A5087574187- Diabetes Treatment and Management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiovascular Function and Risk Factors
- Metabolism, Diabetes, and Cancer
- Diabetes Management and Research
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipoproteins and Cardiovascular Health
- Pancreatic function and diabetes
- Blood Pressure and Hypertension Studies
- Cancer, Lipids, and Metabolism
- Diet and metabolism studies
- Healthcare during COVID-19 Pandemic
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac and Coronary Surgery Techniques
- Liver Disease Diagnosis and Treatment
- Retinal Imaging and Analysis
- Nuclear Receptors and Signaling
- Retinal Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Eicosanoids and Hypertension Pharmacology
- Acute Myocardial Infarction Research
- Agricultural and Food Sciences
Universidade Estadual de Campinas (UNICAMP)
2012-2021
Instituto Dante Pazzanese de Cardiologia
2015
Universidade de Brasília
2009-2015
Universidade de São Paulo
2015
Abstract Background The glucose-lowering independent effect of sodium glucose cotransporter-2 inhibitors (SGLT2i) on arterial wall function has not yet been clarified. This study aims to assess whether SGLT2i treatment can attenuate endothelial dysfunction related type 2 diabetes mellitus (T2D) compared with equivalent therapy. Methods In a prospective, open-label, single-center, randomized clinical trial, 98 patients T2DM and carotid intima-media thickness above the 75th percentile were 1:1...
The decrease in insulin sensitivity (IS) during myocardial infarction (MI) is recognized as a possible contributor to poor patient outcomes. Despite its potential relevance, standardized and convenient IS assessment tool has yet be established for said clinical scenarios. This study aimed validate the accuracy of surrogate indexes determining acute MI patients by comparison with gold standard reference method measuring IS, euglycemic-hyperinsulinemic clamp (EHC). We performed EHCs 31...
Abstract We compared the effect of dapagliflozin versus glibenclamide on ratio lean-to total mass in patients with type 2 diabetes mellitus, carotid subclinical atherosclerosis, HbA1c 7.0–9.0% and 40–70 years-old. Ninety-eight (61% male; mean age 57 ± 7 years) were randomized into 10 mg/day or 5 top metformin. Body composition was measured by Dual Energy X-Ray at randomization after 12 weeks treatment. Glycemic control equivalent both groups. Dapagliflozin decreased body (−2741 g [95% CI:...
Endothelial dysfunction (ED) is a hallmark in type 2 diabetes mellitus (T2DM) that favor both atherogenesis and ischemia reperfusion injury (IRI). Sodium-glucose-2 co-transporter inhibitors (SGLT2i) may hypothetically improve microvascular macrovascular functions via broad spectrum of mechanisms, being superior to traditional antidiabetic therapy such as sulfonylurea, even subjects under equivalent glycemic control. Hence, the present clinical trial was designed compare effect these two...
The combinations of adipokines and body mass parameters to estimate carotid atherosclerotic disease have not been completely delineated.To test the well-established, easily accessible indices circulating biomarkers identify increased intima-media thickness (cIMT) in a primary prevention setting.In cross-sectional analysis 339 asymptomatic individuals with no history cardiovascular events, inflammatory insulin sensitivity as well adipokine levels were measured combined evaluate best marker...
The favorable effects of insulin during myocardial infarction (MI) remain unclear due to the divergence between mechanistic studies and clinical trials exogenous administration. rs7903146 polymorphism transcription factor 7-like 2 (TCF7L2) gene is associated with attenuated secretion.In non-diabetic patients ST-elevation MI (STEMI), using such a model genetically determined down-regulation endogenous secretion we investigated change in plasma insulin, C-peptide, interleukin-2 (IL-2),...
Hyperglycemia during myocardial infarction (MI) has a strong and direct association with mortality. In stable patients experimental models, statins favor the elevation of glycaemia. The present study investigated whether short-course treatment MI can influence glucose homeostasis thus clinical outcome. this prospective study, euglycemic hyperinsulinemic clamp (EHC) was performed at second (D2) sixth (D6) day after in randomized to simvastatin (S)10 or 80 mg/day hospitalization (n = 27)....
AbstractEvaluation of: Buchwald H, Rudser KD, Williams SE, Michalek VN, Vagasky J, Connett JE: Overall mortality, incremental life expectancy and cause of death in the Program on Surgical Control Hyperlipidemia. Annal. Surg. 241, 1034–1040 (2010). The Hyperlipidemia (POSCH) trial was designed aiming to evaluate effect cholesterol reduction by ileal bypass mortality patients with previous myocardial infarction. surgical procedure increases fecal loss bile acids, promoting hepatocellular...
O Diabetes Mellitus (DM) é uma doença crônica metabólica que caracterizada pela hiperglicemia.Esta estimula as vias bioquímicas responsáveis pelas alterações fisiopatológicas do diabetes, dentre elas a via dos produtos finais de glicação avançada (AGEs).Alguns estudos clínicos já ilustraram relação entre