A5069464585- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Lipids, and Metabolism
- Lung Cancer Treatments and Mutations
- Multiple and Secondary Primary Cancers
- Radiomics and Machine Learning in Medical Imaging
- Peptidase Inhibition and Analysis
- Advanced Biosensing Techniques and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- HER2/EGFR in Cancer Research
- Male Breast Health Studies
- Cancer and Skin Lesions
- Head and Neck Cancer Studies
- Immune Response and Inflammation
- Antibiotics Pharmacokinetics and Efficacy
- Biological Research and Disease Studies
- Ovarian cancer diagnosis and treatment
- Gene expression and cancer classification
- Radiopharmaceutical Chemistry and Applications
- Breast Lesions and Carcinomas
- Renal Transplantation Outcomes and Treatments
- Advanced Proteomics Techniques and Applications
- Silymarin and Mushroom Poisoning
University of California, Berkeley
2024
Cleveland Clinic
2000-2004
Abstract Altered lipid metabolism is a common hallmark of various cancers, including intrahepatic cholangiocarcinoma (ICC), highly lethal carcinoma that lacks effective treatment options. To elucidate the changes in ICC, we coupled expression firefly luciferase gene (FFL) to AKT1 (AKT-FFL) via an IRES linker, and then hydrodynamically injected mice with AKT-FFL Notch1 intracellular cytoplasmic domain (NICD) establish luciferase-positive ICC model. This model not only enabled us monitor...
Recent reports from widely separated sources indicate a renewed interest in the etiology of primary splenomegaly with cirrhosis liver and anemia (Banti's disease). Gibson Fawcett have isolated streptothrix-like organism (Nocardia) spleen which they believe to be causative agent. Pinoy Nanta Algiers Emile-Weil, Gregoire Flandrin Paris others cultivated fungus, Aspergillus, high percentage spleens cases applied terms “splenic mycosis” “mycotic splenomegaly” disease. These views not been...
<p>Gene expression levels of FATP5 were measured using qPCR in 5 normal livers (NL), 33 ICC, and related surrounding (SL).</p>
<p>Gene expression levels of Fatp5, and Fasn were measured using qPCR in AAV-shSCR AAV-shFatp5 ICC tumors.</p>
<div>Abstract<p>Altered lipid metabolism is a common hallmark of various cancers, including intrahepatic cholangiocarcinoma (ICC), highly lethal carcinoma that lacks effective treatment options. To elucidate the changes in ICC, we coupled expression firefly luciferase gene (FFL) to <i>AKT1</i> (<i>AKT-FFL</i>) via an IRES linker, and then hydrodynamically injected mice with AKT-FFL <i>Notch1</i> intracellular cytoplasmic domain...
<div>Abstract<p>Altered lipid metabolism is a common hallmark of various cancers, including intrahepatic cholangiocarcinoma (ICC), highly lethal carcinoma that lacks effective treatment options. To elucidate the changes in ICC, we coupled expression firefly luciferase gene (FFL) to <i>AKT1</i> (<i>AKT-FFL</i>) via an IRES linker, and then hydrodynamically injected mice with AKT-FFL <i>Notch1</i> intracellular cytoplasmic domain...
<p>Gene expression levels of FATP5 were measured using qPCR in 5 normal livers (NL), 33 ICC, and related surrounding (SL).</p>
<p>Gene expression levels of Fatp5, and Fasn were measured using qPCR in AAV-shSCR AAV-shFatp5 ICC tumors.</p>
10764 Background: To report a unique case of papilloma the breast with metastases to axillary lymph node. Methods: Case and review literature. Results: 80 year old Caucasian male presented right gynacomastia 3 months duration. The lesion was resected. Pathology consistent intraductal hyperplasia no evidence malignancy. Subsequently, after 2–3 weeks mass noted in axilla. This resected found be node had pathological characteristics original papilloma. Conclusion: Solitary papillomas are...
5516 Background: The development of a 2nd (or 3rd) primary malignancy (SPM) is well recognized problem in pts with SCHNC. Although the prognosis such not defined, SPM felt to be an important competing cause death. Methods: We retrospectively reviewed our registry 222 SCHNC treated definitive chemoradiotherapy (CRT) between 1989–2002, identify those SPM, and define their clinical characteristics outcomes. All received 4-day continuous intravenous 5-fluorouracil (1000 mg/m2/day) cisplatin (20...
9629 Background: Estrogen receptor (ER) and progesterone (PR) are important prognostic predictive factors for breast cancer patients (pts). Murine monoclonal antibodies (MuAb) currently used in immunohistochemistry (IHC) assays to determine ER/PR status. Rabbit (RAb) may have greater affinity human antigens than MuAb. We compared the concordance of MuAb- RAb-based IHC ER PR value these other pts with Stage I-III cancer. Methods: TMAs were produced from formalin-fixed paraffin-embedded tissue...
5014 Background: CA 125 has proven to be useful in predicting changes that affect prognosis and management of ovarian cancer; however, interpreting variations the tumor marker is still not well-defined. Our goal was further understand analytical variability a conventional hospital laboratory. Methods: Patients with or primary peritoneal cancer, who received active therapy at Cleveland Clinic Foundation from July 2003 December 2003, were included this IRB-approved study. A blood sample...
9629
5014 Background: CA 125 has proven to be useful in predicting changes that affect prognosis and management of ovarian cancer; however, interpreting variations the tumor marker is still not well-defined. Our goal was further understand analytical variability a conventional hospital laboratory. Methods: Patients with or primary peritoneal cancer, who received active therapy at Cleveland Clinic Foundation from July 2003 December 2003, were included this IRB-approved study. A blood sample...
5516 Background: The development of a 2nd (or 3rd) primary malignancy (SPM) is well recognized problem in pts with SCHNC. Although the prognosis such not defined, SPM felt to be an important competing cause death. Methods: We retrospectively reviewed our registry 222 SCHNC treated definitive chemoradiotherapy (CRT) between 1989–2002, identify those SPM, and define their clinical characteristics outcomes. All received 4-day continuous intravenous 5-fluorouracil (1000 mg/m2/day) cisplatin (20...
Avery, R. K.1; Pohlman, B.2; Bolwell, Tso, E.1; Goormastic, M.4; Adal, K. A.1; Mendez, Z.2; Goldman, M.3; Mossad, S. B.1; Kalaycio, M.2; Capozzi, D.3; Schmitt, Andresen, S.2; Longworth, D. L.1 Author Information