A5028442515- Sarcoma Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- Urinary and Genital Oncology Studies
- Tunneling and Rock Mechanics
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Bone Tumor Diagnosis and Treatments
- Pancreatic and Hepatic Oncology Research
- Drilling and Well Engineering
- Geotechnical and Geomechanical Engineering
- Cancer, Hypoxia, and Metabolism
- Vascular Tumors and Angiosarcomas
- Orthopedic Infections and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Orthopaedic implants and arthroplasty
- Lung Cancer Research Studies
- Engineering Structural Analysis Methods
- Rock Mechanics and Modeling
- Cancer therapeutics and mechanisms
- Immune cells in cancer
- Inflammatory Biomarkers in Disease Prognosis
- Offshore Engineering and Technologies
- Eosinophilic Disorders and Syndromes
University of Florence
2023-2025
Azienda Ospedaliero-Universitaria Careggi
2022-2024
Reconstruction with vascularized fibula grafts (VFG) after intercalary resection of sarcoma may offer longevity by providing early graft-host union and fracture healing. The ability the to hypertrophy under mechanical stress, as well bone in area, also be advantageous, given that soft tissues compromised because resection, chemotherapy, or radiation therapy. VFG a massive allograft combines primary stability graft biological potential fibula; however, complications durability this combined...
Immune checkpoint inhibitors (ICIs) have led to a paradigm shift in non-small cell lung cancer (NSCLC) treatment. We investigated absolute eosinophil count (AEC) as predictor of clinical outcomes and toxicity NSCLC patients receiving ICIs.AEC was retrospectively collected at baseline during treatment from 158 advanced treated with single agent anti-PD1/anti-PDL1 monoclonal antibody first or subsequent line therapy Medical Oncology Unit, Careggi University Hospital, Florence (Italy), between...
(1) Background: We aim to address the following questions. What was complication rate of vascularized fibula graft (VFG) combined with massive allograft in patients treated joint-sparing resection around knee for a high-grade osteosarcoma? long-term survivorship VFG free from revision and removal? were functional results as assessed by Musculoskeletal Tumor Society (MSTS) score? (2) Methods: 39 our unit osteosarcoma intercalary reconstruction included; 26 underwent tibial resection, while 13...
Background: Soft tissue sarcomas (STSs) are rare, highly malignant mesenchymal tumours, comprising approximately 1% of all adult cancers and about 15% paediatric solid tumours. STSs exhibit considerable genomic complexity with diverse subtypes, posing significant clinical challenges. Objectives: This study aims to characterise the molecular signature primary STS through liquid biopsies untargeted metabolomic profiling 75 patients, providing deep insights into cellular processes potential...
Clinical responses to anticancer therapies in advanced soft tissue sarcoma (STS) are unluckily restricted a small subgroup of patients. Much the inter-individual variability treatment efficacy is as result polymorphisms genes encoding proteins involved drug pharmacokinetics and pharmacodynamics. The nucleotide excision repair (NER) system main defense mechanism for repairing DNA damage caused by carcinogens chemotherapy drugs. Single (SNPs) NER pathway key genes, altering mRNA expression or...
Neutrophil-to-eosinophil ratio (NER) has been described to be associated with outcomes immune checkpoint inhibitors (ICI) in several tumor types, but less is known about its role of the response avelumab advanced urothelial cancer (aUC). Thus, we reported by NER aUC patients treated as maintenance after initial platinum-based chemotherapy and enrolled Maintenance AVeLumAb ([MALVA] neoplasms first-line chemotherapy: an observational retrospective study) study (Meet-URO 25).
Introduction Epithelioid hemangioendothelioma (EHE) is an ultra-rare sarcoma, marked by distinctive molecular and pathological features with a variable clinical behavior. Its natural history still partially understood, reliable prognostic predictive factors are lacking many questions open on the optimal management. In context of EURACAN, prospective registry specifically dedicated to EHE was developed launched aim providing, through high-quality data collection, better understanding this...
DSI Underground developed a bolt, based on frictional, inflatable bolt combined with an internal additional load-bearing element, called the Dynamic Omega-Bolt.This paper provides technical detail of design and results laboratory tests its performance.Laboratory drop conducted at CanmetMINING laboratories suggest that under dynamic loading, exhibits peak tensile strength frictional element residual loading capacity from element.Failure both elements corresponds to average absorption 35 kJ...
