A5100356766- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Influenza Virus Research Studies
- Virus-based gene therapy research
- Animal Disease Management and Epidemiology
- Viral Infections and Immunology Research
- interferon and immune responses
- Hepatitis C virus research
- Respiratory viral infections research
- Hepatitis B Virus Studies
- Retinal Diseases and Treatments
- Proteins in Food Systems
- Herpesvirus Infections and Treatments
- Microencapsulation and Drying Processes
- Probiotics and Fermented Foods
- Liver Disease Diagnosis and Treatment
- Immune Cell Function and Interaction
- Retinal Imaging and Analysis
- Virology and Viral Diseases
- Systemic Lupus Erythematosus Research
- Immune Response and Inflammation
- Viral Infectious Diseases and Gene Expression in Insects
- RNA Research and Splicing
- Monoclonal and Polyclonal Antibodies Research
- Vector-Borne Animal Diseases
Affiliated Eye Hospital of Wenzhou Medical College
2021-2024
Wenzhou Medical University
2021-2024
Chinese Academy of Agricultural Sciences
2005-2024
Lanzhou Veterinary Research Institute
2010-2024
Wuhan Sixth Hospital
2019-2024
Nanjing University
2024
Lanzhou University
2024
Hubei University Of Economics
2023-2024
Wuxi Vocational Institute of Commerce
2024
Nanjing Agricultural University
2024
The emergence of SARS-CoV-2 variants with evidence antibody escape highlight the importance addressing whether total CD4
We identified from suckling piglets with diarrhea in China a new bat-HKU2-like porcine coronavirus (porcine enteric alphacoronavirus). The GDS04 strain of this shares high aa identities (>90%) the reported bat-HKU2 strains Coronaviridae-wide conserved domains, suggesting that belongs to same species as HKU2.
Chronic hepatitis B (CHB) is characterized by functionally impaired virus‐specific CD 8 + T ‐cell responses. However, the mechanism underlying this dysfunction has not been fully clarified. We examined role of a newly identified protein, immunoglobulin domain and mucin domain‐containing molecule‐3 ( im‐3), in regulating antiviral response CHB patients. im‐3 expression on peripheral cells from 20 patients healthy controls was determined flow cytometry. The phenotypes cytokine‐producing...
An outbreak of egg drop disease occurred in many chicken and goose farms China 2011. By using an NS5-specific reverse transcriptase PCR (RT-PCR), we found that 56% 38% samples were positive for Tembusu-like virus (TMUV). Isolates showed high sequence homology to duck TMUVs, chickens geese signs after experimental infection with TMUV. Our data suggest TMUV has adapted domestic birds.
In this study, oil-in-water emulsions made of medium-chain triglycerides (MCT), mucilage from Dioscorea opposita (DOM), and food-grade polysaccharides (guar gum [GG], xanthan [XG] pectin [Pec]) were prepared using high-pressure homogenisation. The droplet size distributions, microstructure, turbidity, interfacial tension, creaming index, stability investigated compared with those DOM, GG, XG Pec. results showed that 0.4 wt% (GG, XG, Pec) 2 DOM contributed more to the emulsion during storage....
Porcine deltacoronavirus (PDCoV) is a newly identified virus that causes watery diarrhea in newborn piglets and results significant economic losses to the pig industry. Since first reported Hong Kong 2012, PDCoV has been subsequently detected USA, South Korea, Thailand, mainland China. Here we isolated strain of PDCoV, named CHN-GD-2016, from intestinal content diseased piglet with severe farm Guangdong, CHN-GD-2016 could be by immunofluorescence specific rabbit antisera, typical...
Fowl adenoviruses (FAdVs) are associated with many diseases, resulting in huge economic losses to the poultry industry worldwide. Since 2015, outbreaks of FAdV infections high mortality rates have been reported China. A continued surveillance FAdVs contributes understand epidemiology viruses.We isolated 155 strains from diseased chickens China between 2015 and 2018. PCR analysis determined that 123 samples were species C, 27 E, five contained two different strains. The phylogenetic...
Bisphenol A (BPA), a ubiquitous endocrine-disrupting chemical, is commonly used as plasticizer to manufacture various food packaging materials. Evidence has demonstrated that BPA disturbed bone health. However, few studies focused on the effect of osteocytes, making up over 95% all cells. Here, we reported inhibited cell viability MLO-Y4 cells, and increased apoptosis in dose-dependent manner. Furthermore, up-regulated protein expressions speck-like containing CARD (ASC), NLRP3, cleaved...
