A5066681185- Ubiquitin and proteasome pathways
- Gut microbiota and health
- interferon and immune responses
- Menstrual Health and Disorders
- Plant Surface Properties and Treatments
- Hippo pathway signaling and YAP/TAZ
- Heat shock proteins research
- Retinal Development and Disorders
- Diet and metabolism studies
- Developmental Biology and Gene Regulation
- Endometriosis Research and Treatment
- Wnt/β-catenin signaling in development and cancer
- Tryptophan and brain disorders
- Signaling Pathways in Disease
- Retinoids in leukemia and cellular processes
- Ovarian function and disorders
- Growth Hormone and Insulin-like Growth Factors
- TGF-β signaling in diseases
Universidade Federal de Minas Gerais
2023-2025
Université Paris Cité
2008-2010
Délégation Paris 5
2008
Assistance Publique – Hôpitaux de Paris
2008
Polycystic ovary syndrome (PCOS) is a complex disease and the most common endocrine condition that affects women of reproductive age. Its prevalence ranges from 5% to 20%, characterized by hyperandrogenism, menstrual irregularities, presence polycystic dysfunctional ovaries [1] [2] [3] [4] [5] [6].
The bicoid-like transcription factor PITX2 has been previously described to interact with the pituitary-specific POU homeodomain POU1F1 (human ortholog of PIT-1) achieve cell-specific expression prolactin (PRL) and GH in pituitary somatolactotroph cells. In this work, we have investigated functional properties three mutants reported Axenfeld–Rieger syndrome patients relative regulation these genes, using reporter genes under control human PRL (hPRL), hGH, or promoters transfected...