Arvin Azarmina
A5107287261- IL-33, ST2, and ILC Pathways
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Eosinophilic Esophagitis
- Cancer Genomics and Diagnostics
- CAR-T cell therapy research
University Health Network
2025
Immunotherapies have had unprecedented success in the treatment of multiple cancer types, albeit with variable response rates. Unraveling complex network immune cells within tumor microenvironment (TME) may provide additional insights to enhance antitumor immunity and improve clinical response. Many studies shown that NK or innate lymphoid (ILC) regulatory capacity. Here, we identified CD103 as a marker was found on CD56+ were associated poor proliferative capacity tumor-infiltrating...
<div>Abstract<p>Immunotherapies have had unprecedented success in the treatment of multiple cancer types, albeit with variable response rates. Unraveling complex network immune cells within tumor microenvironment (TME) may provide additional insights to enhance antitumor immunity and improve clinical response. Many studies shown that NK or innate lymphoid (ILC) regulatory capacity. Here, we identified CD103 as a marker was found on CD56<sup>+</sup> were associated...
<p>Fig. S10. CD103+Lin- ILC1-like cells are associated with altered immune landscape within the TME.</p>
<p>Fig. S5. Identifying cellular clusters from scRNA-seq of ovarian tumours.</p>
<p>Fig S4. CD101 and GITR expression is expressed on CD103+CD49a+CD56+Lin- ILCs but not other NK cell subsets.</p>
<p>Fig. S1. Gating strategy for intratumoural ILCs.</p>
<p>Fig. S7. Intratumoural CD103+CD56+Lin- ILCs displayed unique profile of transcription factors.</p>
<p>Fig. S2. CD103+CD56+Lin- ILCs express distinct gene expression compared to CD103-CD56+Lin-ILCs.</p>
<p>Fig. S9. CD103+CD56+Lin- ILCs express distinct signatures compared to other ILC subsets.</p>
<p>Fig. S3. CD103+CD56+Lin- ILCs exhibit features that are associated with Tregs.</p>
<p>Fig. S8. CD56+ ILCs cluster 0 from CITE-seq are composed of predominately CD103+CD49a+ expressing cells.</p>
<p>Fig. S6. CD103+CD56+ ILCs have distinct transcriptional networks revealed by SCENIC analysis.</p>