A5012277695- Respiratory viral infections research
- Cytomegalovirus and herpesvirus research
- Blood donation and transfusion practices
- SARS-CoV-2 and COVID-19 Research
- Parvovirus B19 Infection Studies
- Bacterial Infections and Vaccines
- Herpesvirus Infections and Treatments
- COVID-19 Clinical Research Studies
- Influenza Virus Research Studies
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 detection and testing
- HIV/AIDS Research and Interventions
- Infectious Encephalopathies and Encephalitis
- Spinal Fractures and Fixation Techniques
- Viral Infections and Immunology Research
- Streptococcal Infections and Treatments
- Pneumonia and Respiratory Infections
- Vaccine Coverage and Hesitancy
- Neonatal and Maternal Infections
- Hepatitis B Virus Studies
- Hemoglobinopathies and Related Disorders
- Spine and Intervertebral Disc Pathology
- Bacterial Identification and Susceptibility Testing
- HIV, Drug Use, Sexual Risk
- Viral-associated cancers and disorders
Centre Hospitalier Universitaire Sainte-Justine
2016-2025
Université de Montréal
2016-2025
Héma-Québec
2021-2025
Université de Montpellier
2024
Hospital for Sick Children
2023
McGill University Health Centre
2023
Montreal Children's Hospital
2023
Polytechnique Montréal
2023
Nantes Université
2013-2022
McGill University
2020
OBJECTIVES: The pathogens that cause bacterial meningitis in infants and their antimicrobial susceptibilities may have changed this era of increasing resistance, use conjugated vaccines, maternal antibiotic prophylaxis for group B Streptococcus (GBS). objective was to determine the optimal empirical antibiotics early infancy. METHODS: This a cohort study <90 days age with at 7 pediatric tertiary care hospitals across Canada 2013 2014. RESULTS: There were 113 patients diagnosed proven...
Human metapneumovirus (HMPV), a common respiratory virus, can cause severe disease in pre- and post-hematopoietic cell transplantation (HCT) recipients. We conducted retrospective cohort analysis HCT patients with HMPV (n = 23) or syncytial virus detected bronchoalveolar lavage samples by reverse transcription PCR between 2006 2011 to determine characteristics factors associated outcome. Mortality rates at 100 days were 43% for both lower tract disease. Steroid therapy, oxygen requirement >2...
Abstract Background and Objectives Until recently, gay, bisexual other men who have sex with (MSM) were deferred from donating blood for 3–12 months since the last male‐to‐male sexual contact. This MSM deferral has been discontinued by several high‐income countries (HIC) that now perform gender‐neutral donor selection. Materials Methods An international symposium (held on 20‐04‐2023) gathered experts seven HICs to (1) discuss how this paradigm shift might affect mitigation strategies...
Antiviral resistance among influenza A viruses is associated with high morbidity and mortality in immunocompromised hosts. However, treatment strategies for drug-resistant are not established. triple-combination antiviral drug (TCAD) regimen consisting of amantadine (AMT), oseltamivir (OSL) ribavirin (RBV) demonstrated good efficacy an animal model.
This prospective, consecutive, multicentre observational registry aimed to confirm the safety and clinical performance of SpineJack system for treatment vertebral compression fractures (VCF) traumatic origin. We enrolled 103 patients (median age: 61.6 years) with 108 VCF due trauma, or associated osteoporosis. Primary outcome was back pain intensity (VAS). Secondary outcomes were Oswestry Disability Index (ODI), EuroQol-VAS, analgesic consumption. 48 hours after surgery, a median relative...
Congenital cytomegalovirus infection (cCMV) is the most common congenital infection, occurring in approximately 0.5% of live births. Most infected newborns are asymptomatic, but up to 20% develop sensorineural hearing loss or other permanent neurologic sequelae. The presentation with symptomatic cCMV highly variable, and usually not diagnosed absence a screening program. Newborn programs estimated be beneficial cost-effective, increasingly being implemented. Diagnosis requires direct...
Abstract Background The two Canadian blood suppliers, Blood Services and Héma‐Québec, removed the time‐based deferral for men who have sex with adopted criteria assessing sexual risk behaviors. We report impact of these changes on safety adequacy supply. Study Design Methods Since 2022, all donors are asked if (1) they had a new partner (2) more than one in last 3 months. Donors answering yes to either question anal months; yes, deferred followed HIV rates 18 months before 14 (Héma‐Québec)...
Leptin is a hormone that plays important roles in nutritional status and obesity. By means of immunocytochemistry, two populations leptin-secreting cells were found the lower half gastric mucosa. One consists numerous large located around pits, Chief epithelial cells, whereas second refers to much smaller strongly stained, few number, scattered between endocrine cells. double immunostaining, leptin pepsinogen colocalized positive only for leptin. Immunoelectron microscopy showed present...
Abstract Most oseltamivir-resistant pandemic (H1N1) 2009 viruses have been isolated from immunocompromised patients. To describe the clinical features, treatment, outcomes, and virologic data associated with infection virus H275Y mutation in patients, we retrospectively identified 49 hematology–oncology patients infected virus. Samples 33 of those were tested for genotype by allele-specific real-time PCR. Of 8 whom mutations was identified, 1 had severe pneumonia; 3 mild pneumonia prolonged...
Continuous monitoring blood culture systems (CMBCS) now allow for more rapid detection of microbial growth. We aimed to determine whether a 36-hour period was sufficient detect all cultures positive pathogenic bacteria in infants 0 90 days old undergoing septic workup the emergency department tertiary care pediatric center.We performed retrospective study collected these over 5-year time (from March 13, 2008 July 29, 2013). Bottles were incubated CMBCS. The positivity (TTP) calculated from...
OBJECTIVE To perform a post-outbreak prospective study of the Pseudomonas aeruginosa contamination at faucets (water, aerator and drain) by culture quantitative polymerase chain reaction (qPCR) to assess environmental factors influencing occurrence SETTING A 450-bed pediatric university hospital in Montreal, Canada METHODS Water, swab, drain swab samples were collected from analyzed qPCR for investigation. Water microbial physicochemical parameters measured, detailed characterization sink...
As the coronavirus disease 2019 (COVID-19) pandemic second wave is emerging, it of upmost importance to screen population immunity in order keep track infected individuals. Consequently, immunoassays for severe acute respiratory syndrome 2 (SARS-CoV-2) with high specificity and positive predictive values are needed obtain an accurate epidemiological picture. more data accumulate about immune responses kinetics neutralizing-antibody (nAb) production SARS-CoV-2-infected individuals, new...
The clinical presentation and management of human metapneumovirus (hMPV) infections in immunocompromised children is not well understood.We performed a retrospective evaluation pediatric patients with laboratory-confirmed hMPV underlying hematologic malignancy, solid tumors, organ transplant, rheumatologic disease, and/or receipt chronic immunosuppressants. Data were analyzed using t tests Fisher's exact tests.Overall, 55 (median age: 5 years; range: months-19 years) infection documented...
<h3>BACKGROUND:</h3> <i>Kingella kingae</i> has been increasingly identified in patients with osteoarticular infections. Our main objective was to evaluate the association between carriage of <i>K. oropharynx preschool children and <h3>METHODS:</h3> We conducted this prospective case–control study 2 tertiary care pediatric hospitals (Canada Switzerland) 2014 2016. Potential cases were aged 6 48 months a presumptive diagnosis infection according treating emergency physician. Confirmed those...