A5045089957- Ovarian function and disorders
- Reproductive Biology and Fertility
- Bone health and osteoporosis research
- Growth Hormone and Insulin-like Growth Factors
- Reproductive Physiology in Livestock
- Vitamin D Research Studies
- Chronic Kidney Disease and Diabetes
- Reproductive System and Pregnancy
- Nutrition and Health in Aging
- Diabetes Management and Research
- Hip and Femur Fractures
- Bone health and treatments
- HIV-related health complications and treatments
- Lipid metabolism and disorders
- Acute Kidney Injury Research
- Diabetes Treatment and Management
- Adipokines, Inflammation, and Metabolic Diseases
- Advanced Glycation End Products research
- Diabetes and associated disorders
- Bone and Joint Diseases
- Hair Growth and Disorders
- Heavy Metals in Plants
- Genetic and phenotypic traits in livestock
- Folate and B Vitamins Research
- Gynecological conditions and treatments
Universidade Federal de Minas Gerais
2020-2025
Faculdade de Ciências Médicas de Minas Gerais
2024
Universidade Federal de Santa Maria
2013-2022
Hospital das Clínicas da Universidade Federal de Minas Gerais
2021
Imperial College London
2013-2015
University of Glasgow
2015
Universidade Federal do Rio Grande do Sul
1994-2005
Hospital de Clínicas de Porto Alegre
2004-2005
Hospital de Clínicas
2003
Polycystic ovary syndrome (PCOS), characterized by ovarian androgen excess, is the commonest endocrine disorder in women. Obesity increases synthesis, a phenomenon attributed to accompanying hyperinsulinemia. Our hypothesis was that adipokines, fat cell-derived hormones, play direct role modulating secretion. Therefore, aims of this study were explore effects adipokines (in particular, adiponectin) on steroidogenesis and compare expression adiponectin receptors ovaries from women with...
Until recently obesity was believed to be protective against fractures. However, a report from Fracture Liaison Clinic in the UK (2010) reported surprisingly high proportion of obese postmenopausal women attending clinic with fractures, and GLOW study (2011), similar prevalence incidence fractures non-obese observed. Subsequently, other studies have demonstrated importance epidemiology Obese are at increased risk fracture ankle, leg, humerus, vertebral column lower wrist, hip pelvis when...
Introduction Hirsutism is a prevalent condition among women and represents primary clinical feature of polycystic ovary syndrome (PCOS).
Polycystic ovary syndrome (PCOS) is a complex disease and the most common endocrine condition that affects women of reproductive age. Its prevalence ranges from 5% to 20%, characterized by hyperandrogenism, menstrual irregularities, presence polycystic dysfunctional ovaries [1] [2] [3] [4] [5] [6].
Although fractures had high mortality and morbidity, many studies proved that fracture risk might be decreased by pharmacological therapy, although a low treatment adherence rate is observed. The aim of this study was to identify factors associated with osteoporosis in postmenopausal women. A cross-sectional carried out from March August 2013 at the primary care setting. Postmenopausal women were recruited. standardized questionnaire applied. Women who using least one following drugs moment...
Does the expression of LHCG receptor (LHCGR) protein and key enzymes in androgen biosynthetic pathway differ normal human versus polycystic ovarian tissue? LHCGR 17α-hydroxylase/17-20-lyase (CYP17A1) levels are increased ovaries (PCOs). The predominant source excess secretion women with ovary syndrome (PCOS) is theca cells but few studies have directly assessed presence abundance for molecules involved production by theca, including rate-limiting enzyme production, CYP17A1. This a...
The prevalence of cardiovascular and metabolic diseases is increased in postmenopausal women, which contributes to the burden illnesses this period life. Yerba mate (Ilex paraguariensis) a native bush from Southern South America. Its leaves are rich phenolic components, may have antioxidant, vasodilating, hypocholesterolemic, hypoglycemic proprieties. This post hoc analysis case-control study nested Obesity Bone Fracture Cohort evaluated consumption yerba hypertension, dyslipidemia, coronary...
Interferon tau (IFNT) is the cytokine responsible for maternal recognition of pregnancy in ruminants and plays a role modulating embryo-maternal communication oviduct inducing local response from immune cells. We aimed to investigate IFNT production, reactive oxygen species, oxidative stress under influence heat (HS) during different stages bovine vitro embryo production. HS was established when temperature gradually raised 38.5°C 40.5°C laboratory incubator, sustained 6 hr, decreased back...
Abstract The Steno Diabetes Center Copenhagen developed the T1 Risk Engine (ST1RE) to predict cardiovascular events, encompassing fatal and nonfatal ischemic heart disease, stroke, failure, peripheral arterial disease in type 1 diabetes mellitus(T1DM). current study investigated agreement between ST1RE Brazilian Society for Endocrinology Metabology (SBEM) classification. Participants were included if diagnosed with T1DM had at least one outpatient visit 2021. Patients established chronic...
The prenatally androgenised (PA) sheep is a well-recognised model for the study of developmental programming adult polycystic ovary syndrome (PCOS). Most studies to date have involved examination reproductive and metabolic effects in offspring after puberty, but more recently, it has been reported that there disruption follicle formation steroid gene expression ovaries foetal exposure mother excess androgen. Our examines evidence precocious primordial at day 90 gestation Poll Dorset sheep....
Background . Uric acid presents different roles in an organism. High serum uric concentrations may induce inflammatory pathways and promote kidney damage through mechanisms. Therefore, this study investigated the association among high concentrations, renal tubular damage, inflammation assessed via estimation of urinary injury molecule-1 (KIM-1) cytokines patients with type 2 diabetes (T2D). Methods Urinary KIM-1, IL-1, IL-6, IL-10, TNF-alpha, as well other biochemical parameters, were 125...
Adiponectin is the most abundantly produced human adipokine with anti-inflammatory, anti-oxidative, and insulin-sensitizing properties. Evidence from in vitro studies has indicated that adiponectin a potential role reproduction because it reduces production of androstenedione bovine theca cells vitro. However, this effect on androgen not yet been observed vivo. The current study evaluated secretion oxidative stress parameters rodent model. Seven-week-old female Balb/c mice (n = 33),...
Background: Several studies have described an enhanced inflammatory status and oxidative stress balance disruption in women with polycystic ovary syndrome (PCOS). However, there is scarce information about redox markers the blood of androgenized animal models. Here, we evaluated serum/plasma marker metabolic parameter characteristics prenatal (PreN) postnatal (PostN) rat models PCOS. Materials methods: For PreN androgenization (n=8), 2.5 mg testosterone propionate was subcutaneously...
Nutritional factors have been associated with osteoporosis and fractures. The intake of coffee may increase the risk fracture whereas black green tea is its reduction. Recently, consumption yerba mate was increased bone mineral density in postmenopausal women. Nonetheless, influence on not known. aim this study to evaluate effect fractures, markers, calcium homeostasis, oxidative stress A case-control carried out South Brazil, 46 women fractures 49 controls completed study. There no...