A5054234470- Reproductive Physiology in Livestock
- Effects of Environmental Stressors on Livestock
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Genetic and phenotypic traits in livestock
- Reproductive System and Pregnancy
- Hippo pathway signaling and YAP/TAZ
- Growth Hormone and Insulin-like Growth Factors
- Connective Tissue Growth Factor Research
- Renal and related cancers
- Endometriosis Research and Treatment
- Mesenchymal stem cell research
- Pluripotent Stem Cells Research
- Bone health and osteoporosis research
- Trace Elements in Health
- Ruminant Nutrition and Digestive Physiology
- Hair Growth and Disorders
- Congenital Anomalies and Fetal Surgery
- Fibroblast Growth Factor Research
- IL-33, ST2, and ILC Pathways
- Plant Toxicity and Pharmacological Properties
Universidade Federal de Santa Maria
2017-2024
Mississippi College
2018
Safety concerns over cell-derived pharmaceutical products being manufactured in supplements of fetal bovine serum (FBS) have ignited pleas to replace FBS. Herein, four newly marketed alternatives FBS were compared: a xeno-free product called Cell-Ess®, human platelet lysate as GroPro®, and two mixtures adult varying their proportions neonatal growth factors, Liporo® FetalGro®. An endothelial cell line (C2BBe1) neuronal (SHSY5Y) near confluency media with 10% selectively scraped taken through...
Interferon tau (IFNT) is the cytokine responsible for maternal recognition of pregnancy in ruminants and plays a role modulating embryo-maternal communication oviduct inducing local response from immune cells. We aimed to investigate IFNT production, reactive oxygen species, oxidative stress under influence heat (HS) during different stages bovine vitro embryo production. HS was established when temperature gradually raised 38.5°C 40.5°C laboratory incubator, sustained 6 hr, decreased back...
We hypothesized that the hCG modulates expression of IFNT-pathway and ISGs in bovine endometrium during early pregnancy. The aim current study is to evaluate effect on signals endometrial cells. For this, 29 non-lactating cross-bread cows were used submitted a 9-day fixed-time artificial insemination (FTAI) protocol. day AI was considered Day 0 (D0), five days (D5) after FTAI, allocated into two groups: Control group, when group received single dose 2.500UI hCG. On 18 FTAI (D18) slaughtered...
The main clinical feature associated with hyperandrogenism in polycystic ovary syndrome (PCOS) humans is hirsutism, where hair increases its length, pigmentation, and particularly diameter. Currently, it not known whether PCOS animal models also exhibit changes the hair. Therefore, aim of this study was to explore wool characteristics sheep prenatally androgenized (PA) testosterone propionate. After 4 13 months life, collected from top shoulder both females males (both controls). offspring...
One of the major causes early pregnancy loss is heat stress. In ruminants, interferon tau (IFNT) embryo signal to mother. Once signaling pathway activated, it drives gene expression for interferon-stimulated genes (ISGs) and alters neutrophils responses. The aim present study was evaluate (IFN) pathway, ISGs in polymorphonuclear leukocytes (PMN) oxidative stress dairy cows under Pregnant had their estrous cycle synchronized randomly assigned a comfort or group. Blood samples were collected...
The aim of this study was to evaluate a new source injectable organic zinc (zinc edetate) on the energy and oxidative profile in sheep during immediate postpartum period. Twenty-six Texel breed animals were previously identified divided into two experimental groups: treated group (TG; n= 13) that comprised received subcutaneous (SC) injection 100 mg edetate (2 mL) fifteen days before parturition expected date control (CG; n=13) 2mL physiological solution at same TG. Blood samples collected...
ABSTRACT: This study identified the relationship between energy balance and some blood metabolites in primiparous dairy cows with different calving conception interval. Twenty Holstein-Friesian were grouped according to interval (days) from into early-conception (early-c; <100 days), mid-conception group (mid-c; 100 - 150 days) or late-conception (late-c; >150 group; evaluated on day -7 prior parturition, days 28, 56 90 postpartum. All groups presented positive balance, serum...
The establishment of pregnancy in cows requires uterine activity regulation the main Hippo signalling effector yes-associated protein 1 (YAP). It remains unknown (1) how YAP at corpus luteum (CL) correlates with early pregnancy-related events ruminants; and (2) if uterus CL can be affected by metabolic disorders that may lead to failure ruminants.To determine effect on total phospho-YAP expression its transcriptional CL, we compared non-pregnant vs pregnant ewes. To understand dysregulation...
The Hippo pathway is involved in the proliferation of intrafollicular cells and early embryonic development, mainly because effectors this are key transcription regulators genes such as CTGF CYR61, which cell proliferation. Recent studies by our group found that fibroblast growth factor 18 (FGF18) present fallopian tube during leading to hypothesis FGF18 may have a role development. Therefore, aim following study was determine whether modulates expression target genes, oocyte maturation...
Whether polycystic ovary syndrome (PCOS) affects bone health during a woman's lifespan remains controversial. An androgenized rodent model replicated many metabolic and reproductive features of women with PCOS, we aimed to use it investigate the impact androgens on microarchitecture (by micro-CT), mechanical strength, formation resorption markers in rats intact ovaries (SHAM) who underwent oophorectomy.Wistar (Rattus norvegicus albinus) were employed for experiments this study. The protocol...
Abstract Evidence from the literature is contentious about impact of polycystic ovary syndrome (PCOS) on skeleton, suggesting a possible negative role this condition non-obese women. We investigated hypothesis employing well-characterized testosterone propionate (TP) rodent model PCOS to address consequences androgenization bone microarchitecture, histology, and mechanical strength. For study, Wistar rats (n= 38) were divided in 4 groups: 1) “Control OVX” (single dose corn oil s.c. at day 5...
ABSTRACT: This study aimed to assess liver damage and interferon-stimulated gene 15 (ISG15) blood expression as a consequence of embryonic signaling on maternal recognition pregnancy in beef cattle presenting natural ingestion Senecio spp. Epidemiological aspects, the presence plant, associated gamma glutamyl transferase (GGT) activity can be used poisoning diagnosis. Maternal period occurs when embryo secretes interferon tau (IFNT) signal its mother eventually extend corpus luteum (CL)...