A5000564678- Food Allergy and Anaphylaxis Research
- Drug-Induced Adverse Reactions
- Allergic Rhinitis and Sensitization
- Contact Dermatitis and Allergies
- Cultural and Sociopolitical Studies
- Asthma and respiratory diseases
- Immunodeficiency and Autoimmune Disorders
- Antibiotics Pharmacokinetics and Efficacy
- Turkish Literature and Culture
- Linguistics and Cultural Studies
- Immune Cell Function and Interaction
- Infant Health and Development
- Neonatal skin health care
- Epilepsy research and treatment
- Cytomegalovirus and herpesvirus research
- Dermatology and Skin Diseases
- Pharmacological Effects and Toxicity Studies
- Pharmaceutical studies and practices
- Occupational exposure and asthma
- Urticaria and Related Conditions
- Pediatric health and respiratory diseases
- Menstrual Health and Disorders
- Thermal Regulation in Medicine
- Oral and gingival health research
- Hypothalamic control of reproductive hormones
Istanbul University
2016-2025
Ministry of Health
2020
Sağlık Bilimleri Üniversitesi
2020
Bülent Ecevit University
2016
Abstract Background Lockdown was imposed for children 75 days in Turkey to limit the spread of COVID‐19. During this period, have stay indoors, which might probably increase their exposures indoor allergens and pollutants. Besides, reduced respiratory tract infections outdoor pollutants be favorable outcomes lockdown period. We evaluated effects on house dust mite (HDM)–sensitized with allergies. Methods Three‐month clinical medication data 165 mild‐moderate asthmatic or without allergic...
Aim The aim of the study was define normal values tympanic and axillary body temperature in healthy children. Methods This observational cross-sectional performed children aged 0 to 17 years who visited ambulatory general pediatric Istanbul Medical Faculty. Results Of 1364 children, 651 (47.7%) were girls 713 boys, mean (SD, range) age 72.5 (53.6, 1–204) months. (SD) 36.04°C (0.46°C; minimum, 35.0°C; maximum, 37.6°C). 95th 99th percentiles 36.8°C 37.0°C, respectively. 36.91°C 35.15°C;...
Abstract The group of patients with DNA‐repair‐defects increases susceptibility to infections due impaired repertoire diversity. In this context, we aimed investigate the TCRvβ‐repertoire by flow cytometric analysis and its correlation clinical entities in a IEI DNA repair defects. Peripheral lymphocyte subset analyses were performed analysis. aim was explore changing TCR‐Vβ‐repertoire that can predict some investigating using flow‐cytometric‐analysis‐based TCR‐Vβ interaction TCR‐repertoire...
Introduction: Beta-lactam (BL) antibiotics are the most often involved drugs in allergic reactions. Mild cutaneous reactions such as maculopapular exanthema or urticaria common presenting complaints of BL allergy pediatric population. However, it can be challenging to distinguish BL-induced from due infections other reasons. In this study, we aimed determine clinical characteristics and potential risk factors true children with suspected mild BLs. Methods: We evaluated who were admitted our...
Diaper dermatitis is one of the most common skin diseases in early childhood. The prevalence diaper varies between 7% and 35% depending on population age groups. There may be some differences among pediatricians about treatment approaches to this condition.The purpose study evaluate management strategies for dermatitis.The questionnaire-based cross-sectional was conducted September December 2021. questionnaire which contained 21 items aimed investigate treatment, follow-up prevention...
<b><i>Background:</i></b> Urticaria can be the only sign of a food allergy or seen together with other signs and symptoms allergy. <b><i>Objective:</i></b> To determine demographic, etiologic, clinical features food-induced acute urticaria in childhood. <b><i>Methods:</i></b> Patients suspected were included this prospective cross-sectional multicenter study. <b><i>Results:</i></b> Two hundred...
Clarithromycin hypersensitivity is reported as the most common cause of non-β-lactam antibiotic allergy in children. frequently prescribed cases suspected β-lactam hypersensitivity. Oral provocation tests stand gold standard to confirm drug diagnostic value skin variable. We analyzed frequency true clarithromycin ratio and its relationship with among children evaluated tests.The study included 160 referred Clinical history workups including or/and oral were retrieved from medical...
Yıldız EP, Hızlı Z, Bektaş G, Ulak-Özkan M, Tatlı B, Aydınlı N, Çalışkan Özmen M. Efficacy of rufinamide in childhood refractory epilepsy. Turk J Pediatr 2018; 60: 238-243. Rufinamide has been used as a new antiepileptic drug the treatment drug-resistant epilepsy, recent years. The objective this study was to evaluate reliability and its impact on seizure frequency patients diagnosed with where seizures could not be controlled `classical` drugs. We retrospectively reviewed data epileptic who...
Abstract Background Paracetamol, a non‐steroidal anti‐inflammatory drug, is commonly being used for fever and pain relief worldwide. The aim of this study was to evaluate children with suspected history paracetamol hypersensitivity. Methods Sixty patients who were referred our clinic in between January 2015 December 2018 hypersensitivity included. Reactions classified according the European Network Drug Allergy (ENDA)/Global Asthma classification Academy Clinical Immunology (EAACI)/ENDA...
Introduction: Ibuprofen is the most common culprit drug causing nonsteroidal anti-inflammatory (NSAID) hypersensitivity in children. We aimed to evaluate frequency, clinical characteristics, and risk factors of confirmed ibuprofen allergy children presenting with a history suspected immediate type ibuprofen-induced reactions. Methods: evaluated 50 (35 M, 15 F) median age 7 years, who were referred our clinic hypersensitivity. Patients subjected diagnostic work up including provocation tests...
Background: Several factors that increase the risk of severe food-induced anaphylaxis have been identified. Objective: We aimed to determine demographic, etiologic, and clinical features in early childhood also any other associated with anaphylaxis. Methods: carried out a medical chart review cases from 16 pediatric allergy immunology centers Turkey. Results: The data 227 patients 266 episodes were included study. median (interquartile range) age first episode was 9 months (6-18 months); 160...
The authors declare no conflicts of interest.
<b><i>Introduction:</i></b> Skin tests are one of the most widely used diagnostic tools for suspected drug allergies in children. Studies on systemic reactions occurring during skin testing with allergens have mostly been conducted pediatric and adult patient groups together. However, data adverse including allergic after children scarce. It is aimed to determine test allergy. <b><i>Methods:</i></b> Patients who underwent a due suspicion...
ABSTRACT Background Indoor allergen exposure and senitization is expected to increase significantly during the COVID‐19 pandemic. The aim of this study was assess impact altered on sensitivity patterns in children with asthma. Methods Demographic data, clinical characteristics, laboratory findings asthmatic aged 5 years younger were assessed May 2019 2020, 1 year after start lockdown measures. Those compared age‐ sex‐matched peers before Group I included who underwent skin testing within 12...
Allergen-specific immunotherapy, a unique inducer of tolerance, may result in T cell exhaution.
Food protein–induced enterocolitis syndrome (FPIES) is a non-immunoglobulin E (IgE)- mediated food allergy. However, the exact pathophysiology of FPIES not clearly understood, cell mechanisms are considered to be responsible. classified in two forms: acute and chronic. There no diagnostic laboratory tests for but methods can used other diseases differential diagnosis. The diagnosis based on clinical responses elimination suspected diets with resolution symptoms, oral challenges reappearance...
Amaç: Bu çalışmada amacımız okul öncesi astımlı çocuklarda yatmadan önceki son beslenme saati, uykuda beslenmeleri, gece yatma sabah kalkma saati ve sosyal çevresi ile ilgili faktörlerin üst solunum yolu semptomları astım kontrolü üzerine etkilerini araştırmaktadır. Gereç Yöntem: Çalışma, çocuklar benzer cinsiyet, yaş dağılımına sahip sağlıklı yapıldı. Bulgular: Çalışma gurubuna 103'ü (%47,5) astım, 114'ü (%52,5) olmak üzere 217 çocuk alındı. Gece önce 2 saat içinde sıklığı %47,6 iken %82,5...
Abstract Inborn errors of immunity include multiple genetic abnormalities affecting different components the innate and adaptive immune systems. More than 450 genes have been described so far including DNA repair defects which may result in predisposition to infections, but also malignancies, neurologic growth retardation. The group patients with methylation exhibit impaired immunity, increases susceptibility infections due repertoire diversity. In this context, we aimed investigate TCRvβ...