A5100413362- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Sepsis Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Inflammation biomarkers and pathways
- Thermal Regulation in Medicine
- Traditional Chinese Medicine Analysis
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Hemodynamic Monitoring and Therapy
- Obstructive Sleep Apnea Research
- Lung Cancer Research Studies
- Cell death mechanisms and regulation
- Neuroscience of respiration and sleep
- Sarcoma Diagnosis and Treatment
- Erythrocyte Function and Pathophysiology
- Autophagy in Disease and Therapy
- Heme Oxygenase-1 and Carbon Monoxide
- Lung Cancer Treatments and Mutations
- Pleural and Pulmonary Diseases
The First People’s Hospital of Lianyungang
2012-2025
Inner Mongolia People's Hospital
2025
Nanjing Medical University
2015-2024
Beijing Hospital of Traditional Chinese Medicine
2024
Capital Medical University
2024
Lianyungang Oriental Hospital
2020-2024
Xuzhou Medical College
2020-2024
Harbin Medical University
2024
First Affiliated Hospital of Harbin Medical University
2024
Mengchao Hepatobiliary Hospital
2023
As pivotal elements involved in inflammation, inflammasomes represent a group of multiprotein complexes triggering the maturation proinflammatory cytokine interleukin (IL)-1β and IL-18. Although importance inflammatory diseases is well appreciated, precise characterization their expressions lung cancer remains obscure. This study aimed to determine various cell lines tissues understand potential roles cancer. Our findings showed that inflammasome components were markedly upregulated elicited...
Pyroptosis, an inflammatory form of programmed cell death, is the initiating event sepsis and results in immune imbalance by releasing IL‐1 β IL‐18 early stages. Studies show that enhancing autophagy via genetic manipulation can inhibit pyroptosis prolong survival a animal model, indicating possible therapeutic strategy against sepsis. However, almost no study so far has achieved inhibition pharmacological induction disease model. To this end, we established vitro model stimulating primary...
To evaluate the therapeutic efficacy of thrombolysis in patients with pulmonary embolism (PE) and hypertension (PH), identify factors influencing outcomes. A retrospective analysis was conducted on 148 diagnosed PE complicated by PH who received thrombolytic treatment at Tianjin Medical University General Hospital Inner Mongolia People's between January 2022 August 2024. Changes inflammatory markers, blood gas parameters, coagulation function indicators before after were compared, overall...
Fasudil, a selective rho kinase (ROCK) inhibitor, has been reported to play beneficial role in systemic inflammation acute lung injury, but its mechanism for ameliorating pulmonary edema and remains unclear. Using hematoxylin-and-eosin (H&E) staining, immunohistochemistry, enzyme-linked immunosorbent assay, quantitative real time PCR Western blotting, we found that fasudil attenuated LPS-induced decreased edema, suppressed inflammatory responses including leukocyte infiltration IL-6...
Several single-center studies have evaluated the predictive performance of mechanical power (MP) on weaning outcomes in prolonged invasive ventilation (IMV) patients. The relationship between MP and all IMV patients has rarely been studied. A retrospective study was conducted MIMIC-IV with for more than 24 h to investigate correlation outcome using logistic regression model subgroup analysis. discriminative ability MP, normalized dynamic lung compliance (Cdyn-MP) predicted body weight...
To explore the predictive value of new comprehensive respiratory mechanics parameters elastic power (EP) and normalized to compliance (Cst-EP) in evaluation severity 28-day prognosis ARDS patients.The MIMIC-III database was used identify patients under invasive mechanical ventilation for at least 48 h. Their baseline data ventilatory variables were collected. EP, energy, driving pressure calculated according corresponding formulas. assessing evaluated. The correlation between Cst-EP...
The present study aimed to investigate the effects of mechanical stretch and lipopolysaccharides (LPS) on expression transforming growth factor-β1 (TGF-β1) collagen viscoelasticity in human embryonic MRC-5 lung fibroblasts cultured vitro assess mechanisms ARDS-associated ventilator-induced injury using an model. Human were treated with different concentrations LPS establish acute respiratory distress syndrome (ARDS) cell model, followed by further culture under amplitudes Flexcell system a...
Abstract Background Mechanical power (MP) is the total energy released into entire respiratory system per minute which mainly comprises three components: elastic static power, Elastic dynamic and resistive power. However, to overcome resistance gas flow not key factor in causing lung injury, but (EP) generates baseline stretch of fibers overcomes elastance may be closely related ARDS severity. Thus, this study aimed investigate whether EP superior other ventilator variables for predicting...
