A5075987950- Inflammasome and immune disorders
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Atrial Fibrillation Management and Outcomes
- Cancer, Lipids, and Metabolism
- Cardiac electrophysiology and arrhythmias
- Atherosclerosis and Cardiovascular Diseases
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- Sunflower and Safflower Cultivation
- Cardiac Arrhythmias and Treatments
- interferon and immune responses
- Glioma Diagnosis and Treatment
- Pressure Ulcer Prevention and Management
- Wound Healing and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Lipid metabolism and disorders
- Gout, Hyperuricemia, Uric Acid
- Lymphoma Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Gastrointestinal Tumor Research and Treatment
- Peroxisome Proliferator-Activated Receptors
- Burn Injury Management and Outcomes
Hainan Medical University
2022-2023
Huang Qi (HQ, Astragalus) and Hong Hua (HH, Safflower), two Chinese herbal remedies, are widely used to treat coronary heart disease (CHD). However, the underlying mechanisms of this herb pair remain unclear. The aim study was determine potential synergistic effects Astragalus-Safflower in treatment CHD.Network pharamcology performed identify core components, targets, key genes (ASHP) for CHD. Enrichment analysis overlapping genes. Ultrahigh-performance liquid chromatography coupled with...
T-box transcription factor 15 (TBX15) is upregulated in a variety of tumors and has been reported to promote uncontrolled proliferation tumor cells induce avoid apoptosis, thus accelerating the malignant transformation tumors. However, prognostic value TBX15 glioma its relationship with immune infiltration remain unknown. In this study, we intended explore link examine expression pan-cancer using RNAseq data TPM format from TCGA GTEx. mRNA protein expressions adjacent normal tissue were...
Abstract Background Coronary atherosclerosis (CA) is the most common type of atherosclerosis. However, inherent pathogenesis and mechanisms CA are unclear, relationship with ferroptosis-related genes (FRGs) has not been reported. The purpose this study was to use bioinformatics techniques evaluate potential therapeutic targets for CA.Please provide given name author “Dingshun”.Please “Dingshun”. Methods First, GSE132651 dataset acquired from Gene Expression Omnibus database. Ontology...
G protein-coupled receptor 124 (GPR124) regulates central nervous system angiogenesis and blood-brain barrier (BBB) integrity, its deficiency aggravates BBB breakdown hemorrhagic transformation in ischemic mice. However, excessive GPR124 expression promotes inflammation atherosclerotic In this study, we aimed to elucidate the role of hypoxia/ischemia-induced cerebrovascular endothelial cell injury.bEnd.3 cells were exposed oxygen-glucose deprivation (OGD), time-dependent changes mRNA protein...
Abstract Background Adipose stem cell‐derived exosomes (ADSC‐EXO) and botulinum toxin type A (BTX‐A) individually showed a therapeutic effect on skin wound repair. Aims This study investigated their synergistic promoting healing in vitro vivo the underlying molecular events. Methods ADSCs were isolated from Sprague–Dawley (SD) rats to obtain ADSC‐EXO by ultrafiltration ultracentrifugation confirmed using nanoparticle tracking analysis transmission electron microscopy. Human fibroblasts (HSF)...
Safflower has long been used to treat coronary heart disease (CHD). However, the underlying mechanism remains unclear. The goal of this study was predict therapeutic effect safflower against CHD using a network pharmacology and explore pharmacological mechanisms. Firstly, we obtained relative compounds based on TCMSP database. PubChem databases were targets these active compounds. Then, built CHD-related by DisGeNET protein-protein interaction (PPI) graph overlapping genes after supplying...
Abstract The significance of MYL2 as a possible HNSC treatment gene is unknown, the purpose this study was to determine exact involvement in HNSC.The Tumor Immune Estimate Resource (TIMER), UALCAN, Cancer Genome Atlas (TCGA), and Gene Expression Omnibus (GEO) databases were used assess mRNA protein expression levels HNSC. Experimental tests, including immunohistochemistry, corroborate findings using tumor tissues normal controls. Next, prognostic effect on analyzed TCGA GEPIA. Understanding...
Abstract Background Recent study has shown that the transient receptor potential vanilloid 2 (TRPV2) channel was exclusively upregulated in patients with atrial fibrillation (AF), and this overexpression might be detrimental for occurrence maintenance of AF. We aimed to characterize expression levels TRPV2 mRNA peripheral blood mononuclear cells (PBMCs) with/without early recurrence (ERAF) after radiofrequency catheter ablation (RFCA), find a reliable predictor ERAF. Methods 65 AF, who...
Abstract Background: Safflower has long been used to treat coronary heart disease (CHD). However, the underlying mechanism remains unclear. The goal of this study was predict therapeutic effect safflower against CHD using a network pharmacology, and explore pharmacological mechanisms in vitro. Methods: Firstly, we obtained relative compounds based on TCMSP database. PubChem databases were targets these active compounds. Then built target database by DisGeNET protein-protein interaction (PPI)...
Abstract Background:: Recent study has shown that the transient receptor potential vanilloid 2 (TRPV2) channel was exclusively upregulated in patients with atrial fibrillation (AF), and this overexpression might be detrimental for occurrence maintenance of AF. We aimed to characterize expression levels TRPV2 mRNA peripheral blood mononuclear cells (PBMCs) with/without early recurrence (ERAF) after radiofrequency catheter ablation (RFCA), find a reliable predictor ERAF. Methods: 65 AF, who...
Abstract T-box transcription factor 15 (TBX15) is upregulated in a variety of tumors and has been reported to promote uncontrolled proliferation tumor cells induce avoid apoptosis, thus accelerating the malignant transformation tumors. However, prognostic value TBX15 glioma its relationship with immune infiltration remain unknown. In this study, we intended explore link examine expression pan-cancer using RNAseq data TPM format from TCGA GTEx. mRNA protein expressions adjacent normal tissue...