A5100367284- Angiogenesis and VEGF in Cancer
- Mesenchymal stem cell research
- Breast Cancer Treatment Studies
- Lung Cancer Treatments and Mutations
- Cancer therapeutics and mechanisms
- Colorectal Cancer Treatments and Studies
- Endometrial and Cervical Cancer Treatments
- Congenital heart defects research
- Chemokine receptors and signaling
- RNA modifications and cancer
- Chronic Kidney Disease and Diabetes
- Liver Disease and Transplantation
- Acute Kidney Injury Research
- Advanced Radiotherapy Techniques
- Cancer Cells and Metastasis
- TGF-β signaling in diseases
- Cancer-related gene regulation
- Cancer, Lipids, and Metabolism
- Lipid metabolism and disorders
- Zebrafish Biomedical Research Applications
- Histone Deacetylase Inhibitors Research
- Biomarkers in Disease Mechanisms
- Diabetic Foot Ulcer Assessment and Management
- Chronic Myeloid Leukemia Treatments
- Lymphatic System and Diseases
Affiliated Zhongshan Hospital of Dalian University
2009-2024
Stomatological Hospital of Chongqing Medical University
2024
Chongqing Medical University
2024
Second Affiliated Hospital of Chongqing Medical University
2024
Dalian Medical University
2024
Sichuan University
2010-2021
General Hospital of Central Theater Command
2020
Central Hospital of Wuhan
2020
King's College London
2010-2011
British Heart Foundation
2011
Abstract Apoptosis is a critical event in the pathogenesis of lung ischemia/reperfusion (I/R) injury. Sirtuin 3 (SIRT3), an important deacetylase predominantly localized mitochondria, regulates diverse physiological processes, including apoptosis. However, detailed mechanisms by which SIRT3 I/R injury remain unclear. Many polyphenols strongly regulate sirtuin family. In this study, we found that polyphenol compound, procyanidin B2 (PCB2), activated mouse lungs. Due to effect, PCB2...
Stromal cell derived factor-1 (SDF-1) is a chemokine that plays critical role in the homing of stem and progenitor cells, including endothelial cells (EPCs). However, little research has been undertaken to evaluate roles SDF-1 biological functions EPCs related signaling pathways. The present study aimed investigate response SDF-1, as well underlying mechanisms. effects treatment on EPC proliferation, migration tube formation were assessed by performing MTS, Transwell vitro assays,...
Smooth muscle cell (SMC) differentiation is a critical process during cardiovascular formation and development, but the underlying molecular mechanism remains unclear.Here we demonstrated that chromobox protein homolog 3 (Cbx3) crucial for SMC from stem cells chromodomain chromoshadow domain of Cbx3 are responsible Cbx3-induced differentiation. Moreover, identified 4 amino acids (165 to 168) within key elements interaction with Dia-1- Mechanistically, found mediates through modulating serum...
Normalising tumour vessels had become a significant research focus in treatment recent years. Curcumae rhizoma (CR) is an essential plant traditional Chinese medicine as it promotes blood circulation and removes stasis. Similarly, CR improves local circulation. We explored the anti-colon cancer effects of oil from (OCR) by investigating its role normalising vessels. also provided basis for development into new anti-cancer drugs. used colon to investigate OCR. established vitro co-culture...
This study aimed to investigate the association of mRNA expression echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusion gene with that thymidylate synthase (TYMS) in non-small cell lung cancer (NSCLC) tissues. Quantitative polymerase chain reaction was used detect EML4-ALK and TYMS 257 cases NSCLC. The positive rate 4.28% NSCLC tissues (11/257), higher nonsmokers than smokers (P<0.05); detected 63.42% (163/257) cases. An detected; a low level...
CBP/p300 interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 (CITED1) is a transcriptional activator belonging to the non-DNA-binding transcription co-regulator family. It regulates diverse pathways, including transforming growth factor/bone morphogenetic protein/SMAD, estrogen, Wnt-β-catenin, and androgen-AR signaling by binding co-activators through its conserved transactivation CR2. CITED1 plays an important role in embryonic development certain regulatory occurrence of...
Small cell lung cancer (SCLC) is an aggressive neuroendocrine tumor with the poorest prognosis among all types of cancer. Developing effective comprehensive strategy remains a key focus. We herein present first documented case 68-year-old man limited-stage SCLC who has maintained complete response (CR) for over 30 months to date. CR was achieved first-line chemotherapy using etoposide and carboplatin combined chest volumetric-modulated arc therapy. Maintenance therapy anlotinib extended...
The invasion of colon cancer is associated with the tumor angiogenesis. Endostatin an important anti-angiogenic agent, and additive effect endostatin a chemotherapeutic cyclophosphamide, on micrangium has not been established. Male BALB/c strain nude mice were injected human colorectal carcinoma cells (HCT-116). divided into four groups (n = 15, each group) treated different concentrations (15, 10, 5 mg/kg/day), cyclophosphamide (20, combination endostatin/cyclophosphamide (15 + 20, 15...
Cabozantinib has been shown to have potent anti-ROS1 activity in many solid malignancies, particularly against those with solvent-front resistance mutations following crizotinib therapy. With regard the most common CD74-ROS1 fusion, efficacy of cabozantinib only demonstrated vitro. Therefore, we evaluate a patient advanced non-small-cell lung cancer (NSCLC) harboring fusion present study. A 40-year-old female presented 1-month history cough, white sputum and chest pain. Chest CT scan...
The present study aimed to investigate the association between epidermal growth factor receptor (EGFR) gene mutations and excision repair cross-complementing protein 1 (ERCC1) ribonucleotide reductase subunit M1 (RRM1) mRNA expression in non-small cell lung cancer (NSCLC) tissue. quantitative polymerase chain reaction was used detect EGFR mutations, ERCC1 RRM1 257 cases of NSCLC. In NSCLC samples mutation rate 49.03% (126/257). higher females non-smoking patients (P<0.05). High observed...
Objective To detect the differential expression of vascular endothelial growth factor (VEGF) and microvcssel density (MVD) count in benign malignant breast lesions to clarify correlation VEGF with occurrence progression cancer angiogenesis. Methods lmmunohistochemistry (SP method) was used examine MVD 88 intra-operatively harvested samples invasive ductal carcinoma, 25 carcinoma situ, 15 atypical hyperplasia 100 obtained. Results The positive rate group 70. 5% it significantly higher than...
To detect the expression of vascular endothelial growth factor (VEGF) and microvessel density (MVD) count in breast benign affection, atypical hyperplasia carcinoma situ, to clarify relationship between VEGF expression, MVD clinicopathological features these diseases. The 115 cases diseases (including 40 fibroid tumor, cystic 35 intraductal papilloma, 19 hyperplasias 32 carcinomas situ were examined by immunohistochemistry staining (SP-method). positive rate diseases, 21.74%(25/115)、 31.58.%...
Objective Observation and Study of Killing Proapoptotic Effects Topoisomerase Ⅰ (topotecan) inhibitor on L1210/CDDP cells. Methods Analyze Topotecan' s killing activity inductive effect cell lines the relationship between above two Caspase, using MTF method,Annexin V FITC staining, DNA ladder electrophoresis morphology methods. Results TPT line has strong anti-role, a clear time-dependence. At same time, target cells present sign apoptosis. Caspase-specific can cause certain Conclusion...