Polyglycerol polyricinoleate (PGPR) was used as the oil-soluble surfactant and beeswax oil phase to formulate a water-in-oil (W/O) high internal emulsions (HIPEs) for encapsulation protection of probiotics. The physicochemical properties W/O HIPEs survival encapsulated probiotics when exposed acidic conditions in vitro digestion were investigated. viability decreased slightly high-speed shearing. rheological analysis, microstructural images, stability showed that remained relatively stable....
Porcine enteric alphacoronavirus (PEAV) was first discovered in China February 2017, and the origin virulence of this novel porcine coronavirus were not fully characterized. Here, we isolated a strain PEAV, named GDS04 that is identified by immunofluorescence typical crown-shaped particles observed with electron microscopy. Genomic analysis reveals PEAV shares close relationship SADS-CoV SeACoV. Furthermore, newborn piglets orally challenged developed clinical symptoms as watery diarrhoea...
ABSTRACT The formation of neuronal dendrite branches is fundamental for the wiring and function nervous system. Indeed, branching enhances coverage neuron's receptive field modulates initial processing incoming stimuli. Complex patterns are achieved in vivo through a dynamic process de novo branch formation, extension retraction. first step towards generation filopodium-like branchlet. mechanisms underlying initiation branchlets therefore crucial to shaping dendrites. Through time-lapse...
Our study aimed to evaluate the effect of circular RNA ABCB10 (circ-ABCB10) on proliferation and apoptosis clear cell renal carcinoma (ccRCC) cells, its prognostic value in patients with ccRCC.Circ-ABCB10 expression five ccRCC lines normal kidney epithelial line was measured by quantitative polymerase chain reaction (qPCR). Empty overexpression, circ-ABCB10 empty shRNA, shRNA plasmids were transfected into A498 cells as negative control for over {NC (+)}, Circ-ABCB10(+), (-){NC(-)},...
Thymol has been applied as a spice and antibacterial agent in commercial products. However, the utilization of thymol food pharmaceutical field recently limited by its poor water solubility stability. In this work, caseinate-stabilized nanosuspension was fabricated pH-driven methods to overcome those limitations. Firstly, chemical stability at different pH value conditions investigated. The physiochemical properties nanosuspensions were then characterized, such average particle size, zeta...
Inactivated vaccines lack the capability to serologically differentiate between infected and vaccinated animals, thereby impeding effective eradication of pathogen. Conversely, based on virus-like particles (VLPs) emulate natural viruses in both size antigenic structure, presenting a promising alternative overcome these limitations. As complexity swine infectious diseases increases, increase vaccine types doses may intensify stress response. This exacerbation can lead diminished...
Since a novel hyper-virulent fowl adenovirus serotype 4 (FAdV-4) infection occurred in 2015, the FAdV-4 has been widely spreading across China, causing significant economic losses to poultry industry. As urgency of issue calls for effective and efficient solutions, present study investigated possibility fiber-2 protein serve as vaccine candidate against FAdV-4. In research, proteins were expressed Escherichia coli, then purified. To evaluate immunogenicity recombinant protein, we both...
Background It is difficult to prospectively differentiate between benign (World Health Organization [WHO] I) and nonbenign (WHO II III) meningiomas. Purpose To evaluate the feasibility of preoperative differentiation meningiomas by using texture analysis from multiparametric MR data. Study Type Retrospective. Subjects In all, 184 patients with meningioma (139 45 nonbenign) were included as training cohort 79 (60 19 external validation cohort. Field Strength/Sequence T 1 ‐weighted, 2...
Background: Both leisure activities and the ε4 allele of apolipoprotein E ( APOE ε4) have been shown to affect cognitive health. We aimed determine whether engagement in protects against ε4-related decline. Methods: used cohort data from Chinese Longitudinal Healthy Longevity Survey. A total 3,017 participants (mean age 77.0 years, SD = 9.0; 49.3% female) 23 provinces China were recruited 2008 reinterviewed 2014. assessed function using Mini-Mental State Examination (MMSE). calculated...
Abstract Rammed earth is a kind of cleaning material, widely used in all kinds buildings the world. The Great Wall ancient China typical world cultural site built from rammed earth. Shanhaiguan close to Bohai Bay, which has suffered long-term erosion by rain, causing series problems such as soil loss, collapse and gully flushing. protection materials have always puzzled scholars. However, during rainy season, it was found that some walls at Xiaowan Gouge Nantuzhuang had unwashed traces,...