Key Points1.No prognostic markers are available in gastric cancer patients after neoadjuvant chemotherapy.2. TRG is a surrogate of survival outcomes.3. TRG-high/ATM-expressed/SIRT1-absent profile should be prospectively investigated as marker for stratification.
The detection of RAS mutations and co-mutations in liquid biopsy offers a novel paradigm for the dynamic management metastatic colorectal cancer (mCRC) patients. Expanding results prospective OMITERC (OMIcs application from solid to personalized ThERapy Cancer) project, we collected blood samples at specific time points patients who received first-line chemotherapy (CT) KRAS-mutated mCRC. CTC quantification was performed by CellSearch® system. Libraries cfDNA were prepared using Oncomine™...
Pancreatic adenocarcinoma (PC) is one of the most lethal malignancies; even after resection patients' 5-year disease-free survival (DFS) lower than 26%. The genetic mutational landscape PC dominated by activating KRAS mutations, that have been reported in approximately 90% cases; however, beyond - direct several KRAS-targeting miRNAs appear to be downregulated, strengthening already activated RAS signaling. In addition, interplay between and includes poorly investigated downstream miRNAs....
e16503 Background: In regard to resectable muscle-invasive bladder cancer (MIBC) patients, treatment with radical cystectomy (RC) and perioperative platinum-based chemotherapy (CT) (neoadjuvant or adjuvant) represents the standard of care. Perioperative can improve overall survival (OS), most robust evidence are in favor neoadjuvant CT. RealBLADDER is an observational study aiming describe use impact on CT for patients MIBC Italian real-world setting. Methods: a multicentric, observational,...
The purpose of the study was to answer following questions. What functional results pediatric patients receiving a short stem allograft-prosthesis composite proximal femur? complication rate and revision-free implant survival? Was it possible preserve bone stock femur in patients?
Few data are available about results after procedures of resection and megaprosthesis at the hip in very elderly patients. The aim our study was to ascertain survival complications patients aged 80 or older undergoing these major orthopedic procedures. A consecutive series 27 26 80-93 years evaluated. In total, 15 were performed due oncological diseases, 6 following joint arthroplasty failures periprosthetic fractures, trauma sequelae. Survival ranged from 0 122 months. Overall 56% 3 years,...
e16570 Background: Platinum-based chemotherapies (CTs) represent the standard first-line treatment of advanced urothelial carcinoma (aUC). However, development resistance and toxicities to these regimens is responsible for poor progression-free survival (PFS) overall (OS). Maintenance with programmed death-ligand 1 (PD-L1) inhibitor avelumab after initial response CT improved significantly OS. Despite advantage, only a limited percentage patients (pts) benefits from immunotherapy. Therefore,...
e16314 Background: Pancreatic adenocarcinoma (PC) is one of the big killers with a 5-year disease-free survival (DFS) rate 19-26% after resection despite adjuvant treatments. KRAS mutations have been reported in approximately 90% PC cases and, beyond activation by gene mutations, several miRNAs directly targeting to be simultaneously downregulated, strengthening already activated RAS signaling. In addition, interplay between and includes downstream miRNA effectors whose role needs...
e14016 Background: The increasing overall survival in cancer patients, due to advances diagnostics and treatments, lead an expected increase diagnoses of brain metastasis (BM). A relevant feature care-management this special population is the safety anticoagulant therapies administration, since cancer-associated thrombosis (CAT) a concrete complication patients with BM. In BM risk developing AEs local treatments (i.e. radiation), bleeding critical issue. Hence, understanding risk/benefit...
Boliden strives to increase efficiency and quality, enable automation during bolting operations.To this effect, a trial with hollow bar rockbolts pumpable resin as grouting was performed at the Renström mine.As part of trial, tests were carried out verify capacities new bolt determine required anchor length needed.In initial testing 2020 using from DSI Underground (DSI) standard steel (R25, 22 t ultimate strength, 5% deformation capacity) results showed that strength good, slightly longer...
Abstract Background: Platinum chemotherapy (CT) remains the backbone of systemic therapy for patients with small-cell lung cancer (SCLC). The nucleotide excision repair (NER) pathway plays a central role in DNA damages exerted by platinum agents. Alteration this mechanism may affect survival. Methods: We retrospectively collected data from 38 extended disease (ED)-SCLC treated platinum-CT at Clinical Oncology Unit, Careggi University Hospital, Florence (Italy), between 2015 to 2020. On...