A5101860648- Neurological Disease Mechanisms and Treatments
- Trace Elements in Health
- Cerebrovascular and Carotid Artery Diseases
- Angiogenesis and VEGF in Cancer
- Silicon and Solar Cell Technologies
- Barrier Structure and Function Studies
- Semiconductor materials and interfaces
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Vestibular and auditory disorders
- Thin-Film Transistor Technologies
- GDF15 and Related Biomarkers
- Metabolism and Genetic Disorders
- Moyamoya disease diagnosis and treatment
- Renin-Angiotensin System Studies
- S100 Proteins and Annexins
- Ophthalmology and Eye Disorders
- Sodium Intake and Health
- Infrared Thermography in Medicine
- Neuroinflammation and Neurodegeneration Mechanisms
- Wireless Sensor Networks and IoT
- Studies on Chitinases and Chitosanases
- Renal and Vascular Pathologies
- Magnesium in Health and Disease
- Mesenchymal stem cell research
Sun Yat-sen University
2015-2025
The First Affiliated Hospital, Sun Yat-sen University
2012-2025
Second Affiliated Hospital of Zhejiang University
2025
Brain (Germany)
2025
Jianghan University
2023-2024
Abstract Astrocytic dysfunction is a crucial factor for the pathogenesis of Alzheimer’s disease. Metabotropic glutamate receptor 5 (mGluR5) ubiquitously expressed in brain and key molecule that regulates synaptic transmission plasticity. It has been shown mGluR5 elevated astrocytes However, it remains elusive how astrocytic contributes to Here, we first quantified high expression level hippocampus disease brains demonstrated was positively correlated with progression both humans mice....
Excess salt (NaCl) intake is closely related to a variety of central nervous system (CNS) diseases characterized by increased cerebral microvascular permeability.However, the link between high diet (HSD) and breakdown tight junctions (TJs) remains unclear.In present study, we found that does not directly influence barrier endothelial cells, but it suppresses expression TJ proteins when cells are co-cultured with astrocytes.This effect independent blood pressure, depends on astrocyte...
Radiation-induced damage to the blood-brain barrier (BBB) is recognized pathological basis of radiation-induced brain injury (RBI), a side effect head and neck cancer treatments. There currently lack therapeutic approaches for RBI due ambiguity its underlying mechanisms. Therefore, it essential identify these mechanisms in order prevent or provide early interventions. One crucial factor contributing BBB disruption activation astrocytes oversecretion vascular endothelial growth (VEGF)....
We sought to characterize the cognitive function and neuropsychiatric symptoms in cerebral radionecrosis (CRN) patients who have received conformal radiation for nasopharyngeal carcinoma.A total of 40 treated with radiotherapy (RT) that developed CRN (RT + CRN), did not (RT-No-CRN), 36 newly diagnosed untreated carcinoma (No-RT) were recruited. The evaluated Montreal assessment (MoCA), mini-mental state examination (MMSE), activity daily living scale (ADL), inventory (NPI), Hamilton...
Abstract Compound/silicon heterojunction (SCH) solar cells have been widely studied because of the low parasitic absorption window layer, high short‐circuit current, and simple preparation process. So far, most reported SCH are small‐area devices. By depositing MoO x hole transport layer using hot‐wire oxidation–sublimation deposition technique employing a front‐contact back‐junction cell architecture, large‐area successfully fabricated on M6 (166 mm) n‐type silicon wafers. Indium cerium...
Although Ag‐coated Cu technology is considered to be an effective approach mitigate the metallization expenses associated with silicon heterojunction (SHJ) solar cells, there limited reporting on photovoltaic performance and reliability of devices employing Ag/Cu electrodes. Herein, industrial SHJ cells were successfully fabricated, yielding average efficiency 25.18% bifacial fingers, which caused a 0.13% decline in but saved 46% Ag consumption when compared traditional fingers. Performance...
Abstract Objective To investigate the cause of motor asymmetry in Wilson's disease ( WD ) patients using functional MRI . Methods Fifty with and 20 age‐matched healthy controls were enrolled. Neurological symptoms scored modified Young Scale. All study subjects underwent diffusion tensor imaging DTI ), susceptibility‐weighted SWI resting‐state (rs‐ fMRI brain. Six regions interest ROI chosen. Fiber volumes between s on , corrected phase CP values amplitude low‐frequency fluctuation ALFF...
Vascular damage plays an important role in the pathogenesis of radiation-induced brain injury (RBI). Endothelial progenitor cells (EPCs) are responsible for maintaining and repairing endothelial function, have become a promising method treatment cerebrovascular diseases. However, whether EPC transplantation protective RBI has not been fully elucidated. Therefore, present study investigated effects bone marrow-derived whole-brain irradiation (WBI) mouse model. Mice were divided into three...
The aim of this study was to evaluate the feasibility characterizing brain-mineral deposition in patients with Wilson disease (WD) using susceptibility-weighted imaging (SWI).The enrolled 30 WD and 20 age-matched healthy controls. Neurological symptoms were scored modified Young Scale. hepatic function indices, serum urinary copper content, iron content determined. All objects received magnetic resonance (MRI) SWI test brain. values corrected phase (CP) calculated on SWI. relationship...
YKL-40 is a novel inflammatory protein. Elevated serum levels of have been reported in patients with atherosclerosis and other cardiovascular diseases, but the circulating profile cerebrovascular disease has less investigated. This prospective observational study aimed to determine different subtypes severities disease. Eighty acute ischemic stroke, 30 hemorrhagic 15 transient attack (TIA) 18 age- gender-matched healthy control subjects were recruited. Blood was sampled. Serum measured by...
Purpose To assess whether relative cerebral blood volume (rCBV) can provide information to reliably evaluate the stages of late delayed radiation‐induced brain injury. Materials and Methods Forty patients diagnosed with injury were enrolled. The examined using a 1.5T magnetic resonance imaging (MRI) system equipped an 8‐channel head coil. An echo planar (EPI) sequence was used in perfusion‐weighted (PWI). location 1H‐MR spectroscopy scanning acquired by point‐resolved sequence. Lesions...
Abstract Background Multiple system atrophy (MSA) is a neurodegenerative disease that progresses rapidly and has poor prognosis. This study aimed to assess the value of video oculomotor evaluation (VOE) in differential diagnosis MSA Parkinson's (PD). Methods In total, 28 patients with MSA, 31 PD, 30 age‐ sex‐matched healthy controls (HC) were screened included this study. The consisted gaze‐holding test, smooth pursuit eye movement (SPEM), random saccade, optokinetic nystagmus (OKN). Results...
Abstract Background and Purpose Inflammatory reaction plays a critical role in the pathogenesis of late delayed radiation‐induced brain injury (RBI). Low vitamin D levels are closely associated with various immuno‐inflammatory diseases, but relationship RBI remains unknown. Here, we aimed to determine association serum clinical parameters patients nasopharyngeal carcinoma. Methods 25‐Hydroxyvitamin D3 cerebrospinal fluid were evaluated 21 compared 90 age‐, sex‐, season‐matched healthy...