A5027715206- Lipoproteins and Cardiovascular Health
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Immunotherapy and Biomarkers
- Diabetes Management and Research
- Pancreatic and Hepatic Oncology Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer, Lipids, and Metabolism
- Cancer Genomics and Diagnostics
- Cholesterol and Lipid Metabolism
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Diet and metabolism studies
- Frailty in Older Adults
- Neuroendocrine Tumor Research Advances
- Renal cell carcinoma treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Diet, Metabolism, and Disease
- Lung Cancer Treatments and Mutations
- Drug Transport and Resistance Mechanisms
- Chromatin Remodeling and Cancer
- HER2/EGFR in Cancer Research
- Chronic Disease Management Strategies
- Cancer Mechanisms and Therapy
- Chemotherapy-related skin toxicity
Azienda Ospedaliero-Universitaria Careggi
2015-2025
University of Modena and Reggio Emilia
2008-2020
Azienda Unita' Sanitaria Locale Di Modena
2008-2010
Atezolizumab plus Bevacizumab (atezobeva) has changed the treatment landscape of advanced hepatocellular carcinoma (HCC), but its efficacy and safety in patients with impaired liver function are still debated. This study aimed to evaluate prognostic impact baseline decompensation during on clinical outcomes. In this multicenter study, we included 247 or unresectable HCC treated atezobeva. We analyzed data survival, tumor progression, introduced time (TTD) as a new endpoint. The reported...
The modifications of cholesterol metabolism associated with aging are ill-defined. objective this study was to define age-associated alterations the different metabolic pathways controlling homeostasis by analyzing circulating sterols.We analyzed serum samples collected from 201 adult (75 male, 126 female) subjects within epidemiological MICOL (Multicentrica Italiana Colelitiasi). age range 38-79 years; 103 had evidence gallstones. concentrations sterols, recognized as markers main...
About half of metastatic colorectal cancers (CRCs) harbor Rat Sarcoma (RAS) activating mutations as oncogenic driver, but the prognostic role RAS is not fully elucidated. Interestingly, specific hotspot have been identified potential candidates for novel targeted therapies in several malignancies per G12C. This study aims at evaluating association between KRAS and patient characteristics, prognosis response to antiangiogenic drugs.Data from RAS-mutated CRC patients referred Careggi...
Background: To date, no biomarkers are effective in predicting the risk of developing immune-related adverse events (irAEs) patients treated with immune checkpoint inhibitors (ICIs). This study aims to evaluate association between basal absolute eosinophil count (AEC) and irAEs during treatment ICIs for solid tumors. Methods: We retrospectively evaluated 168 metastatic melanoma (mM), renal cell carcinoma (mRCC), non-small lung cancer (mNSCLC) receiving at our medical oncology unit. By...
Lipoprotein glomerulopathy is a pathological condition characterized by lipid accumulation in the glomerular capillaries that has been associated with presence of rare mutants apolipoprotein E (ApoE). We describe 51-year-old Italian patient presenting Type III hyperlipidemia and proteinuria whom renal biopsy showed capillary ectasia intraluminal deposits, suggesting diagnosis lipoprotein glomerulopathy. The patient, who had elevated plasma ApoE level, was found to be heterozygous for...
Coronary artery disease is the leading cause of morbidity and mortality in patients with type 2 diabetes. Screening for asymptomatic coronary treatment by means revascularization seems to be an appealing option prevention. The utility such a strategy has never been challenged randomized trial.
Somatostatine analogs (SSAs) are currently indicated in the treatment of acromegaly and neuroendocrine tumors (NETs). Actually, pregnancy patients with NETs does not represent an exceptional event because reproductive behavior has changed last decades show more frequently long-term survival. The safety profile SSAs during is still controversial. Concerning acromegaly, based on case reports series, administration seems to be relatively well tolerated. NETs, up date only one patient NET...
e21144 Background: Immune Checkpoint Inhibitors (ICIs) changed the algorithm of treatment for Non-Small Cell Lung Cancer (NSCLC). Consequently, an increased incidence specific immune-related adverse events (irAEs) were reported, although a clear relationship between toxicity and response to ICIs was not identified. To date no strong predictive factor are univocally recognized in NSCLC. Methods: This is observational, retro-prospective, monocentric study aimed evaluate, patients (pts) with...
Key Points1.No prognostic markers are available in gastric cancer patients after neoadjuvant chemotherapy.2. TRG is a surrogate of survival outcomes.3. TRG-high/ATM-expressed/SIRT1-absent profile should be prospectively investigated as marker for stratification.