A5103010266- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- HIV/AIDS Research and Interventions
- Respiratory and Cough-Related Research
- Vitamin D Research Studies
- HIV/AIDS drug development and treatment
- HIV-related health complications and treatments
- Chinese history and philosophy
- Mental Health Treatment and Access
- Mesenchymal stem cell research
- Diabetes Treatment and Management
- Dermatology and Skin Diseases
- Rheumatoid Arthritis Research and Therapies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cervical Cancer and HPV Research
- HIV Research and Treatment
- Immune Cell Function and Interaction
- Ethics in Clinical Research
- Listeria monocytogenes in Food Safety
- Schizophrenia research and treatment
- Glaucoma and retinal disorders
- Inhalation and Respiratory Drug Delivery
- Suicide and Self-Harm Studies
- Hearing, Cochlea, Tinnitus, Genetics
- Patient Dignity and Privacy
Western University
2020-2024
Lawson Health Research Institute
2020-2024
LAC+USC Medical Center
2024
St Vincent’s Private Hospital Sydney
2021
Children’s Health Research Institute
2020
Westat (United States)
2006-2019
Sanofi (United States)
2018-2019
Instituto de Efectividad Clínica y Sanitaria
2011-2019
Vanderbilt University Medical Center
2019
Western Health
2019
Natural killer T (NKT) cells are distinct glycolipid reactive innate lymphocytes that implicated in the resistance to pathogens and tumors. Earlier attempts mobilize NKT cells, specifically, vivo humans met with limited success. Here, we evaluated intravenous injection of monocyte-derived mature DCs were loaded a synthetic cell ligand, α-galactosyl-ceramide (α-GalCer; KRN-7000) five patients who had advanced cancer. Injection α-GalCer–pulsed, but not unpulsed, dendritic (DCs) led...
Young men who have sex with (YMSM) are a key population for implementation of preexposure prophylaxis (PrEP) interventions. This open-label study examined adherence to PrEP and assessed sexual behavior among diverse sample YMSM in 12 US cities.Eligible participants were 18- 22-year-old HIV-uninfected MSM reported HIV transmission risk the previous 6 months. Participants provided daily tenofovir disoproxil fumarate/emtricitabine (Truvada). Study visits occurred at baseline, monthly through...
Adolescents represent a key population for implementing preexposure prophylaxis (PrEP) interventions worldwide, yet tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) PrEP is only licensed adults. To examine the safety of and adherence to along with changes in sexual risk behavior among adolescent men who have sex (MSM). Adolescent Medicine Trials Network HIV/AIDS Interventions 113 (Project PrEPare) was demonstration project that evaluated safety, tolerability, acceptability TDF/FTC...
Recent studies have shown inflammatory markers in affected neural tissues of amyotrophic lateral sclerosis (ALS) patients. We examined immunocytochemically spinal cord six patients with ALS, two corticospinal tract degeneration secondary to cerebral infarcts and three control subjects without neuropathologic abnormalities. ALS cords had dense macrophage infiltration (one log greater than cords) involving the white gray matter, heaviest ventral columns and, one patient, prefrontal gyrus...
The active form of vitamin D, 1,25-dihydroxyvitamin D3, [1,25(OH)2D3] has potent actions on innate and adaptive immunity. Although endocrine synthesis 1,25(OH)2D3 takes place in the kidney, enzyme that catalyzes this, 25-hydroxyvitamin D-1α-hydroxylase (CYP27b1 humans, Cyp27b1 mice), is expressed at many extra-renal sites including colon. We have shown previously colonic expression CYP27b1 may act to protect against onset colitis. To investigate this further, we firstly characterized changes...
The objective of this study was to determine whether the 3-dose quadrivalent human papillomavirus (HPV) vaccine series (HPV-6, -11, -16, -18) is immunogenic and safe in young women infected with immunodeficiency virus (HIV). We enrolled 99 aged 16–23 years a phase 2, open-label, multicenter trial, conducted from 2008 2011 by Adolescent Medicine Trials Network for HIV/AIDS Interventions. Outcome measures were immunogenicity 4 weeks after dose 3, measured (1) geometric mean titers (GMTs) (2)...
Abstract Objective Safety and efficacy of mAbs blocking the IL-6 receptor have been established in RA. This is first analysis examining safety tolerability sarilumab tocilizumab administered as single or multiple doses patients with RA within same study. Methods In ASCERTAIN, were randomized 1: 2 to 24 weeks’ double-blind 150 200 mg every weeks s.c. 4 mg/kg i.v., increased 8 if clinically indicated. Study 1309, 1 single-dose open-label i.v. Results incidence treatment-emergent adverse events...
