To further understand the effect of refractive error on corneal dimensions and function.Corneal curvature, thickness, axial length measurements were performed, as well specular microscopy fluorophotometry, patients with various statuses. 216 subjects, mean age 22.2 (SD 4.2) years, examined. Patients previous contact lens wear history, external eye diseases, ocular surgeries, excluded.The corneas flatter in eyes longer (r = -0.22, p 0.003). Eyes more myopic spherical equivalent had -0.90,...

PURPOSE: To evaluate the predictability of intraocular lens (IOL) power calculations using IOLMaster (Carl Zeiss) and different IOL calculation formulas in eyes with a long axial length (AL). SETTING: Department Ophthalmology, Far Eastern Memorial Hospital, Taipei, Taiwan. METHODS: This study included 68 an AL longer than 25.0 mm that had phacoemulsification implantation. Preoperative keratometric index measurements were obtained (Group 1) or, respectively, applanation ultrasound automatic...

<h3>Background/aims</h3> The authors estimated the association between corneal biomechanical properties and axial length in myopic children verified relationship intraocular pressure (IOP). <h3>Methods</h3> This cross-sectional study included 126 eyes of 63 children, aged 12.02±3.19 years. Corneal hysteresis (CH), resistance factor (CRF), central thickness (CCT) IOP were recorded with Reichert Ocular Response Analyzer. Axial (AL) anterior chamber depth (ACD) measured by IOLMaster, whereas...

: To investigate the predictability of intraocular lens (IOL) power calculation using IOLMaster and different IOL formulas in eyes with various axial length (AL).: Patients were included who underwent uneventful phacoemulsification implantation Department Ophthalmology, Far Eastern Memorial Hospital, Taipei, Taiwan, China from February 2007 to January 2009. Preoperative AL keratometric values (Ks) measured by optical biometry. divided into 3 groups based on less than 22mm (Group 1), 22-26mm...

To determine the effect of mitomycin-C (MMC) on cornea after a single intraoperative application.Department Ophthalmology, Far Eastern Memorial Hospital, Ban-Chiao, Taipei, Taiwan.Mechanical epithelium debridement central 10.0 mm was performed in 63 pigmented rabbits. One group corneas (MMC1, n = 42) soaked with MMC 0.01% solution for 2 minutes; second (MMC2, 0.02% minutes. Control (n were balanced salt Changes corneal thickness, clarity, epithelial defect size, endothelial cell density, and...

To compare anterior chamber depth (ACD) measurements using two non-contact optical devices, Pentacam and IOLMaster, a contact device, ultrasonic A-scan in phakic pseudophakic eyes.Ninety 94 eyes were enrolled this prospective study. The difference between ACD by the three devices was analyzed repeated-measures analysis of variance, agreement among investigated. accuracy detecting lens surface intraocular (IOL) with or without blue-blocker also assessed.In eyes, measured deepest smallest...

BackgroundThe aim of this study was to investigate the therapeutic role preservative‐free artificial tears containing hyaluronic acid and high potassium ion concentration (HA/high‐K tears) on mechanically scraped or alkali‐induced corneal epithelial defects in rats.MethodsWe created corneas 24 Sprague‐Dawley (SD) rats (three groups eight rats) 27 SD nine rats). Then we applied topical 0.3 per cent 0.15 HA/high‐K four times daily for 1.5 days compared its effect with that phosphate buffered...

To investigate the expression of chemokines and their signaling pathways after application mitomycin C (MMC) to corneal fibroblasts.Primary porcine human fibroblasts from passages 3 6 were treated with MMC at concentrations 0.05, 0.1, or 0.2 mg/mL for 1, 2, 5, 10 minutes. The relative interleukin-8 (IL-8) monocyte chemoattractant protein-1 (MCP-1) investigated reverse transcription, quantitative real-time polymerase chain reaction (qRT-PCR), enzyme-linked immunosorbent assay (ELISA). effects...

Purpose. This study aimed to determine the dynamic changes of NF- κ B-related microRNAs (miRNAs) and cytokines over course experimental autoimmune anterior uveitis (EAAU) elucidate possible immunopathogenesis. Materials Methods. Uveitis was induced in Lewis rats using bovine melanin-associated antigen. The inflammatory activity chamber clinically scored, leukocytes aqueous humor were quantified. RNA extracted from iris/ciliary bodies popliteal lymph nodes reveal eight target miRNAs...

Purpose: We investigated whether methylprednisolone (MP) treatment halting retinal ganglion cell (RGC) death and having anti-inflammatory effect over a narrow therapeutic window affects the integrity of blood-optic nerve barrier (BOB) in rat model ischemic optic neuropathy (rAION). Methods: The (ON) vascular permeability was determined by Evans blue extravasation. Changes levels TNF-α IL-1β cytokines were analyzed using quantitative RT-PCR (qRT-PCR) from day 1 to 5 post-rAION. Rats treated...

To investigate the characteristics of subjective symptoms and objective parameters among young patients with dry eye disease (DED) compare them those older patients. We retrospectively enrolled 675 DED who were divided into three age groups (20–41 years [younger], 41–60 [middle], >60 [older]) (n = 143, 304, 228, respectively). Subjective evaluated using Standardized Patient Evaluation Eye Dryness (SPEED) Ocular Surface Disease Index (OSDI) questionnaires. Aqueous tear secretion was Schirmer...

To investigate the concordance between Asia Dry Eye Society (ADES) diagnostic criteria and real-world hospital-based practice, to analyze clinical characteristics of patients with dry eye disease (DED), in Taiwan. Noninterventional, cross-sectional, retrospective study. Data were analyzed for adults newly diagnosed DED from three tertiary hospitals. The primary endpoint was proportion who fulfilled ADES DED. Other outcomes classification severity, tear breakup time (TBUT), Schirmer's test,...

Objectives: We aimed to investigate dry eye parameters as potential predisposing factors and estimate the prevalence of high-frequency topical drop usage. Methods: A total 5594 patients treated between November 2015 June 2022 were included. High users (n = 180) those who applied at least one artificial tear per hour, whereas used tears fewer than four times daily classified low 5414). Differences in self-reported symptoms (OSDI, SPEED questionnaires) tear-related parameters, including...

Objective: To correlate corneal light scattering with keratocyte and extracellular matrix reformation after laser in situ keratomileusis (LASIK) photorefractive keratectomy (PRK). Setting: Wilmer Ophthalmological Institute, Johns Hopkins University, Baltimore, Maryland, USA. Methods: Sixteen pigmented rabbit eyes were randomly divided Into 2 groups. Group 1 (n=8) had a 5.0 mm, -10.0 diopter (D) LASIK treatment (n=8), 6.0 D surface PRK mechanical epithelial debridement. The stromal exposed at...

Corneal epithelial permeability studies using fluorophotometers were performed on 90 eyes of 51 normal subjects. After recording the autofluorescence cornea (AFC) and lens (AFL), we applied 20 microliters 2% sodium fluorescein to conjunctival sac. The corneal fluorescence 45 min later (F45), which paralleled fluorescein, was measured by fluorophotometer analyzed. All parameters two each subject correlated well with other. There positive correlation between AFL patient age AFC (r = 0.78, p <...

To determine the effect of cycloplegia on corneal thickness, curvature, anterior chamber depth (ACD), angle-to-angle (ATA) and white-to-white (WTW) distances, axial length (AL).Changes in ACD, ATA WTW AL with without were analyzed 31 eyes young myopic adults, aged 26.4 ± 3.0 years. Pentacam was used to measure volume, curvatures. Visante optical coherent tomography (OCT) measured distance, pupil size. The distance using IOLMaster.Cycloplegia induced significant flattening curvatures (p =...

<h3>Aim</h3> To determine if residual cylindrical refractive error after cataract surgery can be adjusted using the light-adjustable lens (LAL). <h3>Methods</h3> The LAL is a photosensitive silicone intraocular whose power post-operatively UV light at 365 nm. A digital delivery device (DLD) used to adjust in situ correct errors non-invasively. Profiles developed and spherical were tested on five patients, with postoperative toric of 1.25–1.75 D. At 2 weeks post-implantation, best corrected...