A5115601056- Analytical Methods in Pharmaceuticals
- Drug Solubulity and Delivery Systems
- Analytical Chemistry and Chromatography
- Advanced Drug Delivery Systems
- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical studies and practices
- Advancements in Transdermal Drug Delivery
- Computational Drug Discovery Methods
- Diabetes Treatment and Management
- melanin and skin pigmentation
- Acne and Rosacea Treatments and Effects
- Inflammatory mediators and NSAID effects
- Protein purification and stability
- Crystallization and Solubility Studies
- Piperaceae Chemical and Biological Studies
- Pharmaceutical Practices and Patient Outcomes
- Metabolism, Diabetes, and Cancer
- Biopolymer Synthesis and Applications
- COVID-19 epidemiological studies
- Synthesis of heterocyclic compounds
- Neuroscience and Neuropharmacology Research
- Neuroblastoma Research and Treatments
- Biosimilars and Bioanalytical Methods
- Pesticide Residue Analysis and Safety
- Antibiotic Use and Resistance
Parul University
2022
Indian Institute of Information Technology Vadodara
2012-2021
Institute of Medical Sciences
2021
Gujarat Technological University
2016-2021
Global University
2021
Physiotherapy New Zealand
2020
Children's National
2016
MedStar Washington Hospital Center
2016
Biotech Park
2012
Sir Sayajirao General Hospital Medical College
2010
An attempt was made to pharmaceutically develop a topical liposomal tretinoin (TRE) gel and clinically evaluate the developed formulation for treatment of acne in patients. Liposomes TRE were prepared using lipid film hydration technique entrapment efficiency liposomes optimized 79.96%. The drug retention (Carbopol 934 base) studied at three storage conditions indicated maximum refrigeration temperature. For gel, reduced leakage observed as compared that all conditions. Diffusion studies...
Accurate and precise reverse phase liquid chromatographic method has been developed for the estimation Remogliflozin etabonate in bulk tablet dosage form.Reverse C18 column was used as stationary along with mixture of methanol:water (70:30%, v/v) a mobile phase.Mobile flow rate maintained at 1mL/min analysis performed 229 nm.The linear concentration range 1 -25 μg/mL correlation coefficient (r 2 ) 0.997.The proposed validated respect to linearity, accuracy, precision robustness per ICH Q2...
The purpose of this study was to investigate the potential pharmacokinetic interactions with natural products (such as piperine (PIP), gallic acid (GA) and cinnamic (CA)) rosuvastatin (RSV) (a specific breast cancer resistance protein, BCRP substrate) in rats. In Caco 2 cells, polarized transport RSV effectively inhibited by PIP, CA GA at concentration 50 μM. After per oral (p.o.) coadministration (10 mg/kg) significantly increased intravenous exposure (AUC last ) (1 73.5%, 62.9% 53.3% ( p...
Background: The purpose of the present research work was to extract jackfruit mucilage, use it as a mucoadhesive agent, and develop extended release buccoadhesive tablets with an intention avoid hepatic first-pass metabolism, by enhancing residence time in buccal cavity. Materials Methods: mucilage isolated from pulp aqueous extraction method characterized for various physiochemical parameters well its adhesive properties. Three batches were prepared (wet granulation method) evaluated...
Abstract Background A sensitive, precise, and stability-indicating high-performance thin-layer chromatographic (HPTLC) method has been developed for the analysis of Remogliflozin etabonate in tablet formulation. HPTLC plates precoated with silica gel 60 F 254 were used as stationary phase; methanol: ethyl acetate: toluene: NH 3 (2:4:4:0.1, v/v/v) was mobile phase, densitometry quantitative estimation drug. The proposed validated respect to linearity, accuracy, precision, robustness applied...
A simple, accurate and selective LC–MS/MS method using a polarity switch technique was developed validated for the simultaneous quantification of piperine, cinnamic gallic acid in rat plasma. Bicalutamide piperine (positive mode) furosemide (negative were used as internal standards. The precursor product ions analytes monitored triple quadrupole mass spectrometer API 4000 Q-Trap instrument, operating multiple reaction monitoring mode with switch. over range ∼5–1000 ng ml−1 ∼50–10 000 acid....
Application of Simplex Lattice Design in Formulation and Development Buoyant Matrices DipyridamoleMandlik Satish K, Adhikari Saugat, Deshpande Ameya A.
Abstract: Introduction: Microsponges provides a proficient drug delivery system for specific in the upper gastrointestinal tract with high loading capability. But formulation is affected by numerous process and design related factors. The intention of current research work was to formulate optimize floating gastroretentive microsponges glipizide, an antidiabetic drug, minimum number experiments, applying appropriate experimental design. Methods: decisive factors affecting were screened...
Background: Aspirin combination is prescribed for its thrombolytic activity where gastric ulceration the major side effect of aspirin which can be prevented by combining it with proton pump inhibitor omeprazole. Present study describes development analytical method estimation and omeprazole in combination. Objective: The aim present was to develop validate chromatographic simultaneous analysis Methods: Isocratic, reversed phase stability indicating liquid developed determination Omeprazole...
The aim of the present study was to prepare floating matrix tablet glipizide by applying Simplex lattice design using kappa carrageenan, Hydroxypropylmethylcellulose K15M and sodium bicarbonate as independent variable. similarity factor (f2), time release 50 % drug 90 were taken dependent factors. A total 14 batches prepared given Design-Expert® Software (version- 9.0.6, Stat-Ease) response obtained for variables statistically evaluated. Radiological performed on healthy albino rabbits...
Lercanidipine Hydrochloride (LER) is widely used antihypertensive drug belonging to BCS Class II and showing pH dependent solubility. The bioavailability of LER limited because its poor water Inclusion complexes were prepared with β-Cyclodextrin (βCD) using kneading freeze drying techniques in different molar ratios enhance solubility improve dissolution characteristic the same. phase study was performed interaction between βCD solution. Phase graph showed a linear diagram classified as AL...
Objective: It is always challenging to prepare the floating gastro retentive formulation of high dose drug. The present research was aimed controlled release, matrix tablets metformin, using combination different ionic, anionic and polyanionic polymers with HPMC.Methods: Formulations were prepared sodium alginate, pullulan, kappa carrageenan, xanthan gum, poloxamer 68 in HPMC K15M. All by direct compression method evaluated for swelling, adhesive period drug release.Results: showed...
Abstract Stability indicating analytical method helps to identify the instrinsic stability of molecule and likely degradation pathway. Present study involves development a liquid chromatography for Valbenazine which can be used in analysis forced degraded samples along with its kinetic study. The was developed using Column (Shimadzu ODS Shim‐pack Solar (250* 4.6 mm, 5 µm)) as stationary phase acetonitrile/water (90:10) mobile phase. Flow rate maintained at 1 mL/min detection performed diode...
Lercanidipine hydrochloride (HCl) is L-type calcium channel blocker widely used in the management of hypertension.According to BCS classification system, it classified under class II drugs, showing low solubility and high permeability.The dissolution profile thus vivo performance this drugs depend on their hence behaviour medium.Lercanidipine HCl not official any pharmacopeia, so no method available.The present work mainly focussed development validation a test that can be as quality control...