A5082461267- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory viral infections research
- Infectious Diseases and Mycology
- Tuberculosis Research and Epidemiology
- Pneumonia and Respiratory Infections
- Infectious Diseases and Tuberculosis
- Sarcoidosis and Beryllium Toxicity Research
- COVID-19 Clinical Research Studies
- Nosocomial Infections in ICU
- Systemic Sclerosis and Related Diseases
- Pleural and Pulmonary Diseases
- Diagnosis and treatment of tuberculosis
- Cystic Fibrosis Research Advances
- Viral Infections and Vectors
- Influenza Virus Research Studies
- Ophthalmology and Visual Impairment Studies
- Parasitic infections in humans and animals
- Facial Trauma and Fracture Management
- Respiratory and Cough-Related Research
- Respiratory Support and Mechanisms
- Renal and related cancers
- Renal cell carcinoma treatment
- Medical and Biological Sciences
Medical University of Graz
2014-2024
Graz University Hospital
2014-2024
Austrian Society of Dermatology and Venereology
2022
University of Graz
2012-2021
German Center for Infection Research
2018
Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde
2014
Charité - Universitätsmedizin Berlin
2007-2009
Schlosspark-Klinik
2007
Humboldt-Universität zu Berlin
2006
Universitäts-Augenklinik Bonn
1958
The present guideline provides a new and updated concept of treatment prevention adult patients with community-acquired pneumonia. It replaces the previous dating from 2009.The was worked out agreed on following standards methodology S3-guideline. This includes systematic literature search grading, structured discussion recommendations supported by as well declaration assessment potential conflicts interests.The has focus specific clinical circumstances, an update severity assessment, for...
Multicenter trials in Southeast Asia have shown better survival rates among patients with severe malaria, particularly those high parasitemia levels, treated intravenous (IV) artesunate than quinine. In Europe, quinine is still the primary treatment for malaria. We conducted a retrospective analysis 25 travelers malaria who returned from malaria-endemic regions and were at 7 centers Europe. All survived. Treatment IV rapidly reduced levels. 6 5 centers, self-limiting episode of unexplained...
Rationale: Invasive pulmonary aspergillosis has been increasingly reported in nonneutropenic patients, including those with underlying respiratory diseases.Objectives: We compared the diagnostic performances of galactomannan, 1,3-β-D-glucan, and Aspergillus-specific lateral-flow device tests that conventional culture by using bronchoalveolar lavage fluid samples from patients diseases.Methods: analyzed 268 221 diseases (and without hematologic malignancy or previous solid organ...
Zusammenfassung Die vorliegende Leitlinie umfasst ein aktualisiertes Konzept der Behandlung und Prävention von erwachsenen Patienten mit ambulant erworbener Pneumonie löst die bisherige aus dem Jahre 2016 ab. Sie wurde entsprechend den Maßgaben zur Methodologie einer S3-Leitlinie erarbeitet verabschiedet. Hierzu gehören eine systematische Literaturrecherche -bewertung, strukturierte Diskussion Literatur begründbaren Empfehlungen sowie Offenlegung Bewertung möglicher Interessenskonflikte....
Rationale: Pulmonary hypertension (PH) is a common, severe comorbidity in interstitial lung diseases such as pulmonary fibrosis (PF), and it has limited treatment options. Excessive vascular inflammation are often present PH, but the underlying mechanisms still not well understood. Objectives: To identify novel functional link between natural killer T (NKT) cell activation PF-PH. Methods: Multicolor flow cytometry, secretome, immunohistological analyses were complemented by pharmacological...
In recent years galactomannan antigen testing (GM) and also Aspergillus PCR have become increasingly important for diagnosis of invasive aspergillosis (IA). Whether or not these tests need to be performed with bronchoalveolar lavage fluid (BALF; i.e., primary site infection), blood samples is sufficient, remains, however, a matter debate. We evaluated the diagnostic performance GM ELISA, by using BALF obtained at same day from total 53 immunocompromised patients (16 probable/proven IA 37 no...
Abstract Introduction The incidence of invasive pulmonary aspergillosis (IPA) in intensive care unit (ICU) patients is increasing, and early diagnosis the disease treatment with antifungal drugs critical for patient survival. Serum biomarker tests IPA typically give false-negative results non-neutropenic patients, galactomannan (GM) detection, preferred diagnostic test using bronchoalveolar lavage (BAL), often not readily available. Novel approaches to detection ICU are needed. In this...