Sepsis-induced kidney injury (SAKI) has been frequently established as a prevailing complication of sepsis which is linked to unfavorable outcomes. Fatty acid-binding protein-4 (FABP4) proposed possible target for the treatment SAKI. In current work, we aimed explore role and underlying mechanism FABP4 in lipopolysaccharide (LPS)-induced human renal tubular epithelial cell damage. LPS-induced 2 (HK2) cells, expression was tested by reverse transcription-quantitative polymerase chain reaction...
Neonatal sepsis is one of the most prevalent causes death neonates. However, mechanisms underlying neonatal remained unclear. The present study identified a total 1128 upregulated mRNAs and 1008 downregulated mRNAs, 28 lncRNAs, 61 lncRNAs in sepsis. Then, we constructed PPI networks to identify key regulators sepsis, including ITGAM, ITGAX, TLR4, ITGB2, SRC, ELANE, RPLP0, RPS28, RPL26, RPL27. lncRNA coexpression analysis showed HS.294603, LOC391811, C12ORF47, LOC729021, HS.546375, HNRPA1L-2,...
Background. The energy delivered by a ventilator to the respiratory system in one minute is defined as mechanical power (MP). However, effect of ventilator-induced lung injury (VILI) patients suffering from acute distress syndrome (ARDS) still unknown. Our previous studies revealed that CXCL10 may be potential biomarker ARDS. Therefore, aim this study was compare rats and under different MP conditions explore involvement its receptor CXCR3 VILI. Methods. Patients were divided into high group...
Dear Editor: The emergence of multidrug-resistant tuberculosis (MDR-TB) is bringing new challenges. MDR-TB caused by Mycobacterium (M. tuberculosis) that resistant to isoniazid and rifampicin, with or without resistance other anti-tuberculosis drugs. Approximately 450,000 people developed worldwide in 2012 an estimated 170,000 died from the disease[1]. Bacterial burden not strictly correlated disease progression, several hallmarks severe suggest insufficiently controlled inflammation...
Abstract Background Cancer stem cells (CSCs) are regarded as the root of tumor progression, thus representing an anti-cancer therapy through targeting this cell sub-population. Methods Non-small lung cancer (NSCLC) CSCs were enriched by non-adherent spheroid formation analysis. Lentivirus infection was used to stably change gene expression. Cell cycle, EdU incorporation, apoptosis, viability, ALDH1 activity, and in vivo initiation assays performed detect effects Cryptotanshinone (CT), a...
Acute lung injury (ALI) is a respiratory tract disease characterized by increased alveolar/capillary permeability, inflammation and structural damage to tissues, which can progress transform into acute distress syndrome (ARDS). Although there are several treatment strategies available manage this condition, still no specific cure for ALI. Aldo‑keto reductase family 1 member C1 (AKR1C1) of the aldo‑keto superfamily, well‑known Nrf2 target gene an oxidative stress gene. The aim present study...
Objective. To analyze the differentially expressed genes (DEGs) in rats with endogenous acute respiratory distress syndrome (ARDS) lung injury and explore pathogenesis early diagnostic molecular markers using whole transcriptomic data. Methods. Twelve 8-week-old male Sprague Dawley were selected randomly equally divided into ARDS group normal control group. RNA was extracted from left tissues of both groups sequenced paired-end sequencing mode Illumina Hiseq platform. The DEGs miRNA, cirRNA,...
A total of 121 patients with moderate to severe ARDS admitted the intensive care unit (ICU) from June 2017 April 2020 and treated invasive mechanical ventilation were sequentially included in this study. Their general information was collected, MP recorded at 0 h, 24 48 72 h after admission ICU. Professionally trained researchers performed LUS assessments. Patients divided into death survival groups according their 28-day prognosis. The trend four time points analyzed. receiver operating...
Hypercoagulability emerges as a central pathological feature and clinical complication in nephrotic syndrome. Increased platelet activation aggregability are closely related to hypercoagulability Monocyte-platelet aggregates (MPAs) have been proposed represent robust biomarker of activation. The aim this study was investigate levels the circulating MPAs with different monocyte subsets evaluate association
Malignant pleural effusion (MPE) is a complicated condition of patients with advanced tumors. Further dissecting the microenvironment infiltrated immune cells and malignant are warranted to understand immune-evasion mechanisms tumor development progression.