A5000549201- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Graphene and Nanomaterials Applications
- Erythrocyte Function and Pathophysiology
- HIV Research and Treatment
- Bacteriophages and microbial interactions
- Bacterial biofilms and quorum sensing
- Electrospun Nanofibers in Biomedical Applications
- Extracellular vesicles in disease
- Nanoparticles: synthesis and applications
- SARS-CoV-2 and COVID-19 Research
- Platelet Disorders and Treatments
- Gold and Silver Nanoparticles Synthesis and Applications
- Inhalation and Respiratory Drug Delivery
- Antimicrobial Peptides and Activities
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- HIV/AIDS Research and Interventions
- Monoclonal and Polyclonal Antibodies Research
- Bacterial Infections and Vaccines
- Antimicrobial Resistance in Staphylococcus
- Lipid Membrane Structure and Behavior
- Vaccine Coverage and Hesitancy
Arcturus Therapeutics (United States)
2023-2024
University of California, San Diego
2012-2019
Moores Cancer Center
2013-2014
La Jolla Bioengineering Institute
2013
University of California, Berkeley
2013
City of Hope
2011
Oregon State University
2011
Beckman Research Institute
2011
Cell-derived nanoparticles have been garnering increased attention due to their ability mimic many of the natural properties displayed by source cells. This top-down engineering approach can be applied toward development novel therapeutic strategies owing unique interactions enabled through retention complex antigenic information. Herein, we report on biological functionalization polymeric with a layer membrane coating derived from cancer The resulting core-shell nanostructures, which carry...
Cell‐membrane‐coated nanoparticles have recently been studied extensively for their biological compatibility, retention of cellular properties, and adaptability to a variety therapeutic imaging applications. This class nanoparticles, which has fabricated with cell membrane coatings, including those derived from red blood cells (RBCs), platelets, white cells, cancer bacteria, exhibit properties that are characteristic the source cell. In this study, new type coating is created by fusing...
Significance Clinical evidence has indicated that the systemic spread of endotoxins from septic infection plays a crucial role in pathogenesis Gram-negative bacterial sepsis. However, currently there are no effective ways to manage diverse released by different genus, species, and strain. Herein, we demonstrate therapeutic potential macrophage-like nanoparticle for sepsis control through powerful two-step neutralization process: endotoxin first step followed cytokine sequestration second...
Anticancer vaccines train the body's own immune system to recognize and eliminate malignant cells based on differential antigen expression. While conceptually attractive, clinical efficacy is lacking given several key challenges stemming from similarities between cancerous healthy tissue. Ideally, an effective vaccine formulation would deliver multiple tumor antigens in a fashion that potently stimulates endogenous responses against those antigens. Here, it reported fabrication of...
Synthetic nanoparticles coated with cellular membranes have been increasingly explored to harness natural cell functions toward the development of novel therapeutic strategies. Herein, we report on a unique bacterial membrane-coated nanoparticle system as new and exciting antibacterial vaccine. Using Escherichia coli model pathogen, collect outer membrane vesicles (OMVs) successfully coat them onto small gold (AuNPs) diameter 30 nm. The resulting AuNPs (BM-AuNPs) show markedly enhanced...
Gold nanoparticles are enclosed in cellular membranes derived from natural red blood cells (RBCs) by a top-down approach. The gold exhibit complete membrane surface layer and biological characteristics of the source cells. combination inorganic with is compelling way to develop biomimetic nanostructures for future applications, such as those requiring evasion immune system.
The unique structural features and stealth properties of a recently developed red blood cell membrane-cloaked nanoparticle (RBC-NP) platform raise curiosity over the interfacial interactions between natural cellular membranes polymeric substrates. Herein, several aspects RBC-NPs are examined, including completeness membrane coverage, sidedness upon coating, effects particles' surface charge curvature on cloaking process. study shows that RBC completely cover negatively charged nanoparticles...
We investigate the 'marker-of-self' functionalization of nanoparticles through coating natural RBC membranes. The membrane translocation approach is shown to be highly efficient and bestows with correctly oriented functional immunomodulatory proteins such as CD47 at equivalent density RBCs.
RBC membrane-cloaked polymeric nanoparticles represent an emerging nanocarrier platform with extended circulation in vivo. A lipid-insertion method is employed to functionalize these without the need for direct chemical conjugation. Insertion of both folate and nucleolin-targeting aptamer AS1411 shows receptor-specific targeting against model cancer cell lines.
Significance The selective depletion of disease-causing antibodies using nanoparticles offers a new model in the management type II immune hypersensitivity reactions. demonstration pathophysiologically inspired nanoengineering serves as valuable prototype for additional therapeutic improvements with goal minimizing therapy-related adverse effects. Through use cell membrane-cloaked nanoparticles, nanoscale decoys strong affinity to pathological can be administered disrupt disease processes...
Abstract Intratumoral immunotherapy is an emerging modality for the treatment of solid tumors. Toll-like receptor (TLR) agonists have shown promise eliciting immune responses, but systemic administration often results in development adverse side effects. Herein, we investigate whether localized delivery TLR agonist, resiquimod (R848), via platelet membrane-coated nanoparticles (PNP-R848) elicits antitumor responses. The membrane coating provides a means enhancing interactions with tumor...
The therapeutic potential of nanoparticle-based drug carriers depends largely on their ability to evade the host immune system while delivering cargo safely site action. Of particular interest are simple strategies for functionalization nanoparticle surfaces that both inherently safe and can also bestow immunoevasive properties, allowing extended blood circulation times. Here, we evaluated a recently reported cell membrane-coated platform as delivery vehicle treatment murine model lymphoma....
Combination of waning immunity and lower effectiveness against new SARS-CoV-2 variants approved COVID-19 vaccines necessitates vaccines. We evaluated two doses, 28 days apart, ARCT-154, a self-amplifying mRNA vaccine, compared with saline placebo in an integrated phase 1/2/3a/3b controlled, observer-blind trial Vietnamese adults (ClinicalTrial.gov identifier: NCT05012943). Primary safety reactogenicity outcomes were unsolicited adverse events (AE) after each dose, solicited local systemic AE...
Long-circulating polymeric nanotherapeutics have garnered increasing interest in research and the clinic owing to their ability improve solubility pharmacokinetics of therapeutic cargoes. Modulation carrier properties promises more effective drug localization at disease sites can lead enhanced safety efficacy. In present review, we highlight current development clinic. light importance stealth nanoparticles, also review advances functionalization strategies examine performance different...
Organophosphate poisoning is highly lethal as organophosphates, which are commonly found in insecticides and nerve agents, cause irreversible phosphorylation inactivation of acetylcholinesterase (AChE), leading to neuromuscular disorders via accumulation acetylcholine the body. Direct interception organophosphates systemic circulation thus provides a desirable strategy treatment condition. Inspired by presence AChE on red blood cell (RBC) membranes, we explored biomimetic nanoparticle...
Using microRNA array analyses of in vitro HIV-1-infected CD4+ cells, we find that several host microRNAs are significantly up- or downregulated around the time HIV-1 infection peaks vitro. While microRNA-223 levels were enriched CD4+CD8− PBMCs, microRNA-29a/b, microRNA-155 and microRNA-21 reduced. Based on potential for binding sites a conserved sequence Nef-3′-LTR, potentially could affect gene expression. Among those microRNAs, microRNA-29 family has seed complementarity 3′-UTR, but...
A hybrid nanomaterial integrating unique toxin-absorbing nanosponges with hydrogel is developed for local antivirulence therapy against methicillin-resistant Staphylococcus aureus (MRSA) infection. The composition optimized to retain toxin after administration while not compromising transport into the gel neutralization. Mice treated nanosponge–hydrogel show markedly reduced MRSA skin lesion development.