A5049708848- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cancer-related molecular mechanisms research
- Cardiac Arrhythmias and Treatments
- Catalytic C–H Functionalization Methods
- Oxidative Organic Chemistry Reactions
- EEG and Brain-Computer Interfaces
- Context-Aware Activity Recognition Systems
- Atrial Fibrillation Management and Outcomes
- Alkaloids: synthesis and pharmacology
- Cardiac Imaging and Diagnostics
- Gaze Tracking and Assistive Technology
Campbell University
2023
University of Pennsylvania
2019-2023
Temple University
2018
Systemic lupus erythematosus (SLE) is a highly female-biased systemic autoimmune disease, but the molecular basis for this female bias remains incompletely elucidated. B and T lymphocytes from patients with SLE mouse models of exhibit features epigenetic dysregulation on X chromosome which may contribute to strong bias. We therefore examined fidelity dynamic X-chromosome inactivation maintenance (dXCIm) in pathogenesis two murine spontaneous lupus-NZM2328 MRL/lpr-with disparate levels...
In females, the long noncoding RNA Xist drives X-chromosome Inactivation (XCI) to equalize X-linked gene dosage between sexes. Unlike other somatic cells, dynamic regulation of and heterochromatin marks on inactive X (Xi) in female lymphocytes results biallelic expression some genes, including Tlr7, Cxcr3, Cd40l, implicated sex-biased autoimmune diseases. We now find that while is dispersed across nucleus NK cells dendritic (DCs) partially co-localizes with H3K27me3 bone marrow-derived...
Herein, we report a simplified approach to the synthesis of medium-ring ethers through electrophilic activation secondary alcohols with (poly)cationic λ
To evaluate the bleeding risk associated with anticoagulation (AC) in kidney transplant patients post-operative atrial fibrillation (AF). We conducted a retrospective analysis of all adult recipients performed from October 2012 to February 2019 at our institution, University North Carolina Chapel Hill, which accounted for 428 transplants. Variables assessed included AF occurrence, AC use, complications, stroke and stratification (determined using...