Abstract Synthetic biology has advanced the design of standardized transcription control devices that programme cellular behaviour. By coupling synthetic signalling cascade- and factor-based gene switches with reverse differential sensitivity to licensed food additive vanillic acid, we designed a lineage-control network combining acid-triggered mutually exclusive expression for factors Ngn3 (neurogenin 3; OFF-ON-OFF) Pdx1 (pancreatic duodenal homeobox 1; ON-OFF-ON) concomitant induction MafA...

Highlights•A closed-loop gene network with bacterial sense-and-destroy actuation•Direct diagnosis of implant-associated infections through blood biomarkers•Early prevention MRSA infection, as well biofilm formation, in vivo•Curing acute an alternative to antibiotic therapySummaryMany community- and hospital-acquired are caused by antibiotic-resistant pathogens. Methicillin-resistant Staphylococcus aureus (MRSA) predisposes humans invasive that difficult eradicate. We designed a programming...

The liver performs a panoply of complex activities coordinating metabolic, immunologic and detoxification processes. Despite the liver's robustness unique self-regeneration capacity, viral infection, autoimmune disorders, fatty disease, alcohol abuse drug-induced hepatotoxicity contribute to increasing prevalence failure. Liver injuries impair clearance bile acids from hepatic portal vein which leads their spill over into peripheral circulation where they activate G-protein-coupled acid...

Abstract Plants generate a plethora of secondary compounds (toxins) that potently influence the breadth breeding niches animals, including Drosophila . Capsaicin is an alkaloid irritant from hot chili peppers, and can act as deterrent to affect animal behaviors, such egg laying choice. However, mechanism underlying this ovipositional avoidance remains unknown. Here, we report females exhibit robust aversion capsaicin. First, found were robustly repelled eggs on capsaicin-containing sites....

This case highlights the diagnostic challenges of atrial flutter with concealed activity on surface electrocardiograms, emphasizing necessity invasive electrophysiological study to avoid unnecessary pacemaker implantation in patients structural heart disease-a scenario rarely documented current literature. A 60-year-old ​Chinese woman rheumatic mitral stenosis and prior maze procedure presented fatigue bradycardia (heart rate, 47 beats per minute). Surface electrocardiograms (including...

Abstract Background Since animals frequently encounter a variety of harmful fungi in nature, their ability to develop sophisticated anti-fungal strategies allows them flourish across the globe. Extensive studies have highlighted significant involvement indigenous microbial communities human health. However, daunting diversity mammalian microbiota and host genetic complexity are major obstacles our understanding these intricate links between components, immune genotype, disease phenotype. In...

Abstract Metazoans harbor a wealth of symbionts that are ever‐changing the environment by taking up resources and/or excreting metabolites. One such common environmental modification is change in pH. Conventional wisdom holds facilitate survival and production their hosts wild, but this notion lacks empirical evidence. Here, we report symbiotic bacteria genus Enterococcus attenuate oviposition avoidance alkaline environments Drosophila . We studied effects alkalinity on preference for first...

Abstract Background Animals frequently encounter a variety of harmful fungi in the wild, but their ability to develop sophisticated anti-fungal strategies allows them flourish across globe. Extensive studies have highlighted significant involvement indigenous microbial communities host health, daunting complexity microflora has hampered our understanding intricate relationships among them. In this work, we sought bacterium-fungus-Drosophila model that offered systematically evaluate effects...

Abstract Background Since animals frequently encounter a variety of harmful fungi in nature, their ability to develop sophisticated anti-fungal strategies allows them flourish across the globe. Extensive studies have highlighted significant involvement indigenous microbial communities human health. However, daunting diversity mammalian microbiota and host genetic complexity are major obstacles our understanding these intricate links between components, immune genotype, disease phenotype. In...

Abstract Background Since animals frequently encounter a variety of harmful fungi in nature, their ability to develop sophisticated anti-fungal strategies allows them flourish across the globe. Extensive studies have highlighted significant involvement indigenous microbial communities human health. However, daunting diversity mammalian microbiota and host genetic complexity are major obstacles our understanding these intricate links between components, immune genotype, disease phenotype. In...

Abstract Background Since animals frequently encounter a variety of harmful fungi in nature, their ability to develop sophisticated anti-fungal strategies allows them flourish across the globe. Extensive studies have highlighted significant involvement indigenous microbial communities human health. However, daunting diversity mammalian microbiota and host genetic complexity are major obstacles our understanding these intricate links between components, immune genotype, disease phenotype. In...

Abstract Background Since animals frequently encounter a variety of harmful fungi in nature, their ability to develop sophisticated anti-fungal strategies allows them flourish across the globe. Extensive studies have highlighted significant involvement indigenous microbial communities human health. However, daunting diversity mammalian microbiota and host genetic complexity are major obstacles our understanding these intricate links between components, immune genotype, disease phenotype. In...