A5091168846- Vasculitis and related conditions
- Cancer Immunotherapy and Biomarkers
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Systemic Lupus Erythematosus Research
- Otitis Media and Relapsing Polychondritis
- Chronic Lymphocytic Leukemia Research
- Rheumatoid Arthritis Research and Therapies
- Renal Diseases and Glomerulopathies
- Autoimmune and Inflammatory Disorders Research
- Urticaria and Related Conditions
- Colorectal Cancer Treatments and Studies
- Immunodeficiency and Autoimmune Disorders
- Systemic Sclerosis and Related Diseases
- Melanoma and MAPK Pathways
- Sarcoidosis and Beryllium Toxicity Research
- Hepatitis C virus research
- Parvovirus B19 Infection Studies
- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- Inflammatory Myopathies and Dermatomyositis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- IgG4-Related and Inflammatory Diseases
- Neurological Complications and Syndromes
- Atherosclerosis and Cardiovascular Diseases
- Osteomyelitis and Bone Disorders Research
University of Calgary
2011-2024
Mount Sinai Hospital
2015-2021
University of Toronto
2015-2021
McGill University
2018-2019
Western University
2018
Canadian Arthritis Patient Alliance
2018
University of British Columbia
2018
University of Alberta
2018
Canadian Agency for Drugs and Technologies in Health
2018
Université de Montréal
2018
Rapidly progressive glomerulonephritis (RPGN) represents a severe manifestation of anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV), and is with substantial morbidity mortality1. Kidney function following six months therapy predictive future requirement kidney replacement (KRT), patients who require KRT have the worst long-term outcomes1. Therefore, maximal recovery imperative to improve survival quality life.
To develop recommendations for the assessment of people with systemic lupus erythematosus (SLE) in Canada. Recommendations were developed using GRADE (Grading Assessment, Development, and Evaluation) approach. The Canadian SLE Working Group (panel rheumatologists a patient representative from Arthritis Patient Alliance) was created. Questions recommendation development identified based on results previous survey practice patterns members Rheumatology Association. Systematic literature...
ANCA-associated vasculitis (AAV) can affect all age groups. We aimed to show that differences in disease presentation and 6 month outcome between younger- older-onset patients are still incompletely understood.
VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic; OMIM #301054) syndrome is an autoinflammatory condition first described in November 2020.<sup>1</sup> It characterized by vacuoles myeloid and erythroid precursor cells on bone marrow biopsy caused a monogenic somatic mutation the ubiquitin-like modifier activating enzyme 1 (<i>UBA1</i>) gene.<sup>1,2</sup>
Objective Patient-initiated follow-up (PIFU) for rheumatoid arthritis (RA) is a model of care delivery wherein patients contact the clinic when needed instead having regularly scheduled follow-up. Our objective was to investigate influence different patient eligibility characteristics on number potentially deferred visits inform future implementation PIFU strategy. Methods We conducted retrospective chart review 7 rheumatologists' practices at 2 university-based clinics between March 1,...
Objective To conduct an environmental scan and appraisal of online patient resources to support rheumatoid arthritis (RA) flare self-management. Methods We used the Google search engine (last March 2023) using terms "rheumatoid arthritis" "flare management." Additional searches targeted major organizations, as well regional, national, international resources. Appraisal was conducted by 2 research team members 1 partner assess understandability actionability resource Patient Education...
Takayasu arteritis (TAK) is a large vessel vasculitis that predominately affects young women and can cause severe ischemic complications. Given the rarity of TAK, management this condition challenging. We aim to describe current rheumatologist practices for TAK identify discrepancies gaps in knowledge.An online survey (developed by Canadian Vasculitis Network approved Rheumatology Association) containing 48 questions with regard diagnosis, monitoring treatment was distributed 495 adult...
Objectives : To study variations in Canadian clinical practice patterns for the management of ANCA-associated vasculitis (AAV) and identify points to consider development national recommendations.
A 69-year-old female with antisynthetase syndrome, a history of multiple recurrent infections, and documented previous negative titres for anti-neutrophil cystoplasmic antibody (ANCA) suddenly developed de novo MPO-ANCA-associated glomerulonephritis three weeks after fecal microbiota transplantation (FMT) Clostridium difficile infections. Six months following her FMT less than two treatment urosepsis, she severe cholestasis, markedly elevated ferritin hypertriglyceridemia. An initial liver...
Hemophagocytic lymphohistiocytosis (HLH) is a severe clinical entity associated with high mortality in the adult population. HLH has been infections, malignancy and autoimmune conditions such as Systemic Lupus Erythematosus (SLE), however this often context of disease flare. Currently, there are limited reports inaugural SLE manifesting lack consensus on treatment management these patients.Here, we present two rare case cutaneous manifestation lupus HLH. Both patients presented sinister...
Background: Immune checkpoint inhibitors (ICI) have revolutionized cancer therapy by harnessing the immune system to fight cancer. As indications for ICI continue expand, their success in advanced stage malignancies is tempered development of autoimmune toxicities, referred as immune-related adverse events (irAE). Rheumatic irAE (Rh-irAE), particularly arthralgias and arthritis are common optimal management remains unknown. Objectives: The Canadian Research Group Rheumatology Immuno-Oncology...