whether there is an impact on the prognosis of patients with HNSCC. importance m6A regulators such as VIRMA in pathogenesis was emphasized. These findings will provide a therapeutic approach and new research...

Abstract T-box transcription factor 15 (TBX15) is upregulated in a variety of tumors and has been reported to promote uncontrolled proliferation tumor cells induce avoid apoptosis, thus accelerating the malignant transformation tumors. However, prognostic value TBX15 glioma its relationship with immune infiltration remain unknown. In this study, we intended explore link examine expression pan-cancer using RNAseq data TPM format from TCGA GTEx. mRNA protein expressions adjacent normal tissue...