A5072625159- Syphilis Diagnosis and Treatment
- Reproductive tract infections research
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- HIV, Drug Use, Sexual Risk
- Toxoplasma gondii Research Studies
- HIV Research and Treatment
- Sex work and related issues
- SARS-CoV-2 and COVID-19 Research
- Streptococcal Infections and Treatments
- Parasitic Infections and Diagnostics
- Hepatitis C virus research
- Vector-Borne Animal Diseases
- Virology and Viral Diseases
- Immunodeficiency and Autoimmune Disorders
- Viral Infections and Vectors
- Powdery Mildew Fungal Diseases
- Female Genital Mutilation/Cutting Issues
- Animal Disease Management and Epidemiology
- Herpesvirus Infections and Treatments
- Zoonotic diseases and public health
- Poxvirus research and outbreaks
- Parasitic Diseases Research and Treatment
- Parasite Biology and Host Interactions
- Tattoo and Body Piercing Complications
Institut National de Santé Publique du Québec
2015-2024
Institut National de Santé Publique
2015-2022
Centre hospitalier de l'Université Laval
2012-2019
Centre Hospitalier de l’Université de Montréal
2019
Ste. Anne's Hospital
2011-2017
University of Alberta
2014
Montreal General Hospital
2001-2012
Université Laval
2012
McGill University
2012
Public Health Agency of Canada
2012
HighlightsAntibodies against SARS-CoV-2 Spike correlate with COVID-19 severityRBD-specific IgM and IgA decline more rapidly than IgGSARS-CoV-2 neutralizing antibodies are elicited within 2 weeks of infectionNeutralizing significantly after resolution the infectionSummarySARS-CoV-2 is responsible for coronavirus disease 2019 (COVID-19) pandemic, infecting millions people causing hundreds thousands deaths. The glycoproteins mediate viral entry main targets antibodies. Understanding antibody...
As a result of their intimate contact with the land and nutritional habits, Inuit Nunavik are considered to be at risk from zoonotic infections. To better understand factors for Toxoplasma gondii infection, serosurvey was conducted in Nunavik, Québec, September 2004. A representative sample adult population participated this cross-sectional study (n = 917). Antibodies (IgG) against T. were detected by immunoassay. Information on sociodemographic characteristics, traditional activities,...
ABSTRACT The diagnosis of neurosyphilis (NS) is a challenge, especially in HIV-infected patients, and the criteria for deciding when to perform lumbar puncture (LP) patients with syphilis are controversial. We retrospectively reviewed demographic, clinical, laboratory data from 122 cases documented early who underwent an LP rule out NS, we evaluated 3 laboratory-developed validated real-time PCR assays, Treponema pallidum particle agglutination (TPPA) assay, fluorescent treponemal antibody...
The SARS-CoV-2 virus is responsible for the current worldwide coronavirus disease 2019 (COVID-19) pandemic, infecting millions of people and causing hundreds thousands deaths. Spike glycoprotein mediates viral entry main target neutralizing antibodies. Understanding antibody response directed against crucial development vaccine, therapeutic public health interventions. Here we performed a cross-sectional study on 106 SARS-CoV-2-infected individuals to evaluate humoral responses Spike. vast...
In June 2000, bear meat infected with Trichinella nativa was consumed by 78 individuals in 2 northern Saskatchewan communities. Interviews and blood collections were performed on exposed at the onset of outbreak 7 weeks later. All treated mebendazole or albendazole, symptomatic patients received prednisone. Confirmed cases more likely to have dried meat, rather than boiled (P<.001). Seventy-four percent completed recommended therapy, 87% who followed up August 2000 reported complete...
As the coronavirus disease 2019 (COVID-19) pandemic second wave is emerging, it of upmost importance to screen population immunity in order keep track infected individuals. Consequently, immunoassays for severe acute respiratory syndrome 2 (SARS-CoV-2) with high specificity and positive predictive values are needed obtain an accurate epidemiological picture. more data accumulate about immune responses kinetics neutralizing-antibody (nAb) production SARS-CoV-2-infected individuals, new...
Repeated outbreaks of trichinellosis caused by the consumption Trichinella-infected walrus (Odobenus rosmarus) meat, which have sometimes led to serious morbidity, stimulated Inuit communities in Nunavik (northern Quebec), Canada, develop an innovative prevention program. The program involves preconsumption testing meat samples from harvested at a regional laboratory and rapid dissemination results such communities. Local health authorities Inukjuak conducted epidemiological investigation...
Summary In Nunavik, common practices and food habits such as consumption of raw meat untreated water place the Inuit at risk for contracting zoonotic diseases. The aim this study was to determine seroprevalence seven infections among permanent residents Nunavik. conducted in fall 2004 part Nunavik Health Survey. Blood samples from adults aged 18–74 years ( n = 917) were collected analysed presence antibodies against Trichinella spp., Toxocara canis, Echinococcus granulosus , Brucella...
Neurosyphilis refers to infection of the central nervous system by Treponema pallidum, which may occur at any stage. has been categorized in many ways including early and late, asymptomatic versus symptomatic infectious non-infectious. Late neurosyphilis primarily affects parenchyma, occurs beyond latent syphilis, years decades after initial infection. Associated clinical syndromes include general paresis, tabes dorsalis, vision loss, hearing loss psychiatric manifestations. Unique...
Syphilis, caused by the bacterium Treponema pallidum subsp. , is an infection recognized since antiquity. It was first reported at end of 15th century in Europe. Infections may be sexually transmitted as well spread from infected mother to her fetus or through blood transfusions. The laboratory diagnosis syphilis complex. Because this organism cannot cultured, serology used principal diagnostic method. Some issues related serological diagnoses are that antibodies take time appear after...
The Cree communities of James Bay might be at risk contracting zoonoses from their contacts with wildlife. Evidence exposure to seven zoonotic infections, namely Trichinella spp., Toxoplasma gondii, Toxocara canis, Echinococcus granulosus, Leptospira Coxiella burnetii, and Francisella tularensis, was sought in sera 267 residents Chisasibi (166) Waskaganish (101). Study participants responded questionnaires documenting socio-demographic characteristics hunting trapping activities....
The rapid confirmatory Bio-Rad Geenius HIV 1/2 assay was evaluated as an alternative to the HIV-1 Western blot (WB) assay. A total of 370 retrospective samples collected from 356 patients were tested. Sensitivity detect and HIV-2 infections 100% 97%, respectively, that WB 86% 39%, respectively. reduced number indeterminate results by 85% exhibited a differentiation capacity for 89%, Three 10 presenting with early infection (1 2 weeks before seroconversion WB) positive using Geenius. None...
The Cree communities of James Bay are at risk for contracting infectious diseases transmitted by wildlife. Data from serological testing a range zoonotic infections performed in the general population (six communities), or trappers and their spouses (one community), were abstracted four population‐based studies conducted territory (Quebec) between 2005 2009. Evidence exposure to Trichinella species, Toxoplasma gondii , Toxocara canis Echinococcus granulosus Leptospira Coxiella burnetii...
Recent analyses have shown an emerging positive association between sex work and human immunodeficiency virus (HIV) incidence among people who inject drugs (PWIDs) in the SurvUDI network.Participants had injected past 6 months were recruited across Province of Quebec city Ottawa, mainly harm reduction programs. They completed a questionnaire provided gingival exudate for HIV antibody testing. The associations with seroconversion tested Cox proportional hazard model using time-dependent...
Canada eliminated measles in 1998. We conducted a sero-epidemiology study to estimate population immunity the province of Ontario, and identify groups at higher risk outbreaks. used previously developed modified enzyme immunoassay test 1,199 residual sera from patients aged 1–39 years. re-tested negative equivocal using plaque reduction neutralization assay. interpreted our results context Ontario's immunization program vaccine coverage data. Of sera, 1035 (86.3%, 95% confidence interval...
Background Accurate and practical biologic tools to estimate HIV incidence is crucial better monitor the epidemic evaluate effectiveness of prevention treatment programs. Methods We evaluated two avidity assays measure recent infection: Sedia HIV-1 LAg-Avidity EIA (Sedia Biosciences, Portland) Centers for Disease Control Prevention (CDC)-modified Bio-Rad-Avidity assay (Bio-Rad Laboratories, Mississauga, ON). Longitudinal specimens (n = 473) obtained from 123 treatment-naive seroconverted...
The COVID-19 pandemic has led to the influx of immunoassays for detection antibodies towards severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into global market. Canadian Public Health Laboratory Network Serology Task Force undertook a nationwide evaluation twelve laboratory and 6 point-of-care based commercial serological assays SARS-CoV-2 antibodies. We determined that there was considerable variability in performance individual tests an orthogonal testing algorithm should be...
Background Intense transmission of syphilis has emerged in some Canadian Arctic communities despite screening and prevention efforts. The remoteness most limited diagnostic infrastructure yield long delays (≥14 days) between treatment cases. These hamper control efforts may contribute to sustained transmission. Syphilis rapid tests (RDTs) have been developed make more accessible inform clinical decision-making within the same encounter. RDTs successfully deployed several countries, but not...
This study was undertaken to search for the presence of immunoglobulin G (IgG)-binding proteins in Streptococcus suis, an important swine pathogen. Whole bacterial cells were incubated with human or pig IgG conjugated gold particles and examined by transmission electron microscopy. Cells some S. suis strains labelled as positive control strain, Staphylococcus aureus Cowan I. Binding five different species group D streptococci, reference representing 29 capsular types 12 type 2 then using...