A5027097889- Asthma and respiratory diseases
- Inflammatory mediators and NSAID effects
- Nitric Oxide and Endothelin Effects
- Pulmonary Hypertension Research and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Kruppel-like factors research
- Pediatric health and respiratory diseases
- Immune Cell Function and Interaction
- Cell Adhesion Molecules Research
- Eosinophilic Disorders and Syndromes
- Eosinophilic Esophagitis
- Circadian rhythm and melatonin
- Melanoma and MAPK Pathways
- Nonmelanoma Skin Cancer Studies
- Sphingolipid Metabolism and Signaling
- Antimicrobial Peptides and Activities
- S100 Proteins and Annexins
- Respiratory Support and Mechanisms
- Lung Cancer Treatments and Mutations
- Polyomavirus and related diseases
- Receptor Mechanisms and Signaling
- Helicobacter pylori-related gastroenterology studies
- Eicosanoids and Hypertension Pharmacology
Medical University of Graz
2012-2020
Ludwig Boltzmann Institute for Digital Health and Prevention
2019
Ludwig Boltzmann Institute for Lung Vascular Research
2019
BackgroundLung eosinophilia is a hallmark of asthma, and eosinophils are believed to play crucial role in the pathogenesis allergic inflammatory diseases. Short-chain fatty acids (SCFAs), such as acetate, propionate, butyrate, produced high amounts gastrointestinal tract by commensal bacteria can be absorbed into bloodstream. Although there recent evidence that SCFAs beneficial asthma models, effect on has remained elusive.ObjectiveThe was investigated human eosinophil function mouse model...
A frequent adverse effect of mutation-specific BRAF inhibitor therapy is the induction epithelial proliferations including cutaneous squamous cell carcinomas. To date, only factor identified contributing to their development activation mitogen-activated signal transduction cascade by mutations in RAS genes. However, these explain 60% tumors; hence, it important identify what causing remaining tumors.
Idiopathic pulmonary fibrosis (IPF) is a disease with high 5-year mortality and few therapeutic options. Prostaglandin (PG) E2 exhibits antifibrotic properties reduced in bronchoalveolar lavage from patients IPF. 15-Prostaglandin dehydrogenase (15-PGDH) the key enzyme PGE2 metabolism under control of TGF-β microRNA 218.We sought to investigate expression 15-PGDH IPF potential specific inhibitor this mouse model human tissue.In vitro studies, including fibrocyte differentiation, regulation...
Disruption of the blood-air barrier, which is formed by lung microvascular endothelial and alveolar epithelial cells, a hallmark acute injury. It was shown that cells release an unidentified soluble factor enhances barrier function cells. In this study we reveal primarily prostaglandin (PG) E2 accounts for barrier-promoting activity. Conditioned media from (primary ATI-like cells) collected BALB/c mice A549 increased electrical resistance pulmonary human respectively. This effect reversed...
Abstract Background Recent studies pointed to a crucial role for apolipoproteins in the pathogenesis of inflammatory diseases. However, apolipoprotein‐IV (ApoA‐IV) allergic inflammation has not been addressed thoroughly thus far. Objective Here, we explored anti‐inflammatory effects and underlying signaling pathways ApoA‐IV on eosinophil effector function vitro vivo. Methods Migratory responsiveness, Ca 2+ ‐flux apoptosis human peripheral blood eosinophils were assessed vitro....
Eosinophils are important multifaceted effector cells involved in allergic inflammation. Following allergen challenge, eosinophils and other immune release secreted phospholipases, generating lysophosphatidylcholines (LPCs). LPCs potent lipid mediators, serum levels of associate with asthma severity, suggesting a regulatory activity development. As yet, the direct effects on remain unclear. In present study, we tested major LPC species (16:0, 18:0 18:1) isolated from healthy human donors....
Pulmonary vascular dysfunction is a key event in acute lung injury. We recently demonstrated that PGE2 , via activation of E-prostanoid (EP)4 receptors, strongly enhances microvascular barrier function vitro. The aim this study was to investigate the beneficial effects concomitant EP4 receptor murine models pulmonary inflammation. inflammation male BALB/c mice induced by LPS (20 μg per mouse intranasally) or oleic acid (0.15 μL·g-1 i.v. ). In-vitro, endothelial determined measuring...
Abstract Prostaglandin (PG) D2 is the ligand for G-protein coupled receptors DP1 (D-type prostanoid receptor 1) and DP2 (also known as chemoattractant homologous molecule, expressed on Th2 cells; CRTH2). Both, are cellular surface of eosinophils; although it has become quite clear that PGD2 induces eosinophil migration mainly via receptors, role in responses remained elusive. In this study, we addressed how signaling complements pro-inflammatory effects DP2. We found prolongs survival...
Endothelial dysfunction is a hallmark of inflammatory conditions. We recently demonstrated that prostaglandin (PG)E2 enhances the resistance pulmonary endothelium in vitro and counteracts lipopolysaccharide (LPS)-induced inflammation vivo via EP4 receptors. The aim this study was to investigate role EP1/EP3 receptor agonist 17-phenyl-trinor-(pt)-PGE2 on acute lung mouse model. In LPS-induced mice, 17-pt-PGE2 reduced neutrophil infiltration inhibited vascular leakage. These effects were...
<b>Background:</b> Recent studies pointed to a crucial role for apolipoproteins in the pathogenesis of inflammatory diseases. However, apolipoprotein-IV (ApoA-IV) allergic inflammation has not been addressed thus far. <b>Objective:</b> Here we explored anti-inflammatory effects and underlying signaling pathways ApoA-IV on eosinophil effector function vitro vivo. <b>Methods:</b> serum levels were determined by ELISA. In assays eosinophil, monocyte macrophage performed. Allergen-driven airway...