A5101701171- Protein Structure and Dynamics
- Liver Disease Diagnosis and Treatment
- Enzyme Structure and Function
- Gut microbiota and health
- Diet and metabolism studies
- RNA and protein synthesis mechanisms
- Mass Spectrometry Techniques and Applications
- Helicobacter pylori-related gastroenterology studies
- Nutritional Studies and Diet
- Magnetic confinement fusion research
- Congenital Heart Disease Studies
- Esophageal Cancer Research and Treatment
- Liver Disease and Transplantation
- Pulmonary Hypertension Research and Treatments
- Gastric Cancer Management and Outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Epilepsy research and treatment
- Toxin Mechanisms and Immunotoxins
- RNA modifications and cancer
- Fusion materials and technologies
- Diet, Metabolism, and Disease
- Viral Infectious Diseases and Gene Expression in Insects
- Nuclear reactor physics and engineering
- Intestinal and Peritoneal Adhesions
- Cancer, Hypoxia, and Metabolism
Hirosaki University
2014-2025
Prefectural University of Kumamoto
2022-2023
Hokkaido Pharmaceutical University
2023
Hokkaido University
2023
Kamituga General Hospital
2020
Tokyo Medical University
2016
Stony Brook University
1999-2014
University of Tsukuba
1986-2011
Kyoto University
2010
Medical Research Council
2004-2005
Φ values are used to map structures of protein-folding transition states from changes in free energies denaturation (ΔΔ G D-N ) and activation on mutation. A recent reappraisal proposed that for ΔΔ < 1.7 kcal/mol artifactual. On discarding such derived published studies, the authors concluded there no high diffuse states, which consequently uniformly with evidence nucleation. However, > often found large side chains make dispersed tertiary interactions, especially hydrophobic cores...
To examine an association between self-reported sleep quality determined by Pittsburgh index (PSQI) and metabolic syndrome. This study was designed as cross-sectional study. Participants were 1481 adults aged 20 years above from general population (549 males 932 females). We assessed the global PSQI. PSQI consists of 7 elements, i.e. subjective quality, latency (prolonged onset time), duration, habitual efficiency (proportion hours slept to spent in bed), disturbance (interruption sleep),...
There is considerable interest in small proteins that fold very rapidly. These have become attractive targets for both theoretical and computational studies. The independently folded 36-residue villin headpiece subdomain has been the subject of a number such studies predicted to quickly. We demonstrate using dynamic NMR line-shape analysis protein folds on time scale 10 μs. Folding rates were directly estimated between 56 78 °C resolved resonances from three different residues at 500 700...
Significance Unfolded and partially unfolded proteins participate in a wide range of biological processes from pathological aggregation to the regulation normal cellular activity. Characterization nonnative states is critical for understanding these processes, yet comparatively little known about their energetics structural propensities under native conditions. We demonstrate that energetically important interactions, which involve multiple residues include significant effects, can form...
We encountered a case demonstrating high confluence of the pancreaticobiliary ducts with frequent acute pancreatitis recurrence in absence alcohol consumption and gallstones. The patient presented to our hospital after 12 episodes was subsequently admitted which diagnosed be severe by CT grade according Japanese Ministry Health, Labour Welfare severity criteria 2008. After recovery, endoscopic retrograde cholangiopancreatography revealed an 8-mm common duct only during papillary sphincter...
Background/Objective: This study investigated the relationship between composition of oral microbiota and metabolic dysfunction-associated steatotic liver disease (MASLD) in general population. Methods: In total, 712 participants a health check-up project were divided into four patterns by principal component analysis cluster analysis; they included Neisseria, Streptococcus, Fusobacterium, Veillonella groups. The Neisseria group had largest number patients was used as reference to compare...
We attempted to evaluate a novel purification method of immunoglobulins (IgGs) by using mutant type protein A. Although this A binds IgGs at 5°C, the are released 40°C; hence, it was designated as thermo-responsive (TRPA). aimed purify IgG1 from culture supernatant CHO cells producing AE6F4 human monoclonal IgG1. purified only TRPA-filled column and modifying temperature, without any exposure acidic conditions. Furthermore, maintained inherent binding affinity antigen, while property lost in...
This study aimed to determine the clinical difference of pneumonia between penicillin-resistant and penicillin-sensitive Streptococcus pneumoniae.Forty-nine cases in 46 patients pneumococcal were studied from December 1992 May 1997. There 24 (in 22 patients) pneumococci (PRSP) which compared with 25 (PSSP).Both mean age underlying disease states did not differ two groups. However, hospital-acquired previous use antibiotics observed eight (33.3%) 12 (50.0%) PRSP three (12.0%) (8.0%) PSSP,...
We investigated the age distribution of typus melancholicus (TM) score, measured by Kasahara's scale, in 119 outpatients with major depression and 600 workers without a history depression. In patient group, score was, regardless age, always constant at high level. The TM for control group increased aging was most groups significantly lower than that group. This result suggests higher on scale would be risk factor possible trait marker
Viscosities of aqueous solutions guanidine hydrochloride (GuHCl) were measured in the presence varying amounts glucose. At high concentrations glucose or GuHCl, viscosities showed significant deviation from values computed using a method proposed by Tanford (1966, J Biol Chem 241:3228-3232). This was originally derived to allow calculation effects buffer low salts and other additives on density viscosity urea GuHCl. Recently it has been used estimate denaturant that contain viscogens. Our...
Patients with lean nonalcoholic fatty liver disease (NAFLD) may have different metabolic profiles than those NAFLD. Estrogenic activity is associated NAFLD pathogenesis. We evaluated the production ability of equol, which has estrogenic activity, in and assessed their gut microbiota relation to equol-producing ability. Among 684 adult participants, 276 (40%) had 293 (43%) were equol producers. The rates producers normal groups 43% 42%, respectively. patients NAFLD, 55 (20%) 18 (33%) rate men...
Urine is a major source of reclaimed water and fertilizer. treatment involves two key processes: the recovery nutrients rejection trace organic compounds (TOrCs). In this study, we investigated TOrCs in human urine using seawater-driven forward osmosis membrane distillation (FO-MD) hybrid system. Three 24 h experiments were conducted at draw solution temperatures 30, 40, 50 °C. The average rates cations, anions, dissolved carbon more than 93.7% 79.5% FO-MD system FO side, respectively. Ten...
Many factors are associated with the development and progression of metabolic dysfunction-associated steatotic liver disease (MASLD); however, genetics gut microbiota representative factors. Recent studies have highlighted link between host genes microbiota. Although there been many on separate effects single nucleotide polymorphisms (SNPs) bacteria MASLD, few epidemiological examined how SNPs interact in MASLD. This study aimed to investigate association PNPLA3 rs738409, a MASLD-related...
Levels of messenger RNA (mRNA) extracted from five samples radicular cyst-lining epithelium were analyzed for cytokines, growth factors and epithelial cell growth-related receptors by RT-PCR. All expressed IL-1α, -1β, IL-6, IL-8, IL-11, TGF-β1, PDGF-A aFGF, EGF (c-erbB), KGF, HGF (c-met) IL-6. Some the specimens MIP-1α, RANTES, GM-CSF, M-CSF, TNF-α, PDGF-B bFGF, but no expression IL-2, IL-4, IFN-γ, IGF-I, KGF was detected. These results indicate that epithelium, which is considered to be...