Human toxocariasis is usually contracted by exposure to contaminated soil. This disease rarely transmitted raw meat or giblets of paratenic animals, such as chickens, lambs, cows. We present a case isolated cerebral presumably caused the consumption duck liver. 55-year-old woman had sudden-onset hemiparesis right leg, eosinophilia 30%, and markedly elevated total serum IgE levels. Magnetic resonance imaging demonstrated multiple hyperintense lesions on T2-weighed images. Tests for antibodies...
Summary We evaluated the performance of Aspergillus ‐specific lateral‐flow device ( LFD ) test for diagnosing invasive pulmonary aspergillosis IPA in patients with underlying haematological malignancies. Participating centres were two Austrian University Hospitals Graz and Innsbruck. was 95 bronchoalveolar lavage fluid BALF samples from 72 collected prospectively Graz, 24 bio bank 23 (21 probable Invasive fungal infections classified according to revised European Organization Research...
Idiopathic pulmonary fibrosis (IPF) is a disease with high 5-year mortality and few therapeutic options. Prostaglandin (PG) E2 exhibits antifibrotic properties reduced in bronchoalveolar lavage from patients IPF. 15-Prostaglandin dehydrogenase (15-PGDH) the key enzyme PGE2 metabolism under control of TGF-β microRNA 218.We sought to investigate expression 15-PGDH IPF potential specific inhibitor this mouse model human tissue.In vitro studies, including fibrocyte differentiation, regulation...
Aspergillus spp. have been shown to induce T-helper cell (Th) 1 and Th17 subsets resulting in elevated levels of several cytokines. The objective this study was analyse a bundle cytokines serum bronchoalveolar lavage fluid (BALF) patients with without invasive pulmonary aspergillosis (IPA). This nested case-control analysis included 10 probable/proven IPA 20 matched controls evidence IPA, out pool prospectively enrolled (2014-2017) adult cases underlying haematological malignancies suspected...
Background Although the number of lung transplantations (LTx) performed worldwide for coronavirus disease 2019 (COVID-19)-induced acute respiratory distress syndrome (ARDS) is still low, there general agreement that this treatment can save a subgroup most severely ill patients with irreversible damage. However, true proportion eligible LTx, overall outcome and impact LTx on pandemic are unknown. Methods A retrospective analysis was using nationwide registry hospitalised confirmed severe type...
Background: Diagnosis of chronic pulmonary aspergillosis (CPA) is challenging. Symptoms are unspecific or missing, radiological findings variable and proof mycological evidence limited by the accuracy diagnostic tests. The goal this study was to investigate performance galactomannan (GM), newly formatted Aspergillus-specific lateral-flow-device test (LFD), a number cytokines in bronchoalveolar lavage fluid (BALF) samples obtained from patients with CPA, respiratory disorders without CPA...
Background: Molds and other pathogens induce elevated levels of several cytokines, including interleukin (IL)-6 IL-8. The objective this study was to investigate the prognostic value IL-6 IL-8 as well fungal biomarkers in blood bronchoalveolar lavage fluid (BAL) for overall survival patients with underlying hematological malignancies suspected mold infection. Methods: This cohort included 106 prospectively enrolled adult cases undergoing bronchoscopy. Blood samples were collected within 24...
Summary The coronavirus disease 2019 (COVID-19) pandemic is currently a challenge worldwide. In Austria, crisis within the healthcare system has so far been prevented. treatment of patients with community-acquired pneumonia (CAP), including SARS-CoV‑2 infections, should continue to be based on evidence-based CAP guidelines during pandemic; however, COVID-19 specific adjustments are useful. chronic lung diseases adapted but must still guaranteed.
Chronic pulmonary aspergillosis (CPA) can complicate underlying diseases, and clinical management of CPA is challenging. Guidelines support clinicians but due to the complexity disease they be difficult adhere to.To map current guideline recommendations for into a scoring tool facilitate quantify adherence in practice.Recommendations diagnosis, treatment follow-up presented ESCMID/ERS/ECMM CPAnet guidance documents were assembled weighed on basis their strength recommendation level...