A5014039208- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Immune responses and vaccinations
- Marine Bivalve and Aquaculture Studies
- Long-Term Effects of COVID-19
- Ocean Acidification Effects and Responses
- Microplastics and Plastic Pollution
- Viral Infections and Outbreaks Research
- Diabetes and associated disorders
- Wound Healing and Treatments
- Virus-based gene therapy research
- Nanoparticles: synthesis and applications
- Microbial Metabolism and Applications
- Animal Virus Infections Studies
- Inflammasome and immune disorders
- Immune cells in cancer
- Immune Cell Function and Interaction
- Coral and Marine Ecosystems Studies
- Environmental Toxicology and Ecotoxicology
- Tryptophan and brain disorders
- Marine Biology and Ecology Research
Al-Azhar University
2015-2024
Woods Hole Oceanographic Institution
2015-2017
We aimed to determine the levels of follicular helper T (Tfh) and regulatory (Tfr) cells in COVID-19 patients whether their correlated with disease severity presence hyperglycemia. This study was carried out 34 hospitalized 20 healthy controls. Levels total circulating Tfh, inducible T-cell costimulator (ICOS)+ activated Tfr were assessed all participants by flow cytometry. Total CD4+CXCR5+ Tfh ICOS+Foxp3-activated increased ICOS+Foxp3+ decreased patients, especially diabetic those severe...
Hematopoietic stem cells (HSCs) and hematopoietic progenitor (HPCs) play a crucial role in the context of viral infections their associated diseases. The link between HSCs HPCs disease status COVID-19 patients is largely unknown. This study aimed to monitor kinetics contributions severe non-severe evaluate diagnostic performance differentiating healthy as well cases. Peripheral blood (PB) samples were collected from 48 patients, 16 recovered, 27 controls subjected deep flow cytometric...
Human SARS-CoV-2 and avian infectious bronchitis virus (IBV) are highly contagious deadly coronaviruses, causing devastating respiratory diseases in humans chickens. The lack of effective therapeutics exacerbates the impact outbreaks associated with IBV infections. Thus, novel drugs or therapeutic agents demand for controlling viral transmission disease progression. Mesenchymal stem cells (MSC) secreted factors (secretome) safe efficient alternatives to MSC-based therapies. This study aimed...
Our study's objectives were to study the clinical and laboratory characteristics that may serve as biomarkers for predicting disease severity, IL-10 levels, frequencies of different T cell subsets in comorbid COVID-19 patients.Sixty-two hospitalized patients with comorbidities assessed clinically radiologically. Blood samples collected assess lymphocyte by flow cytometry levels ELISA.The most common observed diabetes mellitus (DM), hypertension, malignancies. Common symptoms signs included...
The immune response implicated in Coronavirus disease 2019 (COVID-19) pathogenesis remains to be fully understood. present study aimed clarify the alterations CD4+ and CD8+ memory T cells’ compartments SARS-CoV-2-infected patients, with an emphasis on various comorbidities affecting COVID-19 patients. Peripheral blood samples were collected from 35 16 recovered individuals, 25 healthy controls, analyzed using flow cytometry. Significant detected percentage of cells effector memory-expressing...
Background: We aimed to monitor the phenotypic changes in macrophages and their polarization patients with acute viral respiratory diseases, including coronavirus disease diagnosis, focusing on variations percentages of monocytes sub-populations those compared healthy control. Moreover, we defined correlation between macrophage subtypes some inflammatory indices. Methods: Twenty-seven clinical radiologic diagnosis infection admitted Al-Azhar Assiut University hospitals were recruited. Fresh...
Staphylococcus aureus is causing high rates of morbidity and mortality in human.Stem cells secreted factors are safe efficient alternative to stem cells-based therapies.In this study, study aimed evaluate the antibacterial activity by human Wharton's jelly mesenchymal secretome (hWJ-MSCs) against aureus, hWJ-MSCs were cultured collected their be used for In vitro screening aureus.Antibacterial activity, antibiofilm, minimum inhibitory concentrations (MIC) hWJ-MSC-S determined.The present...