Nobuhisa Matsuhashi
A5061553422- Colorectal Cancer Surgical Treatments
- Computational Drug Discovery Methods
- Diet and metabolism studies
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Colorectal and Anal Carcinomas
- Gastrointestinal Tumor Research and Treatment
- Esophageal and GI Pathology
- Sarcoma Diagnosis and Treatment
- Nutrition, Genetics, and Disease
- Diverticular Disease and Complications
- Anorectal Disease Treatments and Outcomes
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Screening and Detection
- Neurofibromatosis and Schwannoma Cases
- Genetic factors in colorectal cancer
- Surgical Simulation and Training
- Neuroendocrine Tumor Research Advances
- Cancer Diagnosis and Treatment
- Anatomy and Medical Technology
- Cancer Genomics and Diagnostics
- Cancer Treatment and Pharmacology
- Nutrition and Health in Aging
- Hepatocellular Carcinoma Treatment and Prognosis
Gifu University
2016-2025
Gifu University Hospital
2005-2024
Gifu Prefectural General Medical Center
2010-2018
Oji General Hospital
1999
Posttreatment detection of ctDNA is strongly predictive recurrence. Most minimal/molecular residual disease assays require prior tissue testing to guide analysis, resulting in lengthy time initial results and unevaluable patients.
In recent years, laparoscopic surgery has been widely used for rectal cancer. surgery, a double-stapling technique (DST) anastomosis using stapling device is considered relatively difficult procedure. Postoperative anastomotic leakage (AL) major complication related to patients' quality of life and prognosis.This study was retrospective, single-institution 101 cancer patients who underwent low anterior resection (LAR) with DST (excluding simultaneous other organs construction protective...
The prognosis of esophageal cancer patients is still unsatisfactory. Although a docetaxel, cisplatin, and 5-Fu (DCF) regimen has been reported, it often difficult to accomplish because severe toxicity. Therefore, we developed new biweekly DCF (Bi-DCF) previously reported the recommended dose in phase I dose-escalation study. We then performed II study Bi-DCF for advanced squamous cell carcinoma (SCC). Patients with clinical stage II/III were eligible. received 2 courses chemotherapy:...
The right top pulmonary vein (RTPV) is a rare anatomical variant that arises independently of the superior lobe. It drains behind main bronchus or intermedius and into left atrium another vein. This anomaly poses challenges during subcarinal lymph node dissection in thoracic surgery, such as esophagectomy, owing to risk vascular injury. RTPV mainly located intermediate bronchus; however, reports focusing on these sites are lacking. Herein, we present case esophageal cancer with an was...
Although the efficacy of trifluridine/tipiracil (FTD/TPI) plus bevacizumab (BEV) against metastatic colorectal cancer (mCRC) has been demonstrated, little is known about its effectiveness upon disease stratification by RAS mutations. In this phase II study, we investigated and safety profiles FTD/TPI in mCRC according to mutation status.Eligible patients were refractory or intolerant all standard therapies other than regorafenib. Patients received 4-week cycles treatment with (35 mg/m2,...
Complex surgery during initial cancer treatment can limit surgical options when planning management of a secondary malignancy. Subtotal esophagectomy and pancreatoduodenectomy are the most invasive difficult procedures in gastroenterological surgery. Surgical cases which subtotal was performed after with pancreaticogastrostomy extremely rare challenging due to resulting complicated anatomical changes. A 60-year-old man history conversion for advanced pancreatic head diagnosed as having...
257 Background: Disappearing liver metastases (DLMs) diagnosed on post-chemotherapy (Cx) computed tomography (CT) is a favorable prognostic factor in patients (pts) with colorectal (CRLM). However, the optimal treatment of DLMs - whether they should be resected or left behind controversial. This prospective, multi-centred, international study examining added value MRI (DWI, T1/T2 and contrast-enhanced) to that CT alone accurate assessment viability DLMs. Methods: Pts initially unresectable...
5-Fluorouracil (5-FU) plays a major role in the treatment of gastric cancer (GC), and overcoming resistance to this drug remains critical challenge. This study aimed identify genes associated with 5-FU GC. Gene expression levels were analyzed 5-FU-resistant MKN-45/F2R cells compared parental MKN-45 strain before after (24 72 h). Among consistently over-expressed genes, those high further investigated for their roles patterns GC tissues. NPC1L1, protein hypothesized influence resistance, did...
Schwannomas arise from Schwann cells of the peripheral nerve sheath. are usually benign, and most them located in head, neck, or distal extremities. The retroperitoneal region is an unusual location for schwannomas. seen adults very rare pediatric population. A 6-year-old boy was referred to our institution with a right abdominal mass. His main complaint intermittent myoclonus his lower limb. Abdominal computed tomography (CT) magnetic resonance imaging scans revealed round-shaped solid mass...
PURPOSE The utility of capturing heterogeneity by circulating tumor DNA (ctDNA) genotyping combined with tissue analysis or applying it in a sequential manner remains uncertain. METHODS We assessed the clinical value ctDNA using data from 2,187 patients advanced solid tumors enrolled SCRUM-Japan MONSTAR-SCREEN-1, nationwide cancer genome screening project, which examined longitudinally collected blood samples and (UMIN 000036749). RESULTS Among 667 both baseline results, 51 (7.6%) had...
Abstract Although the gut microbiome is associated with cancer development and progression, little known about effects of landscape efficacy immune checkpoint inhibitors (ICIs) across types. We investigated association between microbiome, clinical features, ICIs types in a large nationwide screening project for solid tumors. Among 2,180 patients advanced tumors enrolled SCRUM-Japan MONSTAR-SCREEN October 2019 September 2021, chemotherapy-naïve cohort (n=817), t high prevalence oral bacteria...
<p>Association of ICI efficacy with concomitant medication use.</p>
<p>Patient characteristics in cohort 2</p>
<p>Association of ICI efficacy with ASV based on treatment.</p>
<p>Patient characteristics in cohort 1</p>
<p>Patient characteristics of four groups based on PPI use and the abundance oral bacteria in feces</p>
<p>The ALDEx2 analysis of flora according to PFS ICI treatment.</p>
<p>ICI efficacy between two categories of the proportion oral bacteria in feces.</p>
<p>Relationship between ICI efficacy and bacterial flora/concomitant medication use. <b>A,</b> Kaplan–Meier plots of the PFS patients treated with ICIs in high ASV group low group. The cutoff was 206.0 (median). <b>B,</b> Forest plot analysis depicting association clinical features ICIs. Dots error bars represent point estimates HR 95% CIs. Antibio, antibiotics; MSI-H, MSI high; MSS, microsatellite stable; TMB-H, TMB TMB-L, low; Probio, probiotics....
<p>Association of ICI efficacy with ASV based on treatment.</p>
<p>Validation with publicly data about oral bacteria and the efficacy of ICIs</p>