A5035805990- Treatment of Major Depression
- Animal Genetics and Reproduction
- Epigenetics and DNA Methylation
- Bipolar Disorder and Treatment
- Metabolism and Genetic Disorders
- Anesthesia and Neurotoxicity Research
- Evolution and Genetic Dynamics
- Suicide and Self-Harm Studies
- Diet and metabolism studies
- Effects and risks of endocrine disrupting chemicals
Florey Institute of Neuroscience and Mental Health
2024
University of California, Los Angeles
1990-2004
West Los Angeles College
2004
Male sex, early life chemical exposure and the brain aromatase enzyme have been implicated in autism spectrum disorder (ASD). In Barwon Infant Study birth cohort (n = 1074), higher prenatal maternal bisphenol A (BPA) levels are associated with ASD symptoms at age 2 diagnosis 9 only males low genetic pathway activity scores. Higher BPA predictive of cord blood methylation across CYP19A1 promoter I.f region (P 0.009) gene mediates 0.01) link between brain-derived neurotrophic factor...
Objective: To compare the rates of suicidal behaviour during vs. after discontinuation treatment with antidepressants, and to determine comparative for patients maintained on tricyclic (TCA) selective serotonin reuptake inhibitor (SSRI) antidepressants. Method: Charts were reviewed 521 major depressive disorder and/or dysthymic disorder. Periods active or SSRIs TCAs determined. Rates completed suicide, suicide attempts, hospitalization suicidality analyzed. Results: There was greater than a...
Compensatory renal hypertrophy leads to an increase in the size and metabolic capacity of tubular cells. Increased transport activities must be sustained by augmented rate energy production, which is largely dependent on mitochondrial processes. Although previous studies have suggested that mitochondria proliferate hypertrophying cell, data support this not been convincing. This study was designed determine whether hypertrophied proximal cell undergo or proliferation. Flow cytometric...