A5100687444- Bone Metabolism and Diseases
- Lipoproteins and Cardiovascular Health
- Cancer, Lipids, and Metabolism
- Diabetes Treatment and Management
- Metabolomics and Mass Spectrometry Studies
- Metabolism, Diabetes, and Cancer
- Multiple and Secondary Primary Cancers
- Bone health and treatments
- COVID-19 diagnosis using AI
- MicroRNA in disease regulation
- Pancreatic and Hepatic Oncology Research
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Cancer-related molecular mechanisms research
- Osteoarthritis Treatment and Mechanisms
- NF-κB Signaling Pathways
- Renal cell carcinoma treatment
- Traditional Chinese Medicine Studies
- Circular RNAs in diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Blood properties and coagulation
- Blood groups and transfusion
- Biomarkers in Disease Mechanisms
National Center for Clinical Laboratories
2006-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
Tan Tock Seng Hospital
2023-2024
Soochow University
2024
First Affiliated Hospital of Soochow University
2024
Zhongshan Hospital of Xiamen University
2022-2023
First Affiliated Hospital of Kunming Medical University
2023
Kunming Medical University
2023
Huzhou Central Hospital
2018-2022
Huzhou University
2019-2022
FBXO6, a component of the ubiquitin E3 ligases, has been shown to bind high mannose N-linked glycoproteins and act as ligase subunits. Most proteins in secretory pathway, such matrix metalloproteinases, are modified with N-glycans play important roles development osteoarthritis (OA). However, whether FBXO6 exerts regulatory effects on pathogenesis OA remains undefined.The expression was examined cartilage human multiple mouse models. The role degeneration analysed global FBXO6-/- mice,...
Background: Gastric cancer (GC) is a serious threat for public health worldwide. Long non-coding RNA (lncRNA) linc00152 has been well reported to be an oncogene and potential biomarker in multiple cancers including GC. However, the molecular mechanisms of GC development need further investigated.Methods: RT-qPCR assay was employed detect levels linc00152, microRNA-193b-3p (miR-193b-3p) ETS1 mRNA. protein level measured by western blot assay. Cell proliferative, migratory invasive capacities...
Proanthocyanidins (PCs) have shown inhibition of oxidative damage by improving Nrf-2 expression in many tissues. However, the cytoprotective effects PCs on H2O2-induced tendon not been verified. The current study was aimed at assessing cytoprotection cellular toxicity tendon-derived stem cells (TDSCs) induced H2O2. TDSCs were isolated from patellar tendons Sprague Dawley (SD) rats, and after third passage used for subsequent experiments. identified flow cytometry assay multidifferentiation...
Study Design. Xenograft osteosarcoma mouse model. Objective. We determined the effect of lycorine on osteosarcoma. Summary Background Data. Osteosarcoma is an aggressive malignant neoplasm, most prevalent in teenagers and adults current treatment approaches have reached a survival plateau attempts to improve prognosis proven unsuccessful. Thus there clear evidence that development new agents with high efficacy fewer side effects provide better prognostic outcome urgently needed. Methods. The...
To determine sensitivity of rapid diagnostic tests for detecting influenza A(H7N9) virus, we compared with PCR results and tested different types clinical samples. Usefulness seasonal virus infections is limited because their low in upper respiratory tract specimens.
Primary frozen shoulder (PFS) is a common condition of uncertain etiology that characterized by pain and restriction active passive glenohumeral motions. The pathophysiology involves chronic inflammation fibrosis the joint capsule. Single nucleotide polymorphisms (SNPs) at IL-1 β , MMP3 TGF- 1 GDF5 have been associated with risk variety inflammatory diseases; however, no studies examined these SNPs susceptibility to PFS. We investigated allele genotype frequencies rs1143627 rs650108 MMP-3...
Abstract Osteoporosis is caused by an imbalance between bone formation and resorption. Receptor activator of nuclear factor-κB ligand (RANKL) promotes the activity differentiation osteoclasts via activating (NF-κB) mitogen-activated protein kinase (MAPK) signaling pathways. IMD 0354 a selective molecular inhibitor NF-κB subunit beta (IKKβ) effective for treatment acute subacute inflammatory diseases through suppression activation. However, effect on homeostasis unknown. In this study, we...
Purpose. Oblique lumbar interbody fusion (OLIF) approach has been increasingly frequently performed in recent years. However, neither studies of OLIF nor the researches application enhanced recovery after surgery (ERAS) spinal are relatively rare. Here, our study is aimed at investigating therapeutic effects compared with transforaminal (TLIF) combined ERAS dealing this disorder short-term follow-up. Material and Methods. Thirty-eight patients who undergone forty TLIF pedicle screws were...
A balance between osteoblasts and osteoclasts is essential to maintain skeletal integrity, regulating bone metabolism remodeling. The nucleotide binding oligomerization domain, leucine-rich repeat pyrin domain containing protein 3 (NLRP3) inflammasome known as a cytosolic complex involved in producing proinflammatory cytokines consisting of interleukin- (IL-) 1β, which accelerates the occurrence osteoporosis. Therefore, we aimed investigate effect novel NLRP3 inhibitor INF 39 on formation...
Background Postprandial hyperglycemia plays an important role in the pathogenesis of coronary artery disease (CAD). The aim this study is to determine associations 1,5-Anhydroglucitol (1,5-AG), which reflects circulating glucose fluctuations, with prevalence CAD and severity angiography defined Chinese patients. Methods 2970 patients undergoing were enrolled. Baseline demographics medical history data was recorded. Serum 1,5-AG levels biochemical parameters measured. characteristics compared...
Chest X-rays (CXRs) are essential in the preliminary radiographic assessment of patients affected by COVID-19. Junior residents, as first point-of-contact diagnostic process, expected to interpret these CXRs accurately. We aimed assess effectiveness a deep neural network distinguishing COVID-19 from other types pneumonia, and determine its potential contribution improving precision less experienced residents. A total 5051 were utilized develop an artificial intelligence (AI) model capable...
The atherosclerotic coronary artery disease (CAD) risk assessment based on conventional factors have only moderate performance, and residual risks still exist. Thus, we reported here a cohort study that aims to identify validate the new biosignatures (especially metabolomics, lifestyle biomarkers biological age), elucidate their predictive effect CAD subsequent cardiovascular events.This prospective, single-center, commenced in March 2017 seeks examine patients undergoing angiography (CAG)...
PurposeIndividuals with chronic kidney disease (CKD) face an elevated residual risk of cardiovascular events, but the relationship between this and 1,5-anhydroglucitol (1,5-AG) is uncertain. Our study aimed to examine effect 1,5-AG on major adverse events (MACEs) all-cause mortality in acute coronary syndrome (ACS) individuals.Methods1253 ACS participants hospitalized were enrolled at Beijing Hospital March 2017 2020. All classified into 2 groups based their eGFR (60 ml/min/1.73 m2). The...
Automated and accurate classification of pneumonia plays a crucial role in improving the performance computer-aided diagnosis systems for chest X-ray images. Nevertheless, it is challenging task due to difficulty learning complex structure information lung abnormality from In this paper, we propose multi-view aggregation network with Transformer (TransMVAN) Specifically, incorporate knowledge glance focus views enrich feature representation abnormality. Moreover, capture relationships among...
This study aimed to evaluate the relationship between aromatic amino acids (AAAs), - phenylalanine (Phe), tyrosine (Tyr) and tryptophan (Trp) coronary artery disease (CAD) in a prospective involving 2970 participants undergoing angiography at Beijing Hospital. Serum levels of Phe, Tyr Trp were analysed. The cross-sectional data revealed that serum significantly inversely associated with CAD. During median follow-up period 44 months, 343 major adverse cardiovascular events (MACEs) 138...
Osteoarthritis (OA) is a disabling and malformation disease that affects multiple joints, especially hip knee joint, which characterized by degeneration progressive loss of articular cartilage with pathological changes in bone, synovium, soft tissues affected joints. Polymorphisms several genes, such as TIMP3 , interleukin-6 ( IL-6 ), IL-16 CDH2 HIF1A WISP1 have been demonstrated to be protective factors OA. However, polymorphisms other genes including ADAM12 DVWA ACE were considered...
For decades,there have been no systematic studies on the reference intervals of Chinese populations.With support Ministry Health,the Society Laboratory Medicine launches a research project investigating for common clinical laboratory tests.Up to now,the first batch liver function,electrolytes and blood cell analysis published in forms healthy professional standards.Medical institutions are suggested use these new practice. (Chin J LabMed,2013,36:393-394) Key words: Reference...