A5102051248- Prostate Cancer Treatment and Research
- Renal cell carcinoma treatment
- Cancer-related molecular mechanisms research
- Renal and related cancers
- Cancer-related gene regulation
- Bladder and Urothelial Cancer Treatments
- Ubiquitin and proteasome pathways
- Phagocytosis and Immune Regulation
- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- Microtubule and mitosis dynamics
- Pancreatic and Hepatic Oncology Research
- Hippo pathway signaling and YAP/TAZ
- Therapeutic Uses of Natural Elements
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Pediatric Urology and Nephrology Studies
- Circular RNAs in diseases
- Wnt/β-catenin signaling in development and cancer
- Kidney Stones and Urolithiasis Treatments
- Porphyrin Metabolism and Disorders
- Adipose Tissue and Metabolism
- Lung Cancer Diagnosis and Treatment
- Medical and Biological Ozone Research
- Autophagy in Disease and Therapy
Tianjin Medical University
2017-2025
Second Hospital of Tianjin Medical University
2017-2025
Jiuquan Iron & Steel (China)
2025
Duke University
2025
Changhai Hospital
2021-2023
Second Military Medical University
2021-2023
Shandong Tumor Hospital
2010
Shandong First Medical University
2010
In PTEN-deficient prostate cancers, AKT signaling may be activated upon suppression of androgen receptor signaling. Activation as well NF-κB involves a key regulatory protein complex containing PHLPP, FKBP51 and IKKα. Here, we report critical role lncRNA PCAT1 in regulating the PHLPP/FKBP51/IKKα progression castration-resistant cancer (CRPC). Using database queries, bioinformatic analyses, RIP RNA pull-down assays, discovered validated that lncRNA-PCAT1 perturbs activates Expression is...
Abstract Background Cancer-associated fibroblasts (CAFs) are an important part of the tumour microenvironment, and their functions great concern. This series experiments aimed to explore how Yes-associated protein 1 (YAP1) regulates function stromal cells normal (NFs) convert into CAFs in prostate cancer (PCa). Methods The effects conditioned media from different on proliferation invasion epithelial TrampC1 were examined. We then analysed interaction between YAP1/TEAD1 complex SRC, as well...
Metastatic castration-resistant prostate cancer (mCRPC) is one of the main contributors to death patients. To date, detailed molecular mechanisms underlying mCRPC are unclear. Given crucial role epithelial–mesenchymal transition (EMT) in metastasis, we aimed analyse expression and function Transforming growth factor-beta (TGF-β) signal-associated protein named Sox5 mCRPC. The levels were analysed by western blot, immunohistochemistry immunofluorescence. Luciferase reporter assays chromatin...
Objective . To investigate the expression of kinesin family member 20A (KIF20A) in bladder cancer, effect KIF20A on proliferation and metastasis cancer cells, prognosis patients. Methods Bladder tissue its adjacent tissues were collected from tumour The mRNA protein levels samples detected by qRT-PCR western blot. Immunohistochemical (IHC) staining was used to identify distribution proteins samples. relationship between clinical pathology analysed. differential patients with analysed TCGA...
The independent prognostic role of squamous differentiation in pT1 bladder urothelial carcinoma has not been reported previous studies. This article describes the impact on tumor recurrence and survival, whether this histologic variant could indeed alter definitive treatment, based single center-based retrospective data.Totally, we retrieved (1)1449 histologically confirmed patients without variants; (2)227 with our institution, from May 2004 to Oct 2015. total amount high/low grade was...
Abstract Castration-resistant prostate cancer (CRPC) is a highly malignant type of advanced resistant to androgen deprivation therapy. One the important mechanisms for development CRPC persistent imbalanced regulation AR and splice variants (AR/AR-Vs). In this study, we reported KDM4A-AS1, recently discovered lncRNA, as tumor promoter that was significantly increased in cell lines tissues. Depletion KDM4A-AS1 reduced viability, proliferation, migration vitro, growth vivo. We found by binding...
Abstract Background Klotho is a type I transmembrane protein known for its anti‐aging, anti‐inflammatory, antioxidative, and cognitive‐enhancing properties. It also exhibits protective effects against systemic lupus erythematosus, sclerosis, other diseases. The aim of this study was to investigate the relationship between serum levels risk rheumatoid arthritis (RA). Methods Participants from National Health Nutrition Examination Survey (NHANES) conducted 2007 2016 were included. Data on RA...
Enzalutamide, a second-generation androgen receptor (AR) antagonist, has represented the association with improved overall survival in men prostate cancer (PCa). However, PCa patients receiving enzalutamide will eventually develop resistance through various mechanisms without effective regimens. Here, we observed higher level of formin-like 2 (FMNL2) enzalutamide-resistant cells. Functionally, FMNL2 knockdown partially re-sensitized Mechanistically, directly interacted SRC kinase FMNL2-FH1...
Purine metabolism is a promising therapeutic target in cancer; however how cancer cells respond to purine shortage,particularly their adaptation and vulnerabilities, remains unclear. Using the recently developed shortage-inducing prodrug DRP-104 genetic approaches, we investigated these responses prostate, lung glioma models. We demonstrate that when de novo biosynthesis compromised, employ microtubules assemble purinosomes, multi-protein complexes of enzymes enhance efficiency. While this...
Objective: To explore the theraputic effects and potential mechanisms of hydrogen-rich water (HRW) against oxalate-induced kidney injury. Methods: The mouse model Calcium oxalate (CaOx) crystallization was established by feeding a soluble diet. Crystal deposition, tubular injury, fibrosis reactive oxygen species (ROS) production in kidneys were examined histology. Serum indexes renal inflammation oxidative stress detected commercial kits. RNA sequencing (RNA-seq) performed to screen pathways...
As deregulation of androgen receptor (AR) signaling target genes is associated with tumorigenesis and the development prostate cancer (PCa), AR primary therapeutic for PCa. Although patients initially responses to first-line deprivation therapies (ADTs), most them advanced PCa progress lethal castration-resistant (CRPC). Recent studies have suggested molecular mechanisms by which elicit robust up-regulation FKBP51 gene. We suggest that restored expression gene, modulated splicing variant 7...
Abstract Enabled resistance or innate insensitiveness to antiandrogen are lethal for castration-resistant prostate cancer (CRPC). Unfortunately, there seems be little can done overcome the because of largely unknown mechanisms. In prospective cohort study, we found that HOXB3 protein level was an independent risk factor PSA progression and death in patients with metastatic CRPC. vivo, upregulated contributed CRPC xenografts abiraterone resistance. To uncover mechanism driving tumor...
BACKGROUND Kid (kinesin-like DNA binding protein), a member of microtubule-dependent molecular motor proteins, also known as KIF22, is reported to be associated with carcinogenesis and cancer progression in different types malignant tumor, but the biologic behavior clinical outcome KIF22 prostate (PCa) has not been well studied. This study aimed analyze association between PCa patients. MATERIAL AND METHODS The expression tumor specimens compared paired paracancerous tissue from 114 patients...
The optimized concurrent chemoradiotherapy has not been established for patients with advanced esophageal squamous cell carcinoma (SCC). aim of the present study was to evaluate safety and efficacy chemotherapy selective lymph node (SLN) late course accelerated hyperfractionated (LCAF) intensity modulated radiotherapy (IMRT) thoracic SCC. Twelve T3-4N0-1M0-1a SCC were included. total dose SLN LCAF IMRT 59.6 Gy/34 fractions in 5.4 weeks. protocol as following: cisplatin 10 mg/m2 on days 1–5...
Rationale: Thyroid carcinoma-like tumor of the kidney (TLFCK) is an extremely rare variant renal cell carcinoma. Most cases were incidentally found, while we report first case TLFCK presented with hypertension. Patient concerns: A 25-year-old woman was admitted to our hospital presenting hypertension for ∼20 months, without gross hematuria, weight loss, and flank pain. Diagnoses: Imaging studies revealed a right mass multiple calcifications. Histologically, had striking follicles dense,...
The prognostic role of squamous differentiation in upper urinary tract urothelial carcinoma (UTUC) is still unclear. This article describes the impact on prognosis and intravesical recurrence patients with primary UTUC treated radical nephroureterectomy (RNU).Totally, we retrieved (I) 669 histologically confirmed without histologic variants; (II) 101 our institution, dating from April 2003 to 2016. clinical pathological characteristics survival outcomes were compared between these two...
Introduction: Fu-Fang-Jin-Qian-Cao is a Chinese herbal preparation used to treat urinary calculi. can protect renal tubular epithelial cells from calcium oxalateinduced injury by inhibiting ROS-mediated autopathy. The mechanism still needs further exploration. Metabonomics new subject; the combination of metabolomics and network pharmacology find pathways for drugs act on targets more efficiently. Methods: Comprehensive study autophagy in oxalate-induced injury. Based UHPLC-Q-TOF-MS,...
Rationale: Extramedullary plasmacytoma (EMP) a rare plasma cell disorder and is frequently associated with bone marrow infiltration. Most EMPs involve mucosal lymphoid tissue, especially in the nasopharyngeal area, respiratory tract, head neck region. Primary involvement of kidney exceedingly rare. Patient Concerns: A 14-year-old girl was admitted our hospital intermittent right upper quadrant pain for 1 month recent (1 day) progressive deterioration. There mass found by ultrasonography...
We aimed to determine whether intronic circRNA acts as a molecular sponge in castration-resistant prostate cancer (CRPC).
Immunohistochemistry (IHC) analysis of primary tumors revealed that AXL expression is associated with survival in patients different cancers. The objective our study to investigate the relationship between and clinical outcomes bladder carcinoma (BC).A total 407 samples from Cancer Genome Atlas (TCGA) database 203 pathological diagnosis BC hospital were used assess association patients. IHC was performed evaluate tumor tissue collected after surgical treatment.Data TCGA showed mRNA...
Abstract Background Kidney stones are common, frequently occurring worldwide. Some studies have analysed the relationship between dyslipidaemia and kidney stone occurrence but produced inconsistent results due to shortcomings such as small sample sizes, sampling bias, limited data acquisition. Therefore, correlation with sufficient sources, wide coverage, strong representation must be carried out. Methods Samples used in our study were obtained from National Health Nutrition Examination...