Objective. To conduct a clinical trial of intratympanic steroid injection for idiopathic sudden sensorineural hearing loss in subjects who failed oral therapy. Study Design and Setting. Open‐label methylprednisolone tertiary neurotologic referral center. Twenty (14 males; 6 females) received 4 injections within 2‐week period (4 days apart). Hearing, dizziness/p, tinnitus were evaluated before after treatment. Results. There no serious unexpected adverse events 2 types expected (tympanic...
Abstract The purpose of this study was to evaluate the role BMPs on formation metastatic prostate cancer lesions bone. Our results show that influence development and progression osteoblastic suggest therapies inhibit BMP activity may reduce lesions. Introduction: Prostate adenocarcinoma is leading cause in North American men. skeletal metastases affects ∼70% patients with advanced disease, a majority these have Although been found be expressed multiple oncogenic cell lines, their remains...
OBJECTIVE To determine hearing recovery in patients with idiopathic sudden loss treated varying amounts of oral steroids. STUDY DESIGN AND SETTING A retrospective chart review (n = 75) a tertiary care clinic examined 1 60‐mg prednisone taper, course steroid less than or any 2 courses steroid. RESULTS Overall, 35% the recovered clinically significant amount hearing. Recovery was associated immediate treatment (within weeks from onset), better at onset treatment, and higher dose just...
Losartan treatment reduced renal outcomes in proteinuric patients with type 2 diabetes the Reduction of Endpoints NIDDM Angiotensin II Antagonist (RENAAL) study. It is unknown whether an insertion (I)/deletion (D) polymorphism angiotensin I-converting enzyme (ACE) gene predicts and death influences effect losartan these patients. Pharmacogenetic analyses were performed comparing placebo administered conventional blood pressure-lowering therapy 1435 (95%) 1513 RENAAL study The primary...
The study goal was to determine the effect of vitamin D (VITD) supplementation on tubular reabsorption phosphate (TRP), parathyroid hormone (PTH), bone alkaline phosphatase (BAP), and C-telopeptide (CTX) in youth infected with human immunodeficiency virus (HIV) receiving not combination antiretroviral therapy (cART) containing tenofovir disoproxil fumarate (TDF).This randomized, double-blind, placebo-controlled multicenter trial enrolled HIV-infected 18-25 years based stable treatment cART...
ABSTRACT Tenofovir disoproxil fumarate (TDF) causes bone, endocrine, and renal changes by an unknown mechanism(s). Data are limited on tenofovir pharmacokinetics these effects. Using baseline data from a multicenter study of HIV-infected youth stable treatment with regimens containing TDF ( n = 118) or lacking 85), we measured cross-sectional associations use markers function, vitamin D-calcium-parathyroid hormone balance, phosphate metabolism (tubular reabsorption fibroblast growth factor...
Scaffolds play an important role in directing three-dimensional (3D) cartilage regeneration. Our recent study reported the potential advantages of bone marrow clots (MC) promoting extracellular matrix (ECM) scaffold chondrogenic The aim this is to build a new for MC, with improved characteristics mechanics, shaping, and biodegradability, compared our previous study. To address issue, prepared 3D porous polycaprolactone (PCL)-hydroxyapatite (HA) combined MC (Group A), while control group B)...
We aimed to define the relative importance of renal and endocrine changes in tenofovir disoproxil fumarate (TDF)-related bone toxicity.In a study daily TDF/emtricitabine (FTC) preexposure prophylaxis (PrEP) human immunodeficiency virus (HIV)-uninfected young men who have sex with men, we measured from baseline blood urine markers parathyroid hormone (PTH)-vitamin D-fibroblast growth factor 23 (FGF23) axis, creatinine, tubular reabsorption phosphate (TRP). explored relationship those...
Background: Health care workers (HCWs) are among the most vulnerable groups to experience burnout during coronavirus (COVID-19) pandemic. Understanding risk and protective factors of is crucial in guiding development interventions; however, understanding determinants Canadian HCW population remains limited.
Mesenchymal stem cells (MSCs), a cell population capable of multi‑lineage differentiation, bound to porous biomaterial scaffolds, are widely used for bone tissue regeneration. However, there is evidence suggest that MSC collection from marrow and expansion in vitro may result phenotypic changes including loss differentiation potential senescence. The aim the present study was find facile efficient approach enable adhesion proliferation scaffolds with osteogenic differentiation. Unprocessed...