A5033735204- Renal Transplantation Outcomes and Treatments
- T-cell and B-cell Immunology
- Cytomegalovirus and herpesvirus research
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Dialysis and Renal Disease Management
- Chronic Lymphocytic Leukemia Research
- Renal Diseases and Glomerulopathies
- Pancreatic function and diabetes
- Parvovirus B19 Infection Studies
- SARS-CoV-2 and COVID-19 Research
- Polyomavirus and related diseases
- Organ Transplantation Techniques and Outcomes
- Neurosurgical Procedures and Complications
- Mechanical Circulatory Support Devices
- Cardiovascular Syncope and Autonomic Disorders
- CAR-T cell therapy research
- Diabetes and associated disorders
Institut de Transplantation Urologie en Nephrologie
2019-2023
Nantes Université
2016-2023
Center for Research in Transplantation and Translational Immunology
2019-2023
Centre d'Investigation Clinique de Nantes
2022-2023
Inserm
2016-2023
Centre Hospitalier Universitaire de Nantes
2019-2020
Renal operationally tolerant patients (TOL) display a defect in B cell differentiation, with deficiency plasma cells. Recently described, T follicular helper (Tfh) cells play critical role differentiation. We analyzed blood Tfh subsets TOL and transplanted stable graft function under immunosuppression (STA). observed reduced proportion of activated highly functional TOL, without affecting absolute numbers. Functionally, from displayed modified gene expression profile, failed to produce...
Granzyme B-expressing B cells have been shown to be an important regulatory cell subset in humans. However, it is unclear which subpopulations of express GZMB under normal conditions and protocols effectively induce ex vivo expansion GZMB+ cells. We found that the peripheral blood individuals, plasmablasts were major subpopulation expressed GZMB. when using vitro plasmablast differentiation protocol, we obtained only 2% Nevertheless, mixture containing IL-21, anti-BCR, CpG...
The human immune system contains cells with either effector/memory or regulatory functions. Besides the well-established CD4+CD25hiCD127lo T (Tregs), we and others have shown that B can also functions since their frequency number are increased in kidney graft tolerance cell depletion as induction therapy may lead to acute rejection. On other hand, CD28-CD8+ represent a subpopulation potent In current study, tested hypothesis allograft rejection be linked an imbalance of cells. Based on large...
Donor-specific anti-HLA antibodies (DSAs) are a major risk factor associated with renal allograft outcomes. As trigger of B cell antibody production, T follicular helper cells (Tfhs) promote DSA appearance. Herein, we evaluated whether circulating Tfhs (cTfhs) the genesis antibody-mediated rejection. We measured cTfh levels on day transplantation and one year after in blood from prospective cohort 237 patients without during first post-transplantation. Total cTfhs were characterized as...
Kidney transplant recipients have been supposed vulnerable to severe Covid-19 infection, due their comorbidities and immunosuppressive therapies. Mild-term complications of are currently unknown, especially in this population. Herein, we report two cases BKV replication after non-severe SARS-CoV-2 infection. The first case was a 59-year-old man, transplanted 3 months ago, with recent history slight viremia (3.3 log10 DNA copies/ml). Despite strong reduction maintenance immunosuppression...