A5013500867- Drug Solubulity and Delivery Systems
- Granular flow and fluidized beds
- Powder Metallurgy Techniques and Materials
- Inhalation and Respiratory Drug Delivery
- Rheology and Fluid Dynamics Studies
- Advanced Drug Delivery Systems
- Crystallization and Solubility Studies
- Material Dynamics and Properties
- Surfactants and Colloidal Systems
- Protein purification and stability
- Microencapsulation and Drying Processes
- Mineral Processing and Grinding
- Aerosol Filtration and Electrostatic Precipitation
- Adhesion, Friction, and Surface Interactions
- Particle Dynamics in Fluid Flows
- Advancements in Transdermal Drug Delivery
- Hydrogels: synthesis, properties, applications
- Combustion and Detonation Processes
- Fluid Dynamics Simulations and Interactions
- Injection Molding Process and Properties
- Geotechnical and Geomechanical Engineering
- Fluid Dynamics and Heat Transfer
- Lipid Membrane Structure and Behavior
- Ferroelectric and Piezoelectric Materials
- Tunneling and Rock Mechanics
Uppsala University
2015-2024
Chalmers University of Technology
2004
Hydrogels warrant attention as a potential material for use in sustained pulmonary drug delivery due to their swelling and mucoadhesive features. Herein, hyaluronic acid (HA) is considered promising its therapeutic potential, the effect on lung inflammation, possible utility an excipient or carrier. In this study, feasibility of using HA hydrogels (without model drug) engineer inhalation powders controlled was assessed. A combination chemical crosslinking spray-drying proposed novel...
We apply a theory to the constrained swelling of gel particles, explicitly accounting for propagation elastic forces through particle. This approach, together with conventional thermodynamics swelling, allows modelling equilibrium state gels properties that are spatially inhomogeneous. In our case we consider both discrete inhomogeneity in form assigning different water solubilities core and shell domains particle, continuous allowing density chemical cross-links vary gradually network. The...
A novel method to calculate single-particle fabric tensors and related geometric characteristics (contact, free particle area, volume contact centroid) of assemblies spherical particles has been developed. standard detection stage is used identify overlapping particles. The shape each region obtained as the intersection a circle, in absence any impingement, convex polygon, determined by half-plane based on directed lines from planes. An underlying power diagram subdivide area between...
Proteolytic degradation and release of microgel-bound peptides was investigated for trypsin, poly(acrylic acid-co-acrylamide) microgels (70–90 μm in diameter), oppositely charged polylysine, using a method combination confocal microscopy micromanipulator-assisted light microscopy. Results show that trypsin-induced polylysine increased with increasing trypsin concentration, decreasing microgel charge density peptide molecular weight. While the offered good protection against enzymatic at high...
Herein, electrostatic swelling transitions of poly(ethyl acrylate-co-methacrylic acid) microgels covalently bound to silica surfaces are investigated. Confined at a solid surface, microgel is anisotropically hindered and the structure flattened an extent dictated by pH composition. Microgel deformation under applied load also shown depend on charge density, with highest observed intermediate densities. Two modes were observed, one elastic viscoelastic, related polymer strand displacement...
The aim of this study was to investigate how the carrier morphology affects expression blend states in adhesive mixtures as a function surface coverage ratio (SCR) and identify where transitions between different occur. Adhesive five lactose carriers with varying contents fines, corresponding blends SCR ranging from 0 6, were produced by low-shear mixing. powder mechanics characterized bulk density, compressibility permeability. appearance studied scanning electron microscopy, light...