A5068520969- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Memory and Neural Mechanisms
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Advanced Fluorescence Microscopy Techniques
- Neonatal and fetal brain pathology
- Zebrafish Biomedical Research Applications
- EEG and Brain-Computer Interfaces
- Olfactory and Sensory Function Studies
- CCD and CMOS Imaging Sensors
- bioluminescence and chemiluminescence research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cell Image Analysis Techniques
- Optical Imaging and Spectroscopy Techniques
- Traumatic Brain Injury Research
- Visual perception and processing mechanisms
University of Minnesota
2020-2025
Twin Cities Orthopedics
2020-2024
>2.5 million individuals in the United States suffer mild traumatic brain injuries (mTBI) annually. Mild TBI is characterized by a brief period of altered consciousness, without objective findings anatomic injury on clinical imaging or physical deficit examination. Nevertheless, subset mTBI patients experience persistent subjective symptoms and repeated can lead to quantifiable neurological deficits, suggesting that each alters neurophysiology deleterious manner not detected using current...
Recently developed miniaturized neural recording devices that can monitor and perturb activity in freely behaving animals have significantly expanded our knowledge of underpinning complex behaviors. Most interfaces require a wired connection for external power data acquisition systems. The wires are required to be commutated through slip ring accommodate twisting the wire or tether alleviate torsional stresses. increased trend toward long-term continuous recordings has spurred efforts...
Despite the availability of various anti-seizure medications, nearly 1/3 epilepsy patients experience drug-resistant seizures. These are left with invasive surgical options that do not guarantee seizure remission. The development novel treatment depends on elucidating complex biology seizures and brain networks. We aimed to develop an experimental paradigm uses anatomical network information, functional connectivity, in vivo models determine how networks, their manipulation, affect...
Abstract Recently developed miniaturized neural recording devices that can monitor and perturb activity in freely behaving animals have significantly expanded our knowledge underpinning of complex behaviors. Most interfaces require a wired connection for external power data acquisition systems. The wires are required to be commutated through slip ring accommodate twisting the wire or tether alleviate torsional stresses. increased trend towards long term continuous recordings spurred efforts...
Here, we introduce a miniaturized multi camera microscope that can simultaneously capture cellular resolution neural activity from multiple large fields of view the cortex in freely moving mouse.
Understanding how circuits in the brain simultaneously coordinate their activity to mediate complex ethnologically relevant behaviors requires recording neural activities from distributed populations of neurons freely behaving animals. Current miniaturized imaging microscopes are typically limited a relatively small field view, precluding measurement across multiple regions. Here we present micro-camera array microscope (mini-MCAM) that consists four fluorescence micro-cameras, each capable...
Spatial navigation is a complex cognitive process that involves neural computations in distributed regions of the brain. Little known about how cortical are coordinated when animals navigate novel spatial environments or coordination changes as become familiar. We recorded mesoscale calcium (Ca
Summary Decision-making during freely moving behaviors involves complex interactions among many cortical and subcortical regions. However, the spatiotemporal coordination across regions to generate a decision is less understood. Using head-mounted widefield microscope, cortex-wide calcium dynamics were recorded in mice expressing GCaMP7f as they navigated an 8-maze using two paradigms. The first was alternating pattern that required short term memory of previous trial make correct second...
Spatial navigation is a complex cognitive process that involves neural computations in distributed regions of the brain. Little known about how cortical are coordinated when animals navigate novel spatial environments or coordination changes as become familiar. We recorded mesoscale calcium (Ca
The advent of genetically-encoded calcium indicators, along with surgical preparations such as thinned skulls or refractive index matched skulls, have enabled mesoscale cortical activity imaging in headfixed mice. Such studies revealed complex patterns coordinated across the surface during a variety behaviors. However, neural free, unrestrained behavior significantly differs from that observed animals. ability to perform cortex freely behaving mice may launch new avenues scientific enquiry....
ABSTRACT The advent of genetically encoded calcium indicators, along with surgical preparations such as thinned skulls or refractive index matched skulls, have enabled mesoscale cortical activity imaging in head-fixed mice. Such studies revealed complex patterns coordinated across the cortex during spontaneous behaviors, goal-directed behavior, locomotion, motor learning, and perceptual decision making. However, neural unrestrained behavior significantly differs from animals. Whole-cortex...
The mini-mScope is a wide-field miniaturized, head-mounted fluorescence microscope for imaging in freely behaving mice. We demonstrate recording mesoscale calcium activity across the dorsal cortex during sensory-evoked stimuli, open field behaviors, and social interactions.
Abstract The physiologic basis underlying the long-term consequences of repetitive, mild traumatic brain injury (mTBI) remains poorly understood. Mild often results in brief loss consciousness, impaired attention and concentration, memory problems, impulsivity, headache, without objective findings on clinical imaging or examination. effects mTBI can persist become cumulative with repetitive injury, suggesting global alterations cortical networks. Using transparent polymer skulls, we...