A5109011359- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Ocular Diseases and Behçet’s Syndrome
- Intraocular Surgery and Lenses
- Retinal and Macular Surgery
- Glaucoma and retinal disorders
- Cerebral Venous Sinus Thrombosis
- Migraine and Headache Studies
- Indian History and Philosophy
- Ocular Oncology and Treatments
- Nitric Oxide and Endothelin Effects
- Cerebrospinal fluid and hydrocephalus
- Ocular Infections and Treatments
- Vascular Malformations Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Coronary Interventions and Diagnostics
- Retinopathy of Prematurity Studies
- Image and Signal Denoising Methods
- Cardiac Imaging and Diagnostics
- Advanced Image Processing Techniques
- Retinal Development and Disorders
- Fetal and Pediatric Neurological Disorders
- Indian and Buddhist Studies
- Hormonal Regulation and Hypertension
Chandigarh University
2022-2025
AdventHealth Orlando
2023-2024
GLA University
2022
Eastern Virginia Medical School
2014-2021
The Retina Center
2013-2021
Wagner College
2021
Retina Institute
2021
Jawaharlal Nehru University
2012-2018
University of Michigan
2017
Mayo Clinic
2012-2016
An unbiased systems approach was used to define energy metabolic events that occur during the pathological cardiac remodeling en route heart failure (HF).Combined myocardial transcriptomic and metabolomic profiling were conducted in a well-defined mouse model of HF allows comparative assessment compensated decompensated (HF) forms hypertrophy because pressure overload. The overload data sets also compared with transcriptome metabolome for an adaptive (physiological) form endurance exercise...
ABSTRACT Medial vascular calcification (MVC) is a pathological phenomenon that causes stiffening and can lead to heart failure; it common variety of conditions, including aging, chronic kidney disease, diabetes, obesity, rare genetic diseases. These conditions share the feature tissue-nonspecific alkaline phosphatase (TNAP) upregulation in vasculature. To evaluate role TNAP MVC, we developed mouse model overexpresses human smooth muscle cells an X-linked manner. Hemizygous overexpressor male...
Age-associated arterial remodeling involves wall collagen deposition and elastin fragmentation, as well an increase in pressure. This is linked to proinflammatory signaling, including transforming growth factor-β1, monocyte chemoattractant protein 1, proendothelin activated by extracellular matrix metalloproteinases (MMPs) orchestrated, part, the transcriptional factor ets-1. We tested hypothesis that inhibition of MMP activation can decelerate age-associated proinflammation its attendant...
Wnt signaling regulates key aspects of diabetic vascular disease.We generated SM22-Cre;LRP6(fl/fl);LDLR(-/-) mice to determine contributions coreceptor low-density lipoprotein receptor-related protein 6 (LRP6) in the smooth muscle lineage male receptor-null mice, a background susceptible diet (high-fat diet)-induced arteriosclerosis.As compared with LRP6(fl/fl);LDLR(-/-) controls, (LRP6-VKO) siblings exhibited increased aortic calcification on high-fat without changes fasting glucose,...
Abstract Warfarin sodium has been associated with leucocytoclastic vasculitis and once allergic interstitial nephritis. Hypersensitivity to warfarin simultaneously resulting in nephritis not yet previously reported. We present a 48‐year‐old man who was on for 2 months presented acute renal failure reddish purplish macules his hypogastric regions lower extremities bilaterally. Kidney biopsy showed punch skin vasculitis. Both biopsies also high eosinophil count, highly suggestive of...
<b><i>Background and Objective:</i></b> Overaction of mineralocorticoid receptor (MR) pathways has been implicated in the pathophysiology central serous chorioretinopathy (CSCR). The purpose this study was to evaluate MR antagonists treatment CSCR. <b><i>Study Design Methods:</i></b> A retrospective chart review conducted all CSCR patients at one center treated with spironolactone or eplerenone (50 mg p.o. b.i.d.) observation. Patients were...
ABSTRACT Introduction PCSK9 inhibitors are a novel class of medications that lower LDL cholesterol (LDL‐C) by increasing receptor activity, promoting clearance LDL‐C from the bloodstream. Over years, have been explored as adjunct therapies to statins or monotherapy in high‐risk cardiovascular patients. Aim This review aims provide an updated perspective on inhibitors, assessing their clinical efficacy, safety, and significance, especially light recent trials. Methods The examines role...
Treatment options for large subglottic haemangioma include steroids, laser ablation, open excision, tracheostomy and, more recently, propranolol. This article aims to present the Great Ormond Street Hospital guidelines using propranolol treat infantile isolated by ENT surgeons.The vascular malformations multidisciplinary team at has developed treating with propranolol.The treatment investigation, and follow up. Propranolol is started 1 mg/kg/day divided into three doses, increasing 2 one...
IMPORTANCEAs the United States considers how to best structure its health care services, specialty availability is receiving increased focus.This study assesses whether patients lack reasonable access ophthalmologists in states where optometrists have been granted expanded scope of practice.OBJECTIVE To determine estimated travel time (ETT) nearest ophthalmologist office for persons residing that practice optometrists, and quantify ETT Medicare beneficiaries who received surgical from those...
Abstract Background Laser skin resurfacing is a popular cosmetic procedure for noninvasive rejuvenation. Since health insurance plans often do not cover these types of procedures, patients pay out pocket. Consequently, there an incentive to go abroad, where prices are more affordable. However, practitioners in destination countries may lack rigorous training on laser safety, regulatory oversight, or licensing, especially devices used “cosmetic” procedures. In certain cases, this can lead...
In recent years, companies, consumers and the media have all shown an interest in cryptocurrency, most notably Bitcoin, which has led to significant investment. A cryptocurrency is a type of digital money that serves as intermediate trade. Even though lots individuals are aware few use it. However, it unclear what motivates customer adoption technology. Undoubtedly, market split people’s views; while some want learn more about it, others totally against utilising this cutting-edge The...
Calcitonin gene‐related peptide (CGRP), a potent vasodilator released from capsaicin‐sensitive trigeminal sensory nerves, seems to be involved in the pathogenesis of migraine. Hence, CGRP receptor antagonists may serve as novel treatment for This study was therefore designed investigate effects BIBN4096BS (100, 300 and 1000 μ g kg −1 , i.v.), selective antagonist, on capsaicin‐induced carotid haemodynamic changes anaesthetised pigs. Both vagosympathetic trunks were cut phenylephrine infused...
The arachnoid granulations (AGs) are herniations of the membrane into dural venous sinuses on surface brain. Previous morphological studies AGs have been limited in scope and only one has mentioned area measurements. purpose this study was to investigate topographic distribution superior cerebral cortex. En face images were taken 35 formalin-fixed human brains. manually identified using Adobe Photoshop, with a pixel location containing an AG defined as 'positive'. A set 25 standard fiducial...
Exudative retinal detachment is the most common source of visual loss associated with malignant melanoma uveal tract. Management has historically been conservative, leading to irreversible from photoreceptor damage during several months needed for post-radiation resolution. The purpose this paper describe timely vitreoretinal surgical intervention exudative detachments choroidal melanomas. This was an interventional case series including six consecutive patients who experienced VA reduction...
Limited data have evaluated multiple injections of the dexamethasone 700 μg implant (DEX) (Ozurdex; Allergan, Inc.) for cystoid macular edema (CME) secondary to retinal vein occlusion (RVO) over an extended regimen.This retrospective study patients treated with DEX CME associated RVO. Each patient had ophthalmologic evaluation, optical coherence tomography (OCT), and 4 weeks 6 follow-up intervals. Retreatment criterion was fluid on OCT. Outcome measures included best-corrected visual acuity,...