A5009064461- Inhalation and Respiratory Drug Delivery
- Combustion and Detonation Processes
- Aerosol Filtration and Electrostatic Precipitation
- Airway Management and Intubation Techniques
- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Pharmacological Effects and Assays
- Granular flow and fluidized beds
- Microencapsulation and Drying Processes
Orexo (Sweden)
2023
Uppsala University
2018-2022
The aim of this study was to investigate how the carrier morphology affects expression blend states in adhesive mixtures as a function surface coverage ratio (SCR) and identify where transitions between different occur. Adhesive five lactose carriers with varying contents fines, corresponding blends SCR ranging from 0 6, were produced by low-shear mixing. powder mechanics characterized bulk density, compressibility permeability. appearance studied scanning electron microscopy, light...
The objectives of this investigation were to study the evolution in blend state adhesive mixtures containing active pharmaceutical ingredients (APIs) salbutamol, budesonide and AZD5423 relationship between dispersibility mixtures, as assessed by fine particle fraction (FPF). A series varied fines concentration prepared for each API using same type carrier. Based on visual examination powder mechanics, states identified summarized maps API. was studied a Fast Screening Impactor (FSI) equipped...
In this study, the effect of pressure drop (ΔP) on in vitro dispersion a series carrier-based adhesive mixtures different fines-to-carrier proportions, corresponding to four blend states state model, i.e. S1 S3, was investigated. Four binary and one ternary mixture consisting lactose carrier budesonide fines were prepared. The assessed using next generation impactor (NGI) at ΔP 0.5, 2 4 kPa. For mixture, where located surface cavities carrier, fine particle fraction (FPF) increased nearly...
Most pulmonary drugs are immediate-release formulations with short duration of action. Controlled release systems provide the ability to deliver at a controlled rate, which helps maintain drug concentrations within therapeutic window for longer period time. This study aimed produce microparticles (MPs) hyaluronic acid hydrogel (HAGA) loaded salbutamol sulphate (SS) in lung. The drug-loaded MPs were prepared via spray drying and underwent extensive characterization, revealed that SS was...