A5046422215- Microbial infections and disease research
- Epilepsy research and treatment
- Mycobacterium research and diagnosis
- Animal Behavior and Welfare Studies
- Neuroscience and Neuropharmacology Research
- Kruppel-like factors research
- Innovations in Aquaponics and Hydroponics Systems
- Neurological diseases and metabolism
- Skin and Cellular Biology Research
- Clostridium difficile and Clostridium perfringens research
- Genetic Syndromes and Imprinting
- Veterinary Pharmacology and Anesthesia
- Diet and metabolism studies
- Vector-Borne Animal Diseases
- Pharmaceutical and Antibiotic Environmental Impacts
- Gut microbiota and health
- Pharmacological Effects and Toxicity Studies
- Effects of Environmental Stressors on Livestock
- Metabolism and Genetic Disorders
- Bacterial Infections and Vaccines
University of Turin
2020-2025
Sepsis, a dysregulated host response to infection, severely affects calf health. To date, sepsis diagnosis relies on clinical examination and positive blood culture. Differently, in humans 16S rRNA gene analysis is valuable adjunct culture as it allows for broader assessment of bacterial DNA whole its fractions. However, efficacy cattle remains unknown. Therefore, this study characterized compared the detected fractions between healthy calves those showing signs sepsis. The sample was 18...
Abstract Neurofilament light chain (Nf-L) is a biomarker for axonal damage in human neurology but understudied cattle. With this study we wanted to determine Nf-L stability at two different storage temperatures and levels healthy cattle the relationship with age, evaluate whether holds diagnostic potential neurological disorders, an association exists between serum cerebrospinal fluid (CSF). To do this, measured CSF samples from 49 75 sick Storage −80 °C or −20 had no impact on...
Central nervous system (CNS) infections in cattle are a major cause of economic loss and mortality. Machine learning (ML) techniques gaining widespread application solving predictive tasks both human veterinary medicine.Our primary aim was to develop compare ML models that could predict the likelihood CNS disorder infectious or inflammatory origin neurologically-impaired cattle. Our secondary create user-friendly web based on model for diagnosis infection inflammation CNS.Ninety-eight with...
Status epileptics (SE) and cluster seizures (CS) are serious neurological emergencies associated with poor outcome in epileptic patients. Data on risk factors patients affected by CS SE have not been studied extensively to date. In the present retrospective study potential predictive of negative a population dogs were analyzed. Ninety-three included study: 21/93 (23%) presented 72/93 (77%) CS. Based multivariate statistical analysis, statistically occurrence first seizure outside defined...
Cluster seizures (CS) and status epilepticus (SE) in dogs are severe neurological emergencies that require immediate treatment. Practical guidelines call for constant rate infusion (CRI) of benzodiazepines or propofol (PPF) patients with not responding to first-line treatment, but date only few studies have investigated the use CRI epilepsy.Retrospective clinical study.Dogs received diazepam (DZP) PPF antiepileptic treatment during hospitalization at Veterinary Teaching Hospital University...
Introduction Constant rate infusion (CRI) of benzodiazepines or propofol (PPF) is a therapeutic option for cluster seizures (CS) and status epilepticus (SE) in canine patients non-responding to first-line non-anesthetics. However, specific indications optimal duration CRI are lacking. The aim this study was determine the effect anesthetic on outcome length hospital stay dogs with refractory seizure activity different etiology. Study design Open-label non-randomized clinical trial. Materials...
Introduction Bacterial infection of the central nervous system (CNS) poses a clinical challenge and is leading cause neurological disorders in cattle. Human studies have demonstrated an increase cerebrospinal fluid (CSF) L-lactate levels bacterial meningitis. The aims this study were to establish Reference Interval (RI) for bovine CSF assess its potential as biomarker detecting infectious-inflammatory disorders. Methods was measured field using commercially available lactate monitor. RI...
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<title>Abstract</title> Neurofilament light chain (Nf-L) is a biomarker for axonal damage in human neurology but understudied cattle. With this study we wanted to determine Nf-L stability at two different storage temperatures and levels healthy cattle the relationship with age, evaluate whether holds diagnostic potential neurological disorders, an association exists between serum cerebrospinal fluid (CSF). To do this, measured CSF samples from 49 75 sick Storage -80°C or -20°C had no impact...
Bacterial infection of the central nervous system (CNS) in cattle requires prompt and adequate antimicrobial treatment. The current gold standard for antemortem etiological diagnosis is cerebrospinal fluid (CSF) culture, which often yields false negative results. CSF has long been considered a sterile district healthy patients, but this notion recently challenged. For pilot study, we used 16S rRNA gene sequencing to investigate microbial composition presenting with CNS disorders compare it...