A5038341249- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Stroke Rehabilitation and Recovery
- Intracerebral and Subarachnoid Hemorrhage Research
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Peripheral Artery Disease Management
- Lipoproteins and Cardiovascular Health
- Cerebrovascular and genetic disorders
- Neurological Disorders and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Alzheimer's disease research and treatments
- Blood Pressure and Hypertension Studies
- Neurosurgical Procedures and Complications
- Cardiovascular Health and Disease Prevention
- Cardiac Arrhythmias and Treatments
- Cardiac Imaging and Diagnostics
- Moyamoya disease diagnosis and treatment
- Inflammatory mediators and NSAID effects
- Clinical practice guidelines implementation
- Cardiovascular Health and Risk Factors
- Cardiovascular and Diving-Related Complications
Hartford Hospital
2017-2025
Hartford Financial Services (United States)
2017-2025
University of Connecticut
2017-2022
Marks and Spencer (United Kingdom)
2002-2020
University of Hartford
2020
Clinical Research Institute
1999-2019
Janssen Scientific Affairs (United States)
2018-2019
Janssen (United States)
2018-2019
St George's, University of London
2006-2018
Southwestern Medical Center
2010-2017
Apolipoprotein E, type ϵ4 allele (APOE ϵ4), is associated with late-onset familial Alzheimer9s disease (AD). There high avidity and specific binding of amyloid β-peptide the protein ApoE. To test hypothesis that AD may represent clustering sporadic in families large enough to be studied, we extended analyses APOE alleles several series patients. significantly a probable patients (0.36 ± 0.042, AD, versus 0.16 0.027, controls [allele frequency estimate standard error], <i>p</i> = 0.00031)....
Purpose— Our goal is to provide an overview of the current evidence about components evaluation and treatment adults with acute ischemic stroke. The intended audience physicians other emergency healthcare providers who treat patients within first 48 hours after In addition, information for policy makers included. Methods— Members panel were appointed by American Heart Association Stroke Council’s Scientific Statement Oversight Committee represented different areas expertise. reviewed...
The aim of this new statement is to provide comprehensive and timely evidence-based recommendations on the prevention ischemic stroke among survivors or transient attack. Evidence-based are included for control risk factors, interventional approaches atherosclerotic disease, antithrombotic treatments cardioembolism, use antiplatelet agents noncardioembolic stroke. Further provided recurrent in a variety other specific circumstances, including arterial dissections; patent foramen ovale;...
This guideline provides an overview of the evidence on various established and potential stroke risk factors recommendations for reduction risk.Writing group members were nominated by committee chair basis each writer's previous work in relevant topic areas approved American Heart Association Stroke Council's Scientific Statement Oversight Committee. The writers used systematic literature reviews (covering time period since last review published 2001 up to January 2005), reference previously...
Abstract An open angiography‐based, dose rate escalation study on the effect of intravenous infusion recombinant tissue plasminogen activator(rt‐PA) cerebral arterial recanalization in patients with acute focal ischemia was performed at 16 centers. Arterial occlusions consistent carotid or vertebrobasilar territory absence detectable intracerebal hemorrhage were prerequisites for treatment. After 60‐minute rt‐PA infusion, perfusion assesed by repeat angiography and computed tomography scans...
Purpose— Our goal is to provide an overview of the current evidence about components evaluation and treatment adults with acute ischemic stroke. The intended audience physicians other emergency healthcare providers who treat patients within first 48 hours after In addition, information for policy makers included. Methods— Members panel were appointed by American Heart Association Stroke Council’s Scientific Statement Oversight Committee represented different areas expertise. reviewed...
Clinicians and trialists have difficulty with identifying which patients are highest risk for cardiovascular events. Prior ischemic events, polyvascular disease, diabetes mellitus all been identified as predictors of but their comparative contributions to future remain unclear.To categorize the events in stable outpatients various initial manifestations atherothrombosis using simple clinical descriptors.Outpatients coronary artery cerebrovascular or peripheral arterial disease multiple...
Patient delay in seeking treatment for acute coronary syndrome and stroke symptoms is the major factor limiting delivery of definitive these conditions. Despite decades research public education campaigns aimed at decreasing patient times, most patients still do not seek a timely manner. In this scientific statement, we summarize evidence that (1) demonstrates benefits early treatment, (2) describes extent problem delay, (3) identifies factors related to (4) reveals inadequacies our current...
To develop recommendations for the establishment of comprehensive stroke centers capable delivering full spectrum care to seriously ill patients with and cerebrovascular disease. Recommendations were developed by members Brain Attack Coalition (BAC), which is a multidisciplinary group from major professional organizations involved disease.A literature search was conducted 1966 through December 2004 using Medline Pub Med. Articles information about clinical trials, meta-analyses, guidelines,...
The aim of this new statement is to provide comprehensive and timely evidence-based recommendations on the prevention ischemic stroke among survivors or transient attack. Evidence-based are included for control risk factors, interventional approaches atherosclerotic disease, antithrombotic treatments cardioembolism, use antiplatelet agents noncardioembolic stroke. Further provided recurrent in a variety other specific circumstances, including arterial dissections; patent foramen ovale;...
To determine 3-year event rates in outpatients with vascular disease enrolled the REduction of Atherothrombosis for Continued Health (REACH) Registry. REACH 67 888 atherothrombosis [established coronary artery (CAD), cerebrovascular disease, or peripheral arterial (PAD)], at least three atherothrombotic risk factors, from 44 countries. Among 55 499 patients baseline symptomatic 39 675 were eligible follow-up, and 32 247 had data available (81% retention rate). 3 years, 92% taking an...
53 Background: Carotid artery stenosis (CAS) is a common etiology for ischemic stroke. While carotid endarterectomy (CEA) safe and effective treatment CAS, endovascular therapy using stenting may be reasonable alternative. This multicenter study was designed to determine if equivalent CEA in patients with symptomatic CAS. Methods: Patients CAS of 60–99% by cerebral angiogram were prospectively randomized or stenting. All enrolled reviewed multidisciplinary team that included neurologists,...
Several emerging stroke therapies require patients to be treated within several hours of symptom onset. Past studies have documented a significant delay between onset and hospital presentation. As part an experimental treatment study using tissue-type plasminogen activator, we began multifaceted program public professional education reduce the in presentation referral acute patients. The educational efforts focused on improving recognition symptoms, enrollment criteria, need for rapid This...
The burden of cardiovascular disease (CVD) among patients with diabetes is substantial. Individuals are at two- to fourfold increased risk events compared age- and sex-matched individuals without diabetes. In diabetic over the age 65 years, 68% deaths from coronary heart (CHD) 16% stroke (1). A number mechanisms for have been proposed, including tendency toward intracoronary thrombus formation (2), platelet reactivity (3), worsened endothelial dysfunction (4). The mortality in has led...