A5079271587- SARS-CoV-2 and COVID-19 Research
- HIV, Drug Use, Sexual Risk
- HIV/AIDS Research and Interventions
- COVID-19 epidemiological studies
- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Sex work and related issues
- Influenza Virus Research Studies
- Bacterial Infections and Vaccines
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Vaccine Coverage and Hesitancy
- Immunotherapy and Immune Responses
- HIV Research and Treatment
- Animal Virus Infections Studies
- COVID-19 Pandemic Impacts
- Mosquito-borne diseases and control
- Adolescent Sexual and Reproductive Health
- Fungal Infections and Studies
- HIV/AIDS drug development and treatment
- Reproductive tract infections research
- Viral gastroenteritis research and epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Antifungal resistance and susceptibility
- Census and Population Estimation
Institut Pasteur in Ho Chi Minh City
2016-2025
Institut Pasteur
2025
Murdoch Children's Research Institute
2024
Duke-NUS Medical School
2024
Menzies School of Health Research
2024
ARC Centre of Excellence for Enabling Eco-Efficient Beneficiation of Minerals
2023
The University of Queensland
2020-2023
HCMC Hospital of Dermato Venereology
2023
The University of Texas at Austin
2022
Hanoi Medical University
2017
Combination of waning immunity and lower effectiveness against new SARS-CoV-2 variants approved COVID-19 vaccines necessitates vaccines. We evaluated two doses, 28 days apart, ARCT-154, a self-amplifying mRNA vaccine, compared with saline placebo in an integrated phase 1/2/3a/3b controlled, observer-blind trial Vietnamese adults (ClinicalTrial.gov identifier: NCT05012943). Primary safety reactogenicity outcomes were unsolicited adverse events (AE) after each dose, solicited local systemic AE...
Nonpharmaceutical interventions (NPIs) implemented to contain SARS-CoV-2 have decreased invasive pneumococcal disease. Previous studies proposed the decline is due reduced transmission or suppression of respiratory viruses, but mechanism remains unclear. We undertook a secondary analysis data collected from clinical trial evaluate impact NPIs on carriage and density, drivers disease, during COVID-19 pandemic in Ho Chi Minh City, Vietnam. Nasopharyngeal samples children aged 24 months were...
Vietnam has emerged as one of the world's leading success stories in responding to COVID-19. After a prolonged period little no transmission, there was an outbreak unknown source July, 2020, Da Nang region, but quickly suppressed. We aimed use epidemiological, behavioural, demographic, and policy data from COVID-19 calibrate agent-based model transmission for Vietnam, estimate risk future outbreaks associated with reopening international borders country.
Background Preterm infants are highly vulnerable to infectious disease. While many factors likely contribute this enhanced susceptibility, the immature nature of preterm immune system is postulated as one key factor. Methods In our study, we used high-dimensional flow cytometry and cytokine assays characterise profiles in 25 (range: 30.4-34.1 weeks gestational age) term infant 37-40 cord blood samples. Results We found that exhibit reduced frequencies monocytes, CD56 bright NK cells, CD8+...
Nanocovax is a recombinant severe acute respiratory syndrome coronavirus 2 subunit vaccine composed of full-length prefusion stabilized SARS-CoV-2 spike glycoproteins (S-2P) and aluminium hydroxide adjuvant.We conducted dose-escalation, open label trial (phase 1) randomized, double-blind, placebo-controlled 2) to evaluate the safety immunogenicity (in 25 mcg, 50 75 mcg doses, adjuvanted (0·5 mg/dose) in 2-dose regime, 28 days apart (ClinicalTrials.gov number, NCT04683484). In phase 1, 60...
Interest in reduced-dose pneumococcal conjugate vaccine (PCV) schedules is growing, but data on their ability to provide direct and indirect protection are scarce. We evaluated 1 + (at 2 months 12 months) 0 of PCV10 or PCV13 a predominately unvaccinated population.
In Brief Background The prevalence of HIV and sexually transmitted infections among men who have sex with (MSM) has increased substantially in Vietnam. This study aimed to estimate the HIV, syphilis, urethral gonorrhoea, chlamydia, determined correlates infection MSM An Giang, Methods A group 381 were recruited a community-based cross-sectional survey between August December 2009. Face-to-face interviews conducted for collecting data on sociodemographics, behaviors, access prevention...
Public health concerns due to ongoing emergence of SARS-CoV-2 variants necessitates further development improved COVID-19 vaccines. One major innovation are self-amplifying mRNA vaccines such as ARCT-154 (Arcturus Therapeutics Inc.) which induces superior immunogenicity compared with conventional in terms magnitude, breadth and persistence neutralizing antibodies. In a pivotal placebo-controlled trial Vietnam combining phase 1, 2 3 cohorts, over 17,000 adults received at least one dose...
Streptococcus pneumoniae is a major cause of morbidity and mortality in children. This study investigates the clinical features, cerebrospinal fluid (CSF) findings, serotype distribution, antibiotic resistance patterns Vietnamese children aged 1-59 months with pneumococcal meningitis (PM). retrospective (2012-2023) was conducted at two tertiary pediatric hospitals Ho Chi Minh City. CSF samples from probable bacterial (PBM) cases were analyzed using biochemistry, culture, real-time polymerase...
Cervical cancer is the most frequently diagnosed malignancy among women in southern Vietnam where its incidence one of highest observed worldwide. HPV DNA infection was measured a cross-sectional sample 282 female sex workers (FSW) Soc Trang province Vietnam. detected 85% FSW and prevalence did not vary by age. Thirty-five genotypes were detected; 52 common type. Half HPV-positive infected with oncogenic types 37% multiple genotypes. The lower more formal education (adj. ratio = 0.63, 95% CI...
<h3>Objectives</h3> This study aims to investigate the levels and correlates of unprotected anal intercourse (UAI), drug alcohol use, HIV testing among Vietnamese men who have sex with (MSM). <h3>Methods</h3> A total 381 MSM were recruited in a community-based cross-sectional survey two towns (Long Xuyen Chau Doc) An Giang province 2009 by using two-stage cluster sampling. Face-to-face interviews conducted elicit respondents’ characteristics. Regression analysis was used determine key...
In January 2020, we identified two severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients in a familial cluster with one person coming from Wuhan, China. The complete genome sequences of SARS-CoV-2 strains isolated these were identical and 99.98% similar to Wuhan. This is genetically suggestive human-to-human transmission indicates Wuhan as the most plausible origin early outbreak Vietnam. younger patient had mild upper illness brief viral shedding, whereas elderly...
To determine the prevalence of selected STIs and correlates chlamydia (CT) gonorrhea (GC) infection among (FSWs) in Soc Trang province, Vietnam.Four hundred six FSWs province participated a cross-sectional study between May August, 2003. The subjects were interviewed to obtain information about socio-demographic behavioral characteristics gynecologic STI history, using standardized interview. They underwent physical examination during which cervical swabs collected for GC CT testing by...
We report on an outbreak of nongroupable Neisseria meningitidis-associated urethritis, primarily among men who have sex with in southern Vietnam. Nearly 50% N. meningitidis isolates were resistant to ciprofloxacin. This emerging pathogen should be considered the differential diagnosis and management urethritis.
Risk behaviors among female sex workers (FSW) are considerable drivers of HIV infections in Vietnam, especially transmission between high-risk and low-risk groups. We assessed prevalence its correlates FSWs, the use preventive services this community Mekong Delta region, southern Vietnam.A cross-sectional survey 1,999 FSWs was carried out five provinces including Ben Tre, Hau Giang, Kien Tien Vinh Long June, 2006 2007. interviewed participants face-to-face order to elicit information about...
This retrospective hospital-based surveillance aimed to assess the epidemiology, causative pathogens trend, and serotypes distribution of pneumococcal meningitis among children aged under 5 years with bacterial in Southern Vietnam after introduction pentavalent vaccine Expanded Program on Immunization (EPI).From 2012 2021, cerebrospinal fluid samples were collected from suspected at Children's Hospitals 1 2 Ho Chi Minh City. Probable (PBM) cases identified using biochemistry cytology....
The use of pneumococcal conjugate vaccine (PCV) schedules with fewer doses are being considered to reduce costs and improve access, particularly in low- middle-income countries. While several studies have assessed their immunogenicity, there limited data on potential for long-term immune protection, as by serotype-specific memory B cell (Bmem) responses. This current study reports secondary outcome that aims compare Bmem responses following reduced-dose (0 + 1 1) PCV10 PCV13 Vietnamese...
Background After more than a decade of steadily declining notifications, the number reported cholera cases has recently increased in Vietnam. We conducted matched case-control study to investigate transmission during an outbreak Ben Tre, southern Vietnam, and explore associated risk factors. Methodology/Principal findings Sixty 71 diarrheal patients confirmed be infected with by culture diagnosed between May 9 August 3, 2010 Tre were consecutively recruited as case-patients. Case-patients...