A5014474209- Esophageal Cancer Research and Treatment
- Marine Ecology and Invasive Species
- Developmental Biology and Gene Regulation
- Gastric Cancer Management and Outcomes
- Bacterial Identification and Susceptibility Testing
- Prostate Cancer Treatment and Research
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Antibiotic Resistance in Bacteria
- Monoclonal and Polyclonal Antibodies Research
- SARS-CoV-2 detection and testing
- Marine Invertebrate Physiology and Ecology
- Cancer Immunotherapy and Biomarkers
- Chronic Kidney Disease and Diabetes
- Animal Virus Infections Studies
- Breast Cancer Treatment Studies
- Dialysis and Renal Disease Management
- Enterobacteriaceae and Cronobacter Research
- Vascular Malformations and Hemangiomas
- RNA Research and Splicing
- Lung Cancer Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Cardiovascular Health and Disease Prevention
- Erythrocyte Function and Pathophysiology
- Cancer Diagnosis and Treatment
Aichi Medical University
2023-2025
Aichi Medical University Hospital
2012-2024
Osaka University
2005-2023
Juntendo University
2023
Juntendo University Urayasu Hospital
2020
Yokohama City University
2010-2019
Yokohama City University Medical Center
2010-2019
Yokohama Rosai Hospital
2019
Tokyo Medical University Hospital
2019
Kanagawa Cancer Center
2018-2019
In most human breast cancer cell lines, there is a direct correlation between their in vivo invasive phenotypes and vitro invasion activities. Here, we found that ADP-ribosylation factor 6 (Arf6) localized at the invadopodia of cultured cells MDA-MB-231, its suppression by small-interfering RNA duplex effectively blocks activities cells, such as formation, matrix degradation Matrigel transmigration but not cell-adhesion activity. We also GTP hydrolysis-defective mutant Arf6(Q67L) GTP-binding...
Ninety one Japanese patients with systemic lupus erythematosus (SLE) were studied to determine the clinical significance of antibodies ribosomal P protein (anti-P). Anti-P was detected by western blotting in 38 91 (42%). Clinical symptoms SLE compared between and without anti-P. The occurrence psychosis significantly higher anti-P than those (9/38 v 1/53). No significant association found other SLE. These data strongly support suggestion proposed previous workers that is a marker...
Invasive potentials of carcinomas greatly contribute to their metastasis, which is a major threat in most cancers. We have recently shown that Arf6 plays pivotal role breast cancer invasive activities and identified AMAP1 as an effector GTP-Arf6 invasion. Expression correlates well with phenotypes primary tumors the human breast. also functions by forming trimeric protein complex cortactin paxillin. In this complex, binds src homology 3 (SH3) domain via its proline-rich peptide,...
SUMMARY Ctenophores and cnidarians are two metazoan groups that evolved at least 600 Ma, predating the Cambrian explosion. Although both commonly categorized as diploblastic animals without derivatives of mesodermal germ layer, ctenophores possess definitive contractile “muscle” cells. T‐box family transcription factors an evolutionarily ancient gene family, arising in common ancestor metazoans, have been divided into eight five distinct subfamilies, many which involved specification well...
ABSTRACT The major mesodermal tissues of ascidian larvae are muscle, notochord and mesenchyme. They derived from the marginal zone surrounding endoderm area in vegetal hemisphere. Muscle fate is specified by localized ooplasmic determinants, whereas specification mesenchyme requires inducing signals at 32-cell stage. In present study, we demonstrated that all precursors were able to induce formation cells presumptive blastomeres, respectively, indicating type tissue induced depends on...
The prognosis of esophageal cancer patients is still unsatisfactory. Although a docetaxel, cisplatin, and 5-Fu (DCF) regimen has been reported, it often difficult to accomplish because severe toxicity. Therefore, we developed new biweekly DCF (Bi-DCF) previously reported the recommended dose in phase I dose-escalation study. We then performed II study Bi-DCF for advanced squamous cell carcinoma (SCC). Patients with clinical stage II/III were eligible. received 2 courses chemotherapy:...
Abstract The three‐dimensional structure of bacterial sphingomyelinase (SMase) was predicted using a protein fold recognition method; the search library known structures showed that SMase sequence is highly compatible with mammalian DNase I structure, which suggested adopts similar to I. amino acid alignment based on prediction revealed that, despite lack overall similarity (less than 10% identity), those residues are involved in hydrolysis phosphodiester bond, including two histidine (His...
Brevibacteria are obligate aerobic gram-positive rods that associated with milk products and also found on human skin. Brevibacterium has been reported as a rare cause of catheter related blood steam infection mainly in immunocompromised hosts such malignancies or AIDS patients. A 94-year old woman, which had past history diabetes mellitus chronic heart failure, presented high fever decreased oral intake appetite loss was admitted to our institute. physical examination at the time...
Although varicella zoster virus (VZV) infection is generally considered self-limiting and shows a favorable outcome, herpes (HZ) can cause several complications such as neurological pain or meningitis, which lowers the patients' quality of life. HZ rarely manifests VZV pneumonia, resulting in poor prognosis with high mortality rate 10-30 % if requiring mechanical ventilation. Here, we present rare successfully managed case pneumonia. A 90-year-old man medical history angina pectoris,...
The 110-kDa intracellular phosphoprotein (110K) described previously by this laboratory as a common IgM autoantigen in SLE and certain other systemic autoimmune disorders viral infections is identified nucleolin the present investigation. Using rabbit antiserum to rat probe, autoantibody-reactive 110K co-migrated with human lymphocyte one- two-dimensional immunoblots. Rabbit anti-nucleolin also specifically depleted autoreactive from detergent lysates of cells. Because shares amino acid...
Background/Aim: This study aimed to assess whether low-molecular-weight heparin (LMWH) is effective and safe in preventing postoperative venous thromboembolism (VTE) patients undergoing esophageal cancer surgery. Patients Methods: In this single-institution, prospective, randomized trial, 73 with esophagectomy were randomly divided into the enoxaparin group (E group) intermittent pneumatic compression (I group). The primary endpoint was efficacy of enoxaparin, secondary endpoints evidence...
To evaluate a novel therapy for triple-negative breast cancer (TNBC), the biological responses to vitamin K3 (VK3) should be considered with understanding of features cancer. In human cell lines, effects VK3 on growth inhibition and cellular signaling pathway were determined by MTT assay western blotting. in vivo study, subcutaneous tumor model was created, injected into tumors, size measured. The IC50 cells calculated 11.3-25.1 µM. induced phosphorylation whole tyrosine epidermal factor...