The current research was undertaken to design stealth liposomes of 5-Fluorouracil for reducing its cardiotoxicity and prolong the half-life by developing long-circulating liposomes. were prepared NH4EDTA gradient method, where EDTA is used as a cardioprotectant. Ascorbyl-6-palmitate also which helped synergistic effect counteract cancer cells provide promising application in treatment breast cells. Taguchi screening formulation HSPC phospholipid selected. drug-excipient compatibility checked...

Present investigation was aimed to develop aspasomal gel of Mometasone Furoate for the treatment Psoriasis that are biologically active and deliver drug at controlled rate decrease dosing frequency.The vesicles were fabricated using film hydration method optimized 32 factorial Design. Prepared formulations evaluated percent loading, vesicle size, Zeta potential, polydispersity index morphological studies. Gel prepared carbopol by loading loaded asposomes content, pH, viscosity spreadability....

24May 2018 TRANSDERMAL DRUG DELIVERY SYSTEMS: A MINI REVIEW. Rakesh Patel , Ankita Bijal Prajapati Gajanan Shinde and Abhay Dharamsi. Faculty of Pharmacy, Parul Institute University, Vadodara -391760, Gujarat, India. Mil Laboratories Pvt. Ltd., Manjusar GIDC, Plot no ? 541-542 Taluka- Savali, Gujarat.

In the present study, suitability of a green eutectic solvent, mixture menthol and camphor for cocrystal synthesis has been investigated to improve biopharmaceutical properties poorly water-soluble drugs.

Plumbagin with nicotinamide cocrystals synthesised by electrospray technology demonstrated two-, three- and nine-fold enhancements in solubility, dissolution permeability coefficient.

A simple, precise bioanalytical UPLC Tandem Mass Spectroscopy gradient elution method was developed and validated for simultaneous estimation of Olmesartan Medoximil (OLM) Metoprolol Succinate (MET) in human plasma. The quantitation carried out using Shimadzu Shimpack-C18 GIST AQ (50 mm X 2.1 mm, 1.9 µm) column the mobile phase comprises 0.1% formic acid B as acetonitrile used elution. Analysis completed within run time 4 min at flow rate 0.3mL/min. retention metoprolol succinate olmesartan...

The aim of the present investigation was to formulate and characterize nanocrystal formulation Repaglinide for diabetes therapy. Formulation done by high pressure homogenization. HPH cycles range were screened preliminary batches (T1 T2). 5, 8, 10 500 1500 bar had kept further investigation. Taguchi design used optimize type polymer, % polymer concentration, number cycles, formulation. Formulations characterized particle size, zeta potential, in vitro drug release. Optimized (NC 3) showed...

Abstract: Introduction: Cancer is a term used for diseases in which abnormal cells divide without control and are able to invade other tissues. Gemcitabine new cytotoxic drug but some of limitations while its use likes it suppress the activity Bone marrow i.e. effect on blood forming cells, lower half life-7-18 min.unable deliver by oral & route. Higher dose-1000-1250 mg/m2 require against malignancies. Effective various solid tumor like colon, lungs, breast etc. Several attempt was made...

Skin has traditionally been used by various means to apply the medicaments for purposes. Recent years have witnessed transdermal as a main route of delivery drugs which are difficult deliver otherwise. Transdermal drug offers several advantages mainly avoidance first pass metabolism and gastric environment would inactivate drug. This review encompasses basic anatomy skin relevant discuss in detail formulation strategies permeation enhancement better therapeutic effect. Finally, sumps up with...

Voriconazole is an effective antifungal drug, used as first line treatment for Invasive Aspergillosis. The present work focusses on formulation of PEGylated liposomes to achieve longer circulation in the blood, prevent from opsonisation by mononuclear phagocytic system RES. higher plasma concentration voriconazole leads visual disturbance and dermatological side effect, which are minimized PEGylation. Compatibility studies like FTIR (Fourier Transform IR) DSC (Differential Scanning...

Objectives: Olmesartan medoxomil (OLM) and metoprolol succinate (MPS) in fixed-dose combination (FDC) tablet formulation prescribed extensively.Stability indicating (SI) method for impurities related substance (RS) test quantitates the amount of these analytes formulation; manuscript presents SI/RS-ultra-high performance liquid chromatography-photodiode array (UHPLC-PDA) OLM MPS their impurities.Materials Methods: Well-resolved separation all was achieved with gradient elution on a Shimadzu...

The present investigation was computational predictability of Polyethylene Glycol (PEG) encapsulated modified release multiple unit pellets system (MUPS) tablet Metoprolol succinate by quality design (QbD). Quality target product profile (QTPP) and critical attributes (CQAs) MUPS tablets were defined. Risk assessment done using Ishikawa diagram failure mode effect analysis (FMEA) as per ICH Q8 guidelines. Formulation screened optimized Plackett–Burman Box– Behnken design. Pellets